Is fecal microbiota transplantation (<scp>FMT</scp>) an effective treatment for patients with functional gastrointestinal disorders (<scp>FGID</scp>)?

Pinn, David M.; Aroniadis, Olga C.; Brandt, Lawrence J.

doi:10.1111/nmo.12479

Cited by 82 publications

(67 citation statements)

References 109 publications

(187 reference statements)

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“…33 In IBS patients, alteration of intestinal microbiota has been linked to immune dysfunction and altered neurological functions, such as reduced pain threshold and increased anxiety, suggesting that restoration of normal intestinal homeostasis via FMT may result in symptomatic improvement. 34 Our results confirmed that FMT delivered through an NJ tube may relieve abdominal pain and bloating symptoms in CIPO patients. The microbiota plays a key role in the development and promotion of normal gut neuromotor function.…”

supporting

confidence: 78%

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

Ding

Tian

et al. 2017

J Neurogastroenterol Motil

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Background/AimsChronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigated the efficacy of FMT in the treatment of CIPO patients. MethodsNine patients (age 18-53 years) with CIPO were enrolled in this prospective, open-label study. Patients received FMT for 6 consecutive days through nasojejunal (NJ) tubes and were followed up for 8 weeks after treatment. We evaluated the rate of clinical improvement and remission, feeding tolerance of enteral nutrition, and CT imaging scores of intestinal obstructions. Lactulose hydrogen breath tests were performed before FMT and 8 weeks after FMT to evaluate for the presence small intestinal bacterial overgrowth (SIBO). ResultsFMT significantly alleviated bloating symptoms, and symptoms of pain were relieved 2 weeks after FMT. Enteral nutrition administered through a NJ tube after FMT was well-tolerated by 66.7% (6/9) of patients. CT scores of intestinal obstructions were significantly reduced after FMT (P = 0.014). SIBO was eliminated in 71.0% (5/7) of patients. ConclusionsThis pilot study demonstrated the safety of using FMT. FMT may relieve symptoms in selected patients with CIPO. FMT may also improve patient tolerance of enteral nutrition delivered via a NJ tube.

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supporting

confidence: 78%

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

Ding

Tian

et al. 2017

J Neurogastroenterol Motil

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“…O TMF também tem sido evidenciado como alternativa de forma eficaz para outras doenças do trato GI, como a doença inflamatória do intestino, a síndrome do intestino irritável, a prisão de ventre crônica, entre outras patologias GI. Os sintomas são caracterizados pela diarreia predominante ou constipação predominante ou, ainda, ambos os sintomas, com ausência de quaisquer anomalias anatômicas ou exames bioquímicos identificáveis (29). Estas alterações podem estar relacionadas com a modificação da microbiota intestinal e possibilidade de alívio dos sintomas e cura da doença pode ser através do TMF.…”

Section: Resultsunclassified

A Eficácia Do Tratamento Da Obesidade Através Do Transplante Da Microbiota Fecal De Indivíduos Magros

Penteado

Salgado

Barlem

2017

VITTALLE, ISSN 1413-3563, Rio Grande, Brasil

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RESUMOHá um crescente interesse na compreensão do papel da microbiota intestinal para elucidar o seu potencial terapêutico. Uma das possíveis aplicações do transplante da microbiota fecal é no tratamento da obesidade, também denominado bacterioterapia fecal. Dessa forma, o objetivo do trabalho foi compreender o efeito terapêutico da microbiota intestinal na saúde do indivíduo. Assim como, conhecer a aplicação do transplante da microbiota fecal de indivíduos magros em indivíduos obesos. Tratou-se de uma revisão integrativa da literatura. A busca dos artigos foi realizada em abril de 2016, no Portal Regional da Biblioteca Virtual da Saúde, no período 2006-2016. Foram utilizados como critérios de inclusão: artigos disponíveis na íntegra de acesso livre; que abordaram a temática do estudo; apresentação de resumo; em língua portuguesa, inglesa ou espanhola. Dentre os descritores de ciências da saúde, utilizou-se "gastrointestinal microbiome", "fecal microbiota transplantation" e "obesity". Os artigos apresentaram como principal resultado mais encontrado que o transplante da microbiota fecal do indivíduo magro para o indivíduo obeso pode ser usado no tratamento de várias doenças tais como infecções intestinais ou em Diabetes Mellitus. Portanto, faz-se necessário a divulgação do tema em um âmbito multiprofissional facilitando o aumento de pesquisas em todas as áreas e um maior conhecimento sobre o assunto. Evidências atuais em humanos corroboram estudos em modelos animais para o tratamento da obesidade através desta técnica. Porém, os estudos ainda são escassos, dificultando a formulação de recomendações para a prática profissional. The efficacy of obesity through fecal microbiota transplantation of individuals skinnyABSTRACT -There is a growing interest in understanding the role of the intestinal microbiota to elucidate its therapeutic potential. One of the possible application of the fecal microbiota transplantation is the treatment of obesity, also called as fecal bacteriotherapy. Thus, the objective of this study was to understand the therapeutic effect of intestinal microbiota on the health of the individual. As well as, to know the application of transplantation of fecal microbiota of lean individuals in obese individuals. It was an integrative literature review.

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“…116 The increasingly appreciated role of gut microbiota in the pathogenesis of FBDs and the imperfect current treatment can promote the use of FMT in selected patients with FBDs. [117][118][119] To date, few case series have reported outcomes of FMT for constipation and IBS, 120,121 but the results are promising. In a recent small study of FMT for refractory IBS (total of 13 patients: 9 IBS-D, 3 IBS-C, and 1 mixed IBS), a fecal suspension was infused into the distal duodenum or proximal jejunum via upper endoscopy.…”

Section: Fecal Microbiota Transplantationmentioning

confidence: 99%

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

Lee

Choi

Ryu

et al. 2017

J Neurogastroenterol Motil

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Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation.

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Is fecal microbiota transplantation (FMT) an effective treatment for patients with functional gastrointestinal disorders (FGID)?

Abstract: This review aims to investigate the role of intestinal microbiota in the pathogenesis of FGID, the implications of FMT for the treatment of FGID, and the challenges encountered in measuring response to a specific intervention in patients with FGID.

Cited by 82 publications

References 109 publications

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study

A Eficácia Do Tratamento Da Obesidade Através Do Transplante Da Microbiota Fecal De Indivíduos Magros

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

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