Is gestational diabetes mellitus in obese women predicted by oxidative damage in red blood cells?

León-Reyes, Guadalupe; Guzmán-Grenfell, Alberto Martı́n; Medina-Navarro, Rafael; Montoya-Estrada, Araceli; Moreno-Eutímio, Mario Adán; Fuentes-García, Silvia; Perera, Otilia Perichart; Muñoz-Manrique, Cinthya; Sosa, Salvador Espino Y; G, Juan José Hicks; Torres-Ramos, Yessica Dorín

doi:10.1080/09513590.2018.1473360

Cited by 5 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies from geographically and ethnically diverse populations have linked increased circulating AGEs and MDA to GDM. − In this study, we also observed the positive associations of AGEs and MDA with GDM. However, the results of the mediation analyses showed no significant mediation by AGEs and MDA on the association of 3-PBA and 4F-3PBA with the risk of GDM.…”

Section: Resultssupporting

confidence: 75%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

Pyrethroids, a class of extensively used insecticides, may pose health risks to humans. Whether pyrethroid exposure contributes to the development of gestational diabetes mellitus (GDM) in pregnant women remains unknown. The potential association of urinary concentrations of pyrethroid metabolites [3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid] with the risk of GDM was assessed using a nested case-control study of 220 GDM cases and 440 controls from a prospective cohort. The mediation roles of oxidative stress biomarkers [advanced glycation end products (AGEs) and malondialdehyde (MDA)] in the associations were investigated. Urinary concentrations of 3-PBA in these cases were significantly higher than those of the controls. Urinary 3-PBA was positively associated with the risk of GDM. The adjusted odds of GDM significantly increased by 32% in each unit increment of the ln-transformed concentration of urinary 3-PBA. The significant dose−response relationships of GDM with serum AGEs (P trend = 0.03) and MDA (P trend < 0.001) were observed. However, there were no significant correlations between 3-PBA and AGEs or MDA, nor was there a significant mediation effect of AGEs or MDA on the association of 3-PBA with GDM. We provide the first evidence that early gestational exposure to pyrethroids is an environmental risk factor for GDM.

show abstract

Section: Resultssupporting

confidence: 75%

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

Ma,

Song,

et al. 2024

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

show abstract

“… 17 Positive correlations between biomarkers of oxidative stress in RBC with GDM were discovered by previous study, suggesting the potential relationship between RBC and inflammatory response. 36 In addition, higher levels of RBC and HGB were accompanied with higher blood viscosity, which was reported to be a risk factor for insulin resistance. 37 The associations of RBC with insulin resistance and GDM need to be further confirmed.…”

Section: Discussionmentioning

confidence: 99%

The Association of Hematological Parameters in Early and Middle Pregnancy with the Risk of Gestational Diabetes Mellitus

Duo,

Song,

Qiao

et al. 2024

DMSO

View full text Add to dashboard Cite

Objective Gestational diabetes mellitus (GDM) is a condition of glucose intolerance, which may be accompanied with inflammation. The levels of hematological parameters during pregnancy can reflect inflammatory conditions in pregnant women. This study aims to describe the dynamic change of blood cell parameters from the first trimester (6–12 weeks of gestation) to the second trimester (24–28 weeks of gestation) and to investigate the associations of these biomarkers with the risk of GDM. Methods This study was a prospective double-center study conducted in Beijing, China (clinical trial number: NCT03246295). Hematological parameters were tested four times during the follow-up. Logistic regression analysis and Receiver Operating Characteristic (ROC) curve analysis were used to explore the association and predictive ability of hematological parameters for GDM. Results There were 258 of 1027 pregnant women in our study developed GDM. Among the 1027 pregnant women, white blood cells (WBC) gradually increased, and red blood cells (RBC), hemoglobin (HGB), and platelet (PLT) tended to decrease from the first trimester to second trimester. After adjusting for confounding factors, higher levels of RBC, HGB, and PLT in both early and middle pregnancy were positively associated with GDM risk, whereas the level of WBC was associated with GDM risk only in early pregnancy. WBC, RBC, HGB, and PLT in early and middle pregnancy were all correlated with fasting insulin (FINS) in early pregnancy. Conclusion Higher levels of hematological parameters in early and middle pregnancy were associated with glucose metabolism in early pregnancy and the subsequent risk of GDM.

show abstract

“…Clinical studies show increased lipid peroxidation (MDA, LOOH) [115][116][117][118][119] and significant changes in antioxidant status (total antioxidant capacity and antioxidant enzyme activity) in pregnant women with obesity [119][120][121][122][123] during the third trimester of pregnancy (Table 3). Another study has shown an increase in lipid peroxidation and protein carbonylation (PC) in pregnant women with obesity versus controls, only in the third trimester, but not in the first and second trimesters of pregnancy.…”

Section: Obesitymentioning

confidence: 99%

“…However, an increase in TNF-α was observed at 12-13 weeks of gestation, also in women with obesity who developed GDM. The ratio of reduced oxidized glutathione (GSH/GSSG) is an indirect marker of redox status [115]. In addition, increased antioxidant activity of SOD and CAT was observed in the placenta [122] and umbilical cord [119] of obese women compared to non-obese women, and compared to plasma activities during the third trimester of pregnancy.…”

Section: Obesitymentioning

confidence: 99%

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

Jiménez-Osorio,

Carreón-Torres,

Correa-Solís

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pregnancy. Therefore, an equilibrium between a necessary/pathologic level of inflammation and oxidative stress during pregnancy is needed to avoid disease development. High-density lipoproteins (HDL) are important for a healthy pregnancy and a good neonatal outcome. Their role in fetal development during challenging situations is vital for maintaining the equilibrium. However, in certain conditions, such as obesity, diabetes, and other cardiovascular diseases, it has been observed that HDL loses its protective properties, becoming dysfunctional. Bioactive compounds have been widely studied as mediators of inflammation and oxidative stress in different diseases, but their mechanisms of action are still unknown. Nonetheless, these agents, which are obtained from functional foods, increase the concentration of HDL, TRC, and antioxidant activity. Therefore, this review first summarizes several mechanisms of HDL participation in the equilibrium between inflammation and oxidative stress. Second, it gives an insight into how HDL may act as a vector for bioactive compounds. Third, it describes the relationships between the inflammation process in pregnancy and HDL activity. Consequently, different databases were used, including MEDLINE, PubMed, and Scopus, where scientific articles published in the English language up to 2023 were identified.

show abstract

Is gestational diabetes mellitus in obese women predicted by oxidative damage in red blood cells?

Cited by 5 publications

References 17 publications

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

First Evidence of the Associations of Exposure to Pyrethroid Insecticides with the Risk of Gestational Diabetes Mellitus

The Association of Hematological Parameters in Early and Middle Pregnancy with the Risk of Gestational Diabetes Mellitus

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

Contact Info

Product

Resources

About