Ultrasound-guided pericapsular nerve group block (PENG) and fascia iliac compartment block (FICB) are alternative methods of pain relief during lower limb orthopedic surgery. However, the efficacy and safety of PENG compared with FICB have not been fully established.We comprehensively searched randomized controlled trials (RCTs) about comparing PENG with FICB for patients with lower limb orthopedic surgery through the databases of Pubmed, Embase, Cochrane Library, CNKI and Wanfang database with no limitation of language from their inception date to December 2022. Two reviewers were independently involved in the process of data extraction. The main outcome measures were pain scores in resting state and exercise state at different time points. Secondary outcome indexes were the first analgesia time, intraoperative remfentanil consumption, fentanyl consumption at 24 hours after surgery, morphine consumption at 24 hours after surgery, satisfaction score for postoperative analgesia, quadriceps muscle strength at 6 and 24 hours after surgery, incidence of adverse reactions such as nausea and vomiting. The Rev Man 5.3 software was used for meta-analysis of the data.Finally, a total of 8 RCTs with 210 patients in PENG group and 201 patients in FICB group were included in this meta-analysis. Pooled analysis indicated that there were no significant differences between the two groups in resting state and exercise state pain scores before nerve block and postoperative incidence of nausea and vomiting (P>0.05). Compared with FICB, pain scores at 10nim, 20min and 30min after nerve block, at 6h, 12h, 24h and 48h after surgery at resting state and exercise state, intraoperative remifentanil consumption, total sufentanil consumption and morphine consumption at 24h after surgery were significantly reduced in PENG group (P<0.05). In addition, compared with FICB group, the first postoperative analgesia time, postoperative analgesia satisfaction score, and quadriceps muscle strength 6h and 24h after surgery were significantly improved in PENG group (P<0.05) .Existing clinical evidence shows that compared with FICB , ultrasus-guided PENG has better analgesic effect in lower limb orthopedic surgery, patients need less intraoperative and postoperative opioid analgesic drugs, the duration of analgesia is longer, the effect on postoperative lower limb muscle strength of patients is less, and the occurrence of adverse reactions of nausea and vomiting is not increased.