Is food refusal in autistic children related to TAS2R38 genotype?

Riccio, Maria Pia; Franco, Chiara; Negri, Rossella; Ferrentino, R; Maresca, Roberta; D'alterio, Elisa; Greco, Luigi; Bravaccio, Carmela

doi:10.1002/aur.1912

Cited by 34 publications

(28 citation statements)

References 42 publications

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“…Sendo assim, um dos principais desafios é avaliar os fatores sensoriais e padrões alimentares restritivos e repetitivos em crianças com autismo, para determinar quais as abordagens devem ser adotadas da maneira mais precoce possível (YAMANE; FUJII; HIJIKATA, 2020). A intervenção precoce auxilia em tornar alimentos mais palatáveis, garantindo assim uma adequada oferta de fatores nutricionais, principalmente no início da infância (RICCIO et al, 2018).…”

Section: Discussionunclassified

“…No TEA, a severidade da recusa e a persistência em certos alimentos se devem principalmente à ativação de padrões específicos da sensibilidade gustativa e características neuropsicológicas típicas do transtorno, como a rigidez comportamental (RICCIO et al, 2018). A recusa alimentar apresentada por diversos indivíduos na amostra coloca-os em situação de atenção nutricional, considerando as possíveis carências nutricionais que essas pessoas podem apresentar, afetando diretamente seu estado nutricional.…”

Section: Discussionunclassified

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Aspectos alimentares e nutricionais de crianças e adolescentes com transtorno do espectro autista

Magagnin

Silva

Nunes

et al. 2021

Physis

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Resumo Objetivo: Compreender os hábitos, dificuldades e as estratégias alimentares de crianças e adolescentes com transtorno do espectro autista (TEA). Método: Trata-se de pesquisa de abordagem qualitativa do tipo exploratória e descritiva, realizada com 14 pais cujos filhos frequentam uma escola de educação especial especializada na educação de pessoas com TEA localizada em uma cidade do extremo sul catarinense, por meio de entrevista semiestruturada, com uso da análise de conteúdo temática. Resultados: Os dados coletados indicaram três categorias temáticas: hábitos alimentares de crianças e adolescentes com TEA; dificuldades alimentares de crianças e adolescentes com TEA; e estratégias alimentares para crianças e adolescentes com TEA. As crianças e adolescentes autistas possuem um considerável consumo de alimentos processados e ultraprocessados, além de comportamentos relativos à recusa alimentar, disfagia, baixa aceitação de alimentos sólidos, compulsão alimentar e sintomas gastrointestinais. Foi possível identificar também uma lacuna no conhecimento dos cuidadores relacionados aos aspectos sensoriais do transtorno envolvidos nos hábitos alimentares de seus filhos. Conclusão: As crianças e adolescentes com TEA apresentam uma alimentação diversificada, com tendência a hábitos alimentares disfuncionais e significativo comprometimento nas atividades sensoriais que dificultam a obtenção e o estabelecimento de uma alimentação saudável.

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Section: Discussionunclassified

Aspectos alimentares e nutricionais de crianças e adolescentes com transtorno do espectro autista

Magagnin

Silva

Nunes

et al. 2021

Physis

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“…Likewise, Bandini et al found that FFQ data revealed children with ASD refuse more vegetables than TD children [42]. In agreement with this, a study found that food refusal in children with ASD may in some cases be due to a bitter taste sensitivity associated with the TAS2R38 genotype [47]. Although little research has investigated the implications of polymorphisms in taste receptors and feeding behaviors in ASD, previous research has demonstrated that TD children exhibit two sensitive alleles for bitter taste had a lower threshold concentration to detected sucrose and a greater sugar consumption compared to children with less sensitive alleles [48].…”

Section: Feeding Behaviormentioning

confidence: 78%

Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder

Dhaliwal

Orsso

Richard

et al. 2019

IJMS

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Autism Spectrum Disorder (ASD) is a developmental disorder characterized by social and communication deficits and repetitive behaviors. Children with ASD are also at a higher risk for developing overweight or obesity than children with typical development (TD). Childhood obesity has been associated with adverse health outcomes, including insulin resistance, diabetes, heart disease, and certain cancers. Importantly some key factors that play a mediating role in these higher rates of obesity include lifestyle factors and biological influences, as well as secondary comorbidities and medications. This review summarizes current knowledge about behavioral and lifestyle factors that could contribute to unhealthy weight gain in children with ASD, as well as the current state of knowledge of emerging risk factors such as the possible influence of sleep problems, the gut microbiome, endocrine influences and maternal metabolic disorders. We also discuss some of the clinical implications of these risk factors and areas for future research.

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“…Aberrant EBs are complex issues of ASD. Riccio's research proved that aberrant EBs, in particular food selectivity was mediated by taste sensitivity which related to TAS2R38 genotype ( 21 ). Messina's study presented that the rule of sympathetic activity was very important for ASD, neurotransmitters alterations could explain food selectivity ( 22 ), and further study could broaden horizons to multi-modal approach.…”

Section: Discussionmentioning

confidence: 99%

Study on Aberrant Eating Behaviors, Food Intolerance, and Stereotyped Behaviors in Autism Spectrum Disorder

Liu

Fang

et al. 2020

Front. Psychiatry

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Objective: To investigate the aberrant eating behaviors (EBs), gastrointestinal (GI) symptoms, and food intolerance in children with autism spectrum disorder (ASD) and their association with clinical core symptoms of ASD. Method: A total of 94 preschool children with ASD treated at the Child Mental Health Research Center of Nanjing Brain Hospital between October 2016 and April 2018 were enrolled. In addition, 90 children with typical development (TD) in the community during the same period were recruited. The conditions of aberrant EBs and GI symptoms in children were investigated using questionnaire surveys. Serum specific IgG antibodies against 14 kinds of food were detected using enzyme-linked immunosorbent assays (ELISAs). Results: The detection rate of aberrant EBs in the ASD group was significantly higher than that in the TD group (67.39 vs. 34.94%), and the rate of GI symptoms was also higher in the ASD group than that in the TD group (80.22 vs. 42.11%). Detection of food intolerance in children with ASD showed that the positive rate was 89.89% and that the majority of children had multiple food intolerances. The correlation analysis results showed that the severity of aberrant EBs positively correlated with stereotyped behavior of children with ASD (r = 0.21, P = 0.04) and that food-specific IgG antibodies concentrations positively correlated with high-level stereotyped behavior in children with ASD (r = 0.23, P = 0.03). Conclusion: ASD with aberrant EBs or high food-specific IgG antibodies concentrations had more severe stereotyped behavior, which may have implications for exploring the immune mechanism of ASD. Clinical Trial Registration: ChiCTR-RPC-16008139.

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Is food refusal in autistic children related to TAS2R38 genotype?

Cited by 34 publications

References 42 publications

Aspectos alimentares e nutricionais de crianças e adolescentes com transtorno do espectro autista

Aspectos alimentares e nutricionais de crianças e adolescentes com transtorno do espectro autista

Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder

Study on Aberrant Eating Behaviors, Food Intolerance, and Stereotyped Behaviors in Autism Spectrum Disorder

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