Is Encephalopathy a Mechanism to Renew Sulfate in Autism?

Abstract

This paper makes two claims: (1) autism can be characterized as a chronic lowgrade encephalopathy, associated with excess exposure to nitric oxide, ammonia and glutamate in the central nervous system, which leads to hippocampal pathologies and resulting cognitive impairment, and (2), encephalitis is provoked by a systemic deficiency in sulfate, but associated seizures and fever support sulfate restoration. We argue that impaired synthesis of cholesterol sulfate in the skin and red blood cells, catalyzed by sunlight and nitric oxide synthase enzymes, creates a state of colloidal instability in the blood manifested as a low zeta potential and increased interfacial stress. Encephalitis, while life-threatening, can result in partial renewal of sulfate supply, promoting neuronal survival. Research is cited showing how taurine may not only help protect neurons from hypochlorite exposure, but also provide a source for sulfate renewal. Several environmental factors can synergistically promote the encephalopathy of autism, including the herbicide, glyphosate, aluminum, mercury, lead, nutritional deficiencies in thiamine and zinc, and yeast overgrowth due to excess dietary sugar. Given these facts, dietary and lifestyle changes, including increased sulfur ingestion, organic whole foods, increased sun exposure, and avoidance of toxins such as aluminum, mercury, and lead, may help to alleviate symptoms or, in some instances, to prevent autism altogether. OPEN ACCESSEntropy 2013, 15 373

Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

“…We have recently proposed that autism can be characterized as a chronic low-grade encephalopathy, where the cascade of events taking place in the brain is a process that enables the renewal of severely depleted sulfate supplies to the brain [277]. We identified a dysbiosis in the gut as a source of ammonia that initiates the encephalytic response, and we proposed glyphosate as one of the many environmental toxins that might be responsible for the dysbiosis and for sulfate depletion.…”

Autism as the Early Closure of a Neuroplastic Critical Period Normally Seen in Adolescence

“…Many potential triggers have been investigated for a causal role in ASD disorders, including sulfate levels [87], serotonin levels [88], pesticide exposure [89], maternal trauma [90], aluminum and acetaminophen [91], oxytocin [92], general diet [11], and mercury poisoning [93]. Most of these studies have demonstrated significant correlations; however, the fact that so many separate factors have a significant role in the development of a set of symptoms, suggests underlying factors may be at play.…”

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

“…up to 100,000-fold lower than those found in antiperspirants, and in the range of those recently measured in the human breast, results in loss of contact inhibition and anchorage-independent growth. This finding should serve as a sentinel warning that environmental Al exposures [252] from dietary [300], parenteral [301], and topical sources [302], may have oncogenic [299,303] and epigenetic [245,253] consequences.…”