Is endometrial monitoring required with the use of long-term unopposed vaginal estrogen?

MacLennan, Alastair H.; Sturdee, David W.

doi:10.1080/13697130600955229

Cited by 4 publications

(2 citation statements)

References 5 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MacLennnan and Sturdee argued that monitoring is not required. 53 There are two elements to their argument. The first is that endometrial screening is costly and has low specificity; the second is that the risk of endometrial cancer after vaginal estrogen use is undefined.…”

Section: Vaginal Estrogen and The Endometriummentioning

confidence: 99%

“…In addition, endometrial cancers often present with vaginal bleeding which makes detection easier. 53 The Cochrane Database does not show evidence of endometrial proliferation or cancers with unopposed low dose vaginal estrogen but there have been no long term studies. It does suggest that progesterone should be added if there is systemic absorption as suggested by administration of greater than 0.5 mg/day.…”

Section: Vaginal Estrogen and The Endometriummentioning

confidence: 99%

See 1 more Smart Citation

Local Effects of Vaginally Administered Estrogen Therapy

Krause¹,

Wheeler²,

Snyder³

et al. 2009

Journal of Pelvic Medicine and Surgery

View full text Add to dashboard Cite

The results of the Women’s Health Initiative (WHI) led to a distinct decline in the routine use of estrogen as preventive therapy for vasomotor symptoms, osteoporosis, and cardiovascular disease in postmenopausal women. Without estrogen replacement, one third of women experience symptoms of atrophic vaginitis including dryness, irritation, itching and or dyspareunia. Local application of estrogen has been shown to relieve these symptoms and improve quality of life for these women. In addition, local estrogen therapy may have a favorable effect on sexuality, urinary tract infections, vaginal surgery, and incontinence. This review examines the effects of vaginally applied estrogen on the vaginal epithelium, urethra and endometrium. An accompanying review examines the systemic effects of vaginally applied estrogen.

show abstract

Section: Vaginal Estrogen and The Endometriummentioning

confidence: 99%

Section: Vaginal Estrogen and The Endometriummentioning

confidence: 99%