Is Fever in Man Reflected in Changes in Cerebrospinal Fluid Concentrations of Sodium and Calcium Ions?

Nielsen, B.S.; Schwartz, Pamela F.; Alhede, J.

doi:10.3109/00365517309084352

Cited by 8 publications

(1 citation statement)

References 4 publications

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“…A major question pertains to the relationship between the displacement in core temperature seen during strenuous exercise and the function of endogenous calcium ions in the brain. In peripheral studies, both Nielsen, Schwartz & Alhede (1973) and Greenleaf, Kolzowski, Nazar, Kaciuba-Uscilko, Brzesinkska & Ziemba (1976) have shown that a change in the concentration ofplasma calcium markedly affects the body temperature of the exercising animal. Moreover, the magnitude of the hyperthermia produced by exercise in both the rat and dog, can be attenuated significantly by a direct intracerebral injection or perfusion of a solution 618 Ca2+, EXERCISE AND BODY TEMPERATURE containing excess calcium (Gisolfi, Wilson, Myers & Phillips, 1976;Sobocinska & Greenleaf, 1976).…”

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Diencephalic efflux of calcium ions in the monkey during exercise, thermal stress and feeding

Gisolfi¹,

Mora²,

Myers³

1977

The Journal of Physiology

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SUMMARY1. The diencephalon of the unanaesthetized macaque monkey was radio-labelled with calcium by a microinjection of [6][7][8] ,uC 45Ca2+ into the third cerebral ventricle through a permanently implanted cannula. Successive 5 min push-pull perfusions of the mid-line hypothalamic region with an artificial C.S.F. were carried out at a rate of 28,ul./min every 20 mi. A washout curve of declining 4Ca2+ radioactivity was thus generated.2. When the monkey exercised strenuously on a special 'rowing machine' to obtain highly palatable banana pellets, its body temperature rose sharply. As the monkey exercised, during a sequence of push-pull perfusions, the concurrent efflux of "Ca2+ ions increased markedly in the corresponding samples of diencephalic perfusate. This enhanced activity of calcium ions continued throughout a 30 min work period and persisted as long as the monkey's temperature was elevated in the interval immediately following exercise.3. Exposure of the monkey's trunk, between neck and thigh to cold air of 5 0C likewise augmented the amount of 45Ca2+ ions in the diencephalic push-pull perfusates; however, a similar exposure to air warmed to 35 0C failed to alter the pattern of 45Ca2+ efflux from the animal's diencephalon. If a fasted monkey consumed only the banana pellets but was not exercised, the level of 45Ca2+ in the perfusate also increased transiently, just at the onset of feeding. 4. We conclude that a local change in calcium transport, binding or other cellular activity of the cation within the diencephalon could play an important role in the central mechanism underlying the set-point rise in a primate's temperature which accompanies vigorous exercise. C. V. GISOLFI, F. MORA AND R. D. MYERS the results support the idea that this cation functions in the diencephalic control of metabolic heat production as well as in the overall processes of energy metabolism, particularly in relation to feeding.

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