Is Endocervical Glandular Involvement Related to The Depth of Cone Biopsy?

Abstract

Introduction. This study aimed to determine whether endocervical glandular involvement by squamous intraepithelial lesion would differ with respect to the depth of the excised specimen and analyze the related factors that may define endocervical glandular involvement among cases treated with cone biopsy. Methods. Between April 2016 and December 2018, women who underwent colposcopy and excisional procedures in the department of gynecologic oncology were retrospectively investigated. Patients with multiple specimens, or whose specimen depths were not measured, and a negative/unknown HPV status were excluded from the study. Also, patients with no dysplasia or microinvasive/invasive cancer in the final pathology report and those who had not undergone endocervical curettage during colposcopy were excluded. HPV genotypes, degree of dysplasia, surgical margin status, and specimen depth were documented from medical records. Further, the association of these factors with endocervical glandular involvement was evaluated. Results: A total of 321 patients who fulfilled the criteria were included in the study, with a mean age of 41.9 years. In total, 101 patients (31.5%) had endocervical glandular involvement. The mean excised specimen depth was 17.04 mm; 17.9 and 16.7 mm for the positive and negative glandular involvement groups, respectively ( p = .13). The mean ages were 42.7 and 41.6 years for these groups, respectively ( p = .32). There was no association between the HPV genotypes and glandular involvement. Conclusions: Endocervical glandular involvement is not associated with the depth of the excised specimen. A deeper cone biopsy may not necessarily enable a more effective treatment of the disease.

Comparison perioperative outcomes for endometrial cancer staging via traditional laparotomy, laparoscopy and robotic-assisted surgery: short term initial experience

“…It is well known that the most important oncological parameter in staging surgery is the total lymph count (32). Depending on the learning curve of the surgeon in TRH and TLH operations, there are studies in the literature (34) in which the total number of lymph nodes in TRH is high. The learning curve of the surgeon, different evaluations among pathologists, and the earlier stage of endoscopic patient groups compared to the TAH group can be counted among the reasons for the low number of total lymph nodes in the patient group we performed minimally invasive surgery (35).…”