Is fibromyalgia an autoimmune illness?

Martı́nez-Lavı́n, Manuel

doi:10.1007/s10067-021-05888-0

Cited by 10 publications

(10 citation statements)

References 18 publications

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“…According to the study, the IgG isolated were found to hyperstimulate nociceptive afferents in the dorsal root ganglia responsible for the hypersensitivity to pain stimuli seen in fibromyalgia. Accordingly, we agree with Martinez-Lavin, who addressed fibromyalgia as possibly an autoimmune disease, stressing the importance of further investigations and the need for scientific-based evidence [ 35 ].…”

Section: Fibromyalgiasupporting

confidence: 83%

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Mahroum

Shoenfeld

2022

Pathophysiology

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The pathophysiological mechanisms involved in chronic disorders such as complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms, and post-COVID syndrome have not been clearly defined. The course of the pain in some of the syndromes, the absence of evident tissue damage, and the predominance of alterations in the autonomic nervous system are shared similarities between them. The production of autoantibodies following a trigger in the syndromes was previously described, for instance, trauma in complex regional pain syndrome, infectious agents in fibromyalgia, chronic fatigue syndrome, and post-COVID syndrome, and the immune stimulation by silicone in women with breast implants. In fact, the autoantibodies produced were shown to be directed against the autonomic nervous system receptors, leading to the amplification of the perception of pain alongside various clinical symptoms seen during the clinical course of the syndromes. Therefore, we viewed autoantibodies targeting the autonomic nervous system resulting in autonomic dysfunction as likely the most comprehensive explanation of the pathophysiology of the disorders mentioned. Based on this, we aimed to introduce a new concept uniting complex regional pain syndrome, fibromyalgia, chronic fatigue syndrome, silicone breast implant–related symptoms, and post-COVID syndrome, namely “autoimmune autonomic dysfunction syndromes”. Due to its etiological, pathophysiological, and clinical implications, the suggested term would be more precise in classifying the syndromes under one title. The new title would doubtlessly facilitate both laboratory and clinical studies aimed to improve diagnosis and make treatment options more directed and precise.

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Section: Fibromyalgiasupporting

confidence: 83%

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Mahroum

Shoenfeld

2022

Pathophysiology

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“…11 Fibromyalgia patients have also sympathetic hyporeactivity to different stressors, theoretically explaining ongoing fatigue. 12 Additional environmental stressors such as COVID-19 lockdown-associated lifestyle changes could worsen sympathetic nervous system dysfunction. Contrary to what happens normally, fibromyalgia patients have norepinephrine-evoked pain.…”

Section: Discussionmentioning

confidence: 99%

Effect of COVID-19 Pandemic Lockdown on Fibromyalgia Symptoms

et al. 2022

Self Cite

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“…Similar issues have been raised in the context of FM and ME/CFS (29,30). However, while FM and ME/CFS technically remain medically unexplained, extensive progress has been made in the search for biomarkers of these conditions (14,(31)(32)(33)(34)(35)(36). Renewed interest has emerged in the wake of the SARS-CoV-2 pandemic: not only are there remarkable similarities between Long-Covid and ME (37,38), preliminary evidence suggests that FM may emerge as part of the post-Covid syndrome (39)(40)(41).…”

Section: Introductionmentioning

confidence: 80%

Patient and clinician experiences of fibromyalgia, ME/CFS and medically unexplained symptoms: A meta-aggregative systematic review

Duda¹,

Maguire²,

Gitonga³

et al. 2023

Preprint

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Objectives: Fibromyalgia (FM), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and other syndromes with medically unexplained symptoms (MUS) pose significant healthcare challenges. We aimed to synthesize qualitative evidence regarding the experiences of persons with these conditions (PwC) and their healthcare professionals (HCPs).Methods & Measures: Databases were searched using terms relating to FM/ME/CFS/MUS, Experience and Qualitative research. Studies published between 2001-2021 concerning adult PwC or HCP perspectives were included and synthesized using Meta-Aggregation, with confidence established following the ConQual approach.Results: 143 studies were included, with 708 findings aggregated into 82 categories and 13 synthesized findings. PwC narratives reflected a range of themes concerning: The experience of symptoms; The patient journey; Identity loss and change; Managing chronic illness; Understanding and legitimacy; Support needs and experiences; Healthcare needs and experiences; and Managing the healthcare encounters. HCPs perspective themes included: Beliefs and attitudes towards patients; Sensemaking at the limits of medical knowledge; Consultation and management; The patient-clinician relationship; and Barriers and facilitators to care. Conclusion: Sensemaking challenges are at the core of the patient and clinician experience of MUS, FM and ME/CFS. While gaps in biomedical knowledge are clear, this review highlights the need to address the patient-clinician dynamic in the context of uncertainty.

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Is fibromyalgia an autoimmune illness?

Cited by 10 publications

References 18 publications

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Autoimmune Autonomic Dysfunction Syndromes: Potential Involvement and Pathophysiology Related to Complex Regional Pain Syndrome, Fibromyalgia, Chronic Fatigue Syndrome, Silicone Breast Implant–Related Symptoms and Post-COVID Syndrome

Effect of COVID-19 Pandemic Lockdown on Fibromyalgia Symptoms

Patient and clinician experiences of fibromyalgia, ME/CFS and medically unexplained symptoms: A meta-aggregative systematic review

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