Is dental agenesis associated with craniofacial morphology pattern? A systematic review and meta-analysis

Rodrigues, Amanda Silva; Antunes, Leonardo Santos; Pinheiro, Liz Helena Moraes; Guimarães, Ludmila Silva; Calansans-Maia, José De Albuquerque; Küchler, Érika Calvano

doi:10.1093/ejo/cjz087

Cited by 7 publications

(10 citation statements)

References 45 publications

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“…A recent systematic review and meta-analysis summarized the evidence from conventional cephalometric studies and rated it as moderate to low. Moderate evidence supports the conclusion that individuals with tooth agenesis present a smaller SNA angle, but no solid conclusion could be drawn for any other outcome [16]. Since differences in craniofacial shape due to genetic linkages are likely to be subtle, a solid methodology is required for their detection.…”

Section: Introductionmentioning

confidence: 94%

Number of Teeth Is Related to Craniofacial Morphology in Humans

Oeschger

Kanavakis

Cocos

et al. 2022

Biology

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One of the most common dental anomalies in humans is the congenital absence of teeth, referred to as tooth agenesis. The association of tooth agenesis to craniofacial morphology has been previously investigated but remains unclear. We investigated this association by applying geometric morphometric methods in a large sample of modern humans. In line with previous studies, we report here that a reduced teeth number is linked to a less convex profile, as well as to a shorter face. The effects were similar for males and females; they increased as the severity of the tooth agenesis increased and remained unaltered by the inclusion of third molars and of allometry in the analysis. Furthermore, in cases with tooth agenesis only in the maxilla, there was no detectable effect in mandibular shape, whereas maxillary shape was affected independently of the location of missing teeth. The robustness of the present sample along with the shape analysis and the statistical approach applied, allowed for thorough testing of various contributing factors regarding the presence but also the magnitude of effects. The present findings suggest a relationship between number of teeth and overall craniofacial development and have evolutionary implications.

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Section: Introductionmentioning

confidence: 94%

Number of Teeth Is Related to Craniofacial Morphology in Humans

Oeschger

Kanavakis

Cocos

et al. 2022

Biology

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“…77 In addition, tooth agenesis may affect the oral arch length, jaw position and craniofacial morphological features. 78,79 Therefore, imaging is necessary for early diagnosis, prompt intervention 80 and multidisciplinary treatment to maintain the aesthetic and functional features of teeth.…”

Section: Clinical Feature and Treatment Strategies Of Supernumerary T...mentioning

confidence: 99%

Tooth number abnormality: from bench to bedside

Zhang

Gong

et al. 2023

Int J Oral Sci

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Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and supernumerary teeth. Tooth development is regulated by numerous developmental signals, such as the well-known Wnt, BMP, FGF, Shh and Eda pathways, which mediate the ongoing complex interactions between epithelium and mesenchyme. Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number; however, the underlying mechanisms remain elusive. In this review, we summarized the major process of tooth development, the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality. In addition, potential treatment approaches for tooth number abnormality based on developmental biology are also discussed. This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application.

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“…Additionally, 14 semi-landmarks were placed approximately equidistantly along the buccal contour of the maxilla and the contour of the palate (lm. [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The landmark configurations were scaled based on a measured scale bar, and oriented along the central axis of the alveolar ridge by projecting the landmarks of each configuration onto the two principal components of landmarks 1-5.…”

Section: Measurementsmentioning

confidence: 99%

“…While these studies clearly document an influence of tooth extraction or agenesis on maxillary form, the influence of maxillary size and shape on dental agenesis is less obvious. Various studies indicate that dental agenesis may not be purely genetically determined [15][16][17] because it is also associated with craniofacial morphology [18][19][20][21]. As tooth development proceeds concomitantly with alveolar growth, alveolar dimensions may influence odontogenesis [20,22]: a too small or inappropriately shaped alveolar process may inhibit normal formation or development of the tooth bud, leading to agenesis of a tooth in this anatomical region.…”

Section: Introductionmentioning

confidence: 99%

Maxillary lateral incisor agenesis is associated with maxillary form: a geometric morphometric analysis

et al. 2022

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Background and objective Agenesis of the maxillary lateral incisor occurs in up to 4% of all individuals and requires multidisciplinary treatment. Its developmental origins, however, are not fully understood. Earlier studies documented genetic factors contributing to agenesis but also an association with craniofacial morphology. In this study, we assessed the association between maxillary morphology and lateral incisor agenesis by a geometric morphometric approach to disentangle the roles of developmental plasticity and genetic factors. Materials and methods We quantified the maxillary alveolar ridge by 19 two-dimensional landmarks on cross-sectional images of 101 computed tomography scans. We compared the shape and size of the alveolar ridge across patients with unilateral or bilateral agenesis of maxillary lateral incisors and patients with extracted or in situ incisors. Results The maxillary alveolar ridge was clearly narrower in patients with agenesis or an extracted incisor compared to the control group, whereas the contralateral side of the unilateral agenesis had an intermediate width. Despite massive individual variation, the ventral curvature of the alveolar ridge was, on average, more pronounced in the bilateral agenesis group compared to unilateral agenesis and tooth extraction. Conclusions This suggests that pleiotropic genetic and epigenetic factors influence both tooth development and cranial growth, but an inappropriately sized or shaped alveolar process may also inhibit normal formation or development of the tooth bud, thus leading to dental agenesis. Clinical relevance Our results indicate that bilateral agenesis of the lateral incisor tends to be associated with a higher need of bone augmentation prior to implant placement than unilateral agenesis.

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Is dental agenesis associated with craniofacial morphology pattern? A systematic review and meta-analysis

Cited by 7 publications

References 45 publications

Number of Teeth Is Related to Craniofacial Morphology in Humans

Number of Teeth Is Related to Craniofacial Morphology in Humans

Tooth number abnormality: from bench to bedside

Maxillary lateral incisor agenesis is associated with maxillary form: a geometric morphometric analysis

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