Is Gastrointestinal Metastasis of Primary Lung Malignancy as Rare as Reported in the Literature? A Comparison Between Clinical Cases and Post-mortem Studies

Jevremovic, Vasa

doi:10.17925/ohr.2016.12.01.51

Cited by 11 publications

(15 citation statements)

References 36 publications

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“…The incidence of gastrointestinal metastasis of primary lung cancer ranges from 0.3 to 1.7% [ 7 ]; however, in postmortem studies, the incidence ranges from 4.6 to 14% [ 7 , 8 ]. This discrepancy indicates that most of the patients have asymptomatic gastrointestinal metastases.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Colonic Metastasis of Primary Lung Cancer

et al. 2021

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The colon is an uncommon secondary site for metastasis of lung adenocarcinoma. Distinguishing primary colonic carcinoma from metastatic spread of lung carcinoma can be difficult. We present a case of a patient with lung adenocarcinoma who, on abdominal computed tomography scan examination, was found to have a sigmoid tumor that was thought to represent a synchronous primary colorectal adenocarcinoma. Histological examination of endoscopic sigmoid tumor biopsies confirmed this to be metastasis from the lung adenocarcinoma. The patient subsequently developed major rectal bleeding and deteriorated significantly. This case also illustrates the poor prognosis association with colorectal metastasis of lung cancer.

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Section: Discussion/conclusionmentioning

confidence: 99%

Colonic Metastasis of Primary Lung Cancer

et al. 2021

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“…Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in unconventional indications is occasionally reported in experienced tertiary centers [2], most frequently from rare ovarian cancers, sarcoma, or neuroendocrine tumors, and, more rarely, from gastrointestinal stromal tumor (GIST), hepatocellular and cholangiocarcinoma and desmoplastic small round cell tumors. The gap existing between the small reported series data and the incidence rates in autopsy series could suggest that in most cases peritoneal metastases from lung cancer remain clinically silent [16]. Our results on these two patients might help in stimulating more awareness of this condition and in suggesting a strict follow-up: in fact, early diagnosis of peritoneal diffusion, which is probably often underrated, could allow a radical cytoreductive surgery providing some advantages to survival.…”

Section: Discussionmentioning

confidence: 81%

“…The prognosis for patients with peritoneal metastases from lung cancer is very poor regardless of the treatment, with a median survival rate of 2 to 4 months. In a recent review, Balla et al found two cases of peritoneal metastases out of a sample of 91 patients with lung cancer with gastrointestinal metastases: the disparity with autopsy series suggests that most cases are asymptomatic or unreported [16, 17]. Emergency surgery for bowel obstruction and extra-abdominal metastases, found in up to 60% of patients [11, 12], could be the main reasons for the poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literature

et al. 2019

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Background Peritoneal metastases are often reported in several abdominal tumors. Peritoneal diffusion from extra-abdominal tumors is thought to be rare. Lung cancer is one of the most common cancers in the world with early metastases and it is associated with poor prognosis in advanced stages. Peritoneal metastases from lung cancer are uncommon and the real mechanism of its diffusion to the peritoneum is unknown. However, its clinical behavior is similar to any other peritoneal metastasis from abdominal tumors. Case presentation We present two Caucasian patients (a 44-year-old man and a 59-year-old man) with bowel obstruction from peritoneal metastases from non-small cell lung cancer who successfully underwent emergency cytoreductive surgery and had a good prognosis and survival. Conclusions In our patients with isolated peritoneal metastases from lung cancer, cytoreduction showed good prognosis with acceptable morbidity. This treatment option might be considered in highly selected cases to improve survival. Strict follow-up is mandatory to allow early diagnosis of peritoneal diffusion.

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“…The majority of patients with intestinal metastases from primary lung are asymptomatic. 6 This finding has led to a discrepancy between the estimated incidence in clinical and postmortem studies. 18 This clinical underdiagnosis likely occurs because the intestinal symptoms experienced by the patient overlap with the adverse effects of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Different studies have reported that GI metastases from primary lung cancer are infrequent, with an incidence ranging between 0.3% and 1.7%. 6 Intestinal metastases may be asymptomatic and include obstruction, perforation, occult bleeding, and intussusception. Symptomatic intestinal metastases may be life-threatening and necessitate emergency surgery.…”

Section: Introductionmentioning

confidence: 99%

Intestinal metastasis from primary<em> ROS1</em>-positive lung adenocarcinoma cancer patients responding to crizotinib

Chen¹,

Zhang

Zhu³

et al. 2018

OTT

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Small intestinal metastases from primary lung cancer are rare. Such patients have a poor prognosis. Early diagnosis of small intestinal metastases is difficult because of the low incidence of clinically apparent symptoms. The standard treatment for small intestinal metastases has not been established. A 69-year-old Chinese man presented for evaluation of a tumor in the right lower lung and mediastinal lymph node enlargement on clinical examination. The clinical stage was cT2N2M0 (stage IIIA). Histologic examination of the tumor revealed lung adenocarcinoma. He could not tolerate surgery; hence, he received two chemotherapy regimens. However, the disease progressed. He had bloating after chemotherapy and decreased flatus. An abdominal CT scan showed an intestinal effusion with local intestinal obstruction. Medical treatment was ineffective; hence, he underwent a diagnostic laparoscopy. The pathologic evaluation suggested an intestinal metastatic adenocarcinoma from the primary lung cancer. Based on an real-time PCR assay, the tumor had a ROS1 fusion and responded well to crizotinib. The progression-free survival was 7 months. Physicians must be aware of the possibility of intestinal metastases from primary lung cancer. With an accurate diagnosis and thorough evaluation, patients may benefit from targeted therapy.

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Is Gastrointestinal Metastasis of Primary Lung Malignancy as Rare as Reported in the Literature? A Comparison Between Clinical Cases and Post-mortem Studies

Cited by 11 publications

References 36 publications

Colonic Metastasis of Primary Lung Cancer

Colonic Metastasis of Primary Lung Cancer

Surgical treatment of intraperitoneal metastases from lung cancer: two case reports and a review of the literature

Intestinal metastasis from primary<em> ROS1</em>-positive lung adenocarcinoma cancer patients responding to crizotinib

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