Is Dexmedetomidine the Key for Reducing Acute Kidney Injury After Cardiac Surgery?

It’s All in the Details: Dexmedetomidine and Acute Kidney Injury After Cardiac Surgery

“…We thank Drs Kashani and Grocott for their interest in the Peng et al study 1 and our accompanying editorial. 2 We agree that the Peng et al study used strong methodology and statistical approach by application of meta-analysis with trial sequential analysis, particularly when considering previous systemic reviews asking a similar question. Therefore, our conclusions were not based on the use of trial sequential analysis but rather were 2-fold.…”

Optimal Interpretation of Trial Sequential Analysis in Understanding the Effect of Dexmedetomidine on Acute Kidney Injury After Cardiac Surgery

“…None. WE READ with interest the accompanying editorial by Wieruszewski et al 1 that added perspective to the findings by Peng et al 2 in their systemic review and meta-analysis with trial sequential analysis (TSA) of the role of dexmedetomidine (DEX) in the prevention of cardiac surgeryÀassociated acute kidney injury (CS-AKI). Although Wieruszewski et al pointed out many of the accompanying study's strengths, their interpretation of its TSA seemed somewhat counterintuitive.…”

Should Invasive Lines Be Placed in the Preoperative Procedure Room for Patients Undergoing Cardiac Surgery to Save Operating Room Time and Expense?

“…None. WE READ with interest the accompanying editorial by Wieruszewski et al 1 that added perspective to the findings by Peng et al 2 in their systemic review and meta-analysis with trial sequential analysis (TSA) of the role of dexmedetomidine (DEX) in the prevention of cardiac surgeryÀassociated acute kidney injury (CS-AKI). Although Wieruszewski et al pointed out many of the accompanying study's strengths, their interpretation of its TSA seemed somewhat counterintuitive.…”

“…In the United States, each minute of operating room time costs $36 to $94. 1 Throughout the world, the operating room is an expensive resource in the hospital. With increasing healthcare costs, there is an increasing drive to minimize operating room turnover time, especially when insurance companies are shifting toward bundled payments 2 ; therefore, it is prudent to have a thorough understanding of the pros and cons of the time and place of inserting invasive central lines.…”