Is duration of exposure a determinant factor for genotoxicity and clinical manifestations induced by Formaldehyde?

Aziz, Manal Abdel; Metwally, Elsayed; Zaki, Eiman I.; Azzaz, Omnia; Hussein, Heba Abdel Samie Mohamed

doi:10.21608/ajfm.2021.135371

Cited by 1 publication

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the frequency of MN was higher in women than in men, but the relationship between gender in both case and control groups and mean percentage of the MN was not significant (P=0.25). This result is consistent with the findings of Abdel Aziz et al (19) and Costa et al (25).…”

Section: Discussionsupporting

confidence: 94%

“…In the present study, the relationship between exposure time during the day and mean percentage of MN in the buccal cells was significant (P=0.03), which is consistent with the findings of Abdel Aziz et al (19). Furthermore, Sivasankarinatarajan et al revealed a positive correlation between time of exposure and carcinogenesis (31).…”

Section: Discussionsupporting

confidence: 92%

“…In our study, the relationship between years of laboratory work (years of exposure) and average percentage of buccal MN was not significant (P=0.17), which is similar to the results of Costa et al in 2008 (25). In contrast, Costa et (3,5,12,19,21,22,28,29). The reason for this discrepancy could be due to the fact that most pathologists decrease their working time, and this can impress our findings.…”

Section: Discussionmentioning

confidence: 65%

“…Furthermore, Sivasankarinatarajan et al revealed a positive correlation between time of exposure and carcinogenesis (31). The results of these studies could indicate that the number of MN increases with extended exposure time during the day (19,31).…”

Section: Discussionmentioning

confidence: 89%

“…This test is one of the most sensitive tests for DNA damage, which is used as one of the most reliable methods to investigate the pathological role of occupational and environmental factors in various human and animal epidemiological studies (6,13,(16)(17)(18). The effect of formaldehyde on the formation of MN has been discussed in previous studies (3,19,20). However, many questions remain unanswered about its frequency.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Formalin Induced Micronucleus Formation in the Buccal Mucosa of Pathology Laboratory Workers

Akhlaghi,

Shahsavari,

Ghorbanpour

2023

Iran J Pathol

View full text Add to dashboard Cite

Scan to discover onlineBackground & Objective: Formaldehyde is an irritating substance that is categorized as a definite carcinogen (Group A1), according to the International Agency for Research on Cancer (IARC). This study was conducted to determine the role of this substance in the frequency of micronuclei (MN) in the buccal mucosal cells due to longterm exposure of the pathology staff to formaldehyde. Methods: In this case-control study, 32 pathology laboratory staff members were assigned to the case group, and 32 staff members who were not exposed to formaldehyde were assigned to the control group. Buccal mucosa cells were collected with a wet spatula and stained with Papanicolaou stain. In each sample, 500 cells were counted; then, the frequency of MN and the average number of MN in the micronucleated cells were assessed and compared between the 2 groups using the independent t test. Furthermore, the relationship between gender and MN was evaluated using the independent t test. The relationship between years of exposure and time of exposure during the day (in hours) for the case group, as well as the relationship between age and frequency of MN was analyzed using the Pearson correlation coefficient. Results:The mean frequency of MN in exfoliated buccal cells was 18.33±12.36 in the case group, which was significantly higher than the control group (10.55±6.22; P=0.003). The difference in the mean number of total MN in the micronucleated cells was not significant between the case and control groups (P=0.11). The relationship between sex, age, and years of exposure with the mean frequency of MN and the total number of MN in the micronucleated cells was not significant. The relationship between exposure time during the day and both the mean frequency of MN and the total number of MN in the micronucleated cells was significant (P=0.03). Conclusion: Formaldehyde exposure and extended time of exposure during the day can increase the frequency of MN, which can prognosticate the incidence of precancerous and cancerous lesions. Therefore, continuous exposure to formaldehyde can be considered an occupational health hazard, though further studies are needed to confirm this result.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%