Is donor-recipient sex associated with transfusion-related outcomes in critically ill patients?

Wood, Henry; Morton, Suzy

doi:10.1182/bloodadvances.2022008432

Cited by 3 publications

(3 citation statements)

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“…We also observed previously described differences between female and male donors in PZP levels, which is in line with several previous publications that PZP plasma levels are a proxy for sex 15,22,23 . This may be important in the context of sex‐related factors in blood product transfusions 24–26 . In this study, we also show that circulating plasma protein levels correlate with other blood count parameters (e.g., WBC and LBP).…”

Section: Discussionsupporting

confidence: 92%

“…15,22,23 This may be important in the context of sex-related factors in blood product transfusions. [24][25][26] In this study, we also show that circulating plasma protein levels correlate with other blood count parameters (e.g., WBC and LBP). Furthermore, we observed individual plasma protein signatures which are related to the immunological status, including donor-specific immunoglobulin D levels (Figure 2B).…”

Section: Discussionsupporting

confidence: 72%

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Mass spectrometry‐based analysis on the impact of whole blood donation on the global plasma proteome

et al. 2023

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Background: Biomonitoring may provide important insights into the impact of a whole blood donation for individual blood donors. Study Design and Methods: Here, we used unbiased mass spectrometry (MS)-based proteomics to assess longitudinal changes in the global plasma proteome, after a single blood donation for new and regular donors. Subsequently, we compared plasma proteomes of 76 male and female whole blood donors, that were grouped based on their ferritin and hemoglobin (Hb) levels. Results: The longitudinal analysis showed limited changes in the plasma proteomes of new and regular donors after a whole blood donation during a 180-day follow-up period, apart from a significant short-term decrease in fibronectin. No differences were observed in the plasma proteomes of donors with high versus low Hb and/or ferritin levels. Plasma proteins with the highest variation between and within donors included pregnancy zone protein, which was associated with sex, Alfa 1-antitrypsin which was associated with the allelic variation, and Immunoglobulin D. Coexpression analysis revealed clustering of proteins that are associated with platelet, red cell, and neutrophil signatures as well as with the complement system and immune responses, including a prominent correlating cluster of immunoglobulin M (IgM), immunoglobulin J chain (JCHAIN), and CD5 antigen-like (CD5L). Discussion: Overall, our proteomic approach shows that whole blood donation has a limited impact on the plasma proteins measured. Our findings suggest that plasma profiling can be successfully employed to consistently detect proteins and protein complexes that reflect the functionality and integrity of

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 72%

Mass spectrometry‐based analysis on the impact of whole blood donation on the global plasma proteome

et al. 2023

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“…Wood and Morton 1 express their opinion that the interpretation of the data in our article is misleading and should not be used to guide patient care. They argue that analyses of much larger databases have not found an association between donor sex and mortality and that the much smaller cohort in our study is therefore not of any further value.…”

mentioning

confidence: 96%