Is Gardner-Diamond Syndrome related to autoimmunity?

Temiz, Selami Aykut; Işık, Begüm; Özer, İlkay; Ataseven, Arzu

doi:10.14744/nci.2020.97992

Cited by 5 publications

(7 citation statements)

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“…Rosacea and cutaneous flushing can also be associated with somatic symptoms too 35 . Gardner‐Diamond syndrome (GDS) is the clinical picture of painful cutaneous and mucosal ecchymoses in women 38 . The exact cause of the disease is unclear and some consider it to be a somatoform disorder 38 .…”

Section: Somatization and Psoriasismentioning

confidence: 99%

“… 35 Gardner‐Diamond syndrome (GDS) is the clinical picture of painful cutaneous and mucosal ecchymoses in women. 38 The exact cause of the disease is unclear and some consider it to be a somatoform disorder. 38 More recently, antibodies against phosphatidylserine in erythrocyte stroma have been detected, perhaps causing immune complexes and complement activation in GDS, suggest a possible autoimmune pathogenesis instead.…”

Section: Somatization and Psoriasismentioning

confidence: 99%

“… 38 More recently, antibodies against phosphatidylserine in erythrocyte stroma have been detected, perhaps causing immune complexes and complement activation in GDS, suggest a possible autoimmune pathogenesis instead. 38 …”

Section: Somatization and Psoriasismentioning

confidence: 99%

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Somatization in dermatology

Millington

Shobajo

Wall³

et al. 2022

Skin Health and Disease

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Medically unexplained dermatologic symptoms, such as pruritus, numbness and burning are known as somatization. These cutaneous symptoms can be very difficult to treat because of an absence of an objective explanation and they may not fit neatly into any known dermatological or psychiatric condition. These disorders are more commonly encountered in primary care and in dermatology, rather than in psychiatry. Certain skin disorders, for example, pruritus, could be a manifestation of somatization and others may predispose to somatic symptoms, for example, atopic dermatitis and psoriasis. Although there has been increasing research in the interconnection between psychiatry and dermatology, psychodermatology is a relatively new crossover discipline in clinical practice and recognition of psychodermatological conditions, such as cutaneous somatic disorders, can be difficult. Somatization may occur with or without the existence of a dermatological disease. When a dermatological disorder is present, somatization should be considered when the patient is worrying too much about their skin, spending too much time and energy on it and especially if the patient also complains of many non‐cutaneous symptoms. Purely cutaneous somatic conditions include for example, the genital pain syndromes or Gardner–Diamond syndrome, characterized by unexplained bruising, which usually affects women. Effective management tools may include mindfulness therapies, pharmacotherapy with selective serotonin reuptake inhibitors, tricyclic antidepressants and cognitive conduct therapy. Electroconvulsive therapy can also be considered in extremely rare cases for treatment of severe somatization on a background of mood disorders. This paper discusses somatization, its relationship to immunodermatoses and its relevance to clinical practice.

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Section: Somatization and Psoriasismentioning

confidence: 99%

Section: Somatization and Psoriasismentioning

confidence: 99%

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Somatization in dermatology

Millington

Shobajo

Wall³

et al. 2022

Skin Health and Disease

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“…The experimental results found that the friction coefficient increased with increasing sliding speed and the temperature increase was also observed with increasing sliding distance. Temiz, 28 evaluated the tribological performances of the samples made of cast POM, cast PA, UHMWPE, PTFE + 15% glass fiber, PTFE + 25% carbon, PTFE + 35% carbon, PTFE + 40% bronze and PTFE + 60% materials in the journal bearing test rig. As a result of the experiments, it was observed that the friction coefficient increased with increasing sliding speed in 15% glass fiber reinforced PTFE and decreased under some load conditions in 25% glass fiber reinforced PTFE.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the tribological properties of POM and UHMWPE radial journal bearings made with different surface quality

Artun,

Azeloglu,

Taylan

2023

Proceedings of the Institution of Mechanical Engineers, Part J:

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Journal bearings are essential machine elements that are widely used in the bearing of rotating or oscillating machine parts. Many studies in the literature examine the tribological properties of journal bearings. Most of these studies focus on polymer journal bearings and testing the tribological performances of different bearing materials with the same surface quality. In this article, radial journal bearings produced from ultra-high molecular weight polyethylene (UHMWPE) material and polyoxymethylene (POM) material in two different surface qualities in the range of N7–N8 and N10–N11 were tested under different load and different speed scenarios and their tribological performances and relationship of this performance between material and surface roughness were investigated. For this purpose, first of all, bearing samples were designed and manufactured. All samples’ tribological and physical properties before the tests were measured, and then tests were carried out according to the determined scenarios. Different loads, different speeds, and different sliding distances were used in the scenarios. As a result, 96 tests were carried out by testing each situation three times in eight scenarios, with two different surface qualities from two different materials. In the tests, the friction coefficient, temperature, and weight loss values of all samples were measured, and after the tests, surface roughness measurements and SEM analyses were made. As a result, all the data obtained from the tests and measuring devices were compared with the pre-test conditions and material and surface quality. The results obtained from the comparisons and the evaluations of tribological performance are discussed in the conclusion part. The study results show that the material and the surface quality significantly affect the tribological performance.

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“…The first case of autosensitization to a patient’s own blood was described by Gardner and Diamond [ 1 ], though PP-like dermatological manifestations of psychological factors have been described earlier by Schindler [ 2 ], where hypnosis of patients resulted in skin hemorrhages, and Jacobi [ 3 ], where patients with psychiatric comorbidities demonstrated purpura. Although the exact pathophysiology is unknown, it is hypothesized to be caused by psychological stress, estrogen, autoimmunity [ 4 ], low serotonin [ 5 ], and even religious “Holy Stigmata” [ 6 ]. It predominantly affects the young female demographic for reasons that remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Diagnosing the Dermatologic Blues: Systematic Review of the Rare Conundrum, Psychogenic Purpura

Gill,

Zeglinski-Spinney

2023

JMIR Dermatol

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Background Psychogenic purpura is an idiopathic psychodermatologic condition of recurrent, painful purpura precipitated by psychological stress, predominantly affecting young females. Little consensus exists on the diagnostic guidelines for this rare condition, often resulting in costly, unnecessary, and stressful investigations as well as prolonged hospital admissions. Objective With this first up-to-date systematic review of 134 cases of psychogenic purpura in over a decade, we aim to thoroughly investigate the diagnostic strategy and treatment regimens used in the last decade. With a sooner diagnosis, patient stress and nosocomial ecchymoses can be minimized, and treatment can be expedited. Methods We conducted a literature review of 4 databases (PubMed, Ovid Embase, Ovid MEDLINE, and Web of Science) on October 5, 2022 that yielded 46 full-text articles, which were reviewed and extracted by 2 independent reviewers. Results We analyzed a total of 134 cases, consisting largely of females (125/134, 93.3%) with purpura on the upper (103/134, 76.9%) or lower limbs (112/134, 83.6%). Apart from a paresthesia prodrome, patients commonly experienced headaches, malaise, and arthralgia or myalgia. Approximately 70% (95/134) of patients reported a physiological or psychological stressor or psychiatric diagnosis before the development of the purpura. Laboratory testing almost always revealed unremarkable results. The intradermal washed autoerythrocyte sensitization test was positive in 98% (42/43) of cases. Histopathology biopsy findings commonly revealed dermal erythrodiapedesis or hemorrhage (n=34) and perivascular inflammatory infiltrates (n=17). Approximately 42% (56/134) of patients received a novel psychiatric diagnosis, with depression being the most common (40/72, 56%). In both patients with and those without a novel psychiatric diagnosis, observation, counseling, treatment with antidepressants (ie, selective serotonin reuptake inhibitors), and psychotherapy (ie, cognitive behavioral therapy) prevailed in the resolution of the purpura. Conclusions Due to the unclear etiology and infrequent presentation of this condition, it remains a diagnosis of exclusion based on clinical suspicion evaluating the presence of stressors or psychiatric comorbidities and exclusion of systemic conditions. Clinical confirmation can be sought through a positive autoerythrocyte sedimentation test, characteristic histopathology findings, and remission of purpura after psychiatric treatment.

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Is Gardner-Diamond Syndrome related to autoimmunity?

Cited by 5 publications

References 0 publications

Somatization in dermatology

Somatization in dermatology

Investigation of the tribological properties of POM and UHMWPE radial journal bearings made with different surface quality

Diagnosing the Dermatologic Blues: Systematic Review of the Rare Conundrum, Psychogenic Purpura

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