Is drug-resistant Salmonella typhi an emerging threat?

Kulkarni, Ketan; Singh, Meenu; Kumar, Rakesh

doi:10.1136/bcr.04.2009.1783

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ceftriaxone resistance was first reported in Bangladesh in 1999 [17] . There are sporadic reports from India of S. [2,18]. But recent studies from India report 100% sensitivity to Ceftriaxone [7,19,20] .…”

Section: Discussionmentioning

confidence: 99%

Study on recent trends in antibiogram of enteric fever pathogens in a tertiary care centre in South India

Kumar¹

2018

jmscr

View full text Add to dashboard Cite

Enteric fever is a systemic infection caused by Salmonella Typhi (S.Typhi), Salmonella Paratyphi A (S.Paratyphi A), Salmonella Paratyphi B and Salmonella Paratyphi C. It is endemic in India and is a major public health problem in the country. Treatment with Ciprofloxacin which was considered the drug of choice for multi drug resistant Salmonellae, is now showing high rates of failure clinically. A total of 33 isolates obtained from blood and bone marrow were tested for antimicrobial susceptibility by Kirby Bauer disc diffusion method. The minimum inhibitory concentrations of Ciprofloxacin & Ceftriaxone were determined by broth dilution method. Majority of the patients were young adults falling in the age group 16-35 years (57.7%).Only 2 isolates of S.Typhi were resistant to all three first line drugs (Ampicillin, Cotrimoxazole and Chloramphenicol) and classified as multi drug resistant S.Typhi (MDRST). One strain of S.Paratyphi A was resistant to Ampicillin. 90.9% of isolates were susceptible to Azithromycin. None of the isolates showed full susceptibility to Ciprofloxacin. 7 isolates showed intermediate susceptibility with an MIC of 0.5µg/mL. The MIC of Ceftriaxone showed an upward trend though still within the susceptible limits. 69.7% of the 33 isolates had an MIC of 0.06 µg/mL and 30.3% of isolates had an MIC of 0.12µg/mL. There is reemergence of susceptibility to the first line drugs. Presence of fluoroquinolone resistance and the rise in MIC of Ceftriaxone is a concern. Antibiotic stewardship has to be implemented urgently.

show abstract

Section: Discussionmentioning

confidence: 99%

Study on recent trends in antibiogram of enteric fever pathogens in a tertiary care centre in South India

Kumar¹

2018

jmscr

View full text Add to dashboard Cite

show abstract

Is drug-resistant Salmonella typhi an emerging threat?

Cited by 1 publication

References 5 publications

Study on recent trends in antibiogram of enteric fever pathogens in a tertiary care centre in South India

Study on recent trends in antibiogram of enteric fever pathogens in a tertiary care centre in South India

Contact Info

Product

Resources

About