Is Gnb3 C825t Polymorphism Associated With Elite Status of Polish Athletes?

Abstract

The GNB3 gene encodes the beta 3 subunit of heterotrimeric G-proteins that are key components of intracellular signal transduction between G protein-coupled receptors (GPCR) and intracellular effectors and might be considered as a potential candidate gene for physical performance.ObjectivesThe aim of this study was to compare frequency distribution of the common C to T polymorphism at position 825 (C825T) of the GNB3 gene between athletes and nonathletic controls of the Polish population as well as to compare the genotype distribution and allele frequency of C825T variants within a group of athletes, i.e. between athletes of sports of different metabolic demands and competitive levels.MethodsThe study was performed in a group of 223 Polish athletes of the highest nationally competitive standard (123 endurance-oriented athletes and 100 strength/ power athletes). Control samples were prepared from 354 unrelated, sedentary volunteers.ResultsThe χ2 test revealed no statistical differences between the endurance-oriented athletes and the control group or between sprint/strength athletes and the control group across the GNB3 825C/T genotypes. There were no male-female genotype or allele frequency differences in controls or in either strength/power or endurance-oriented athletes. No statistically significant differences in either allele frequencies or genotype distribution were noted between the top-elite, elite or sub-elite of endurance-oriented and strength/power athletes and the control group.ConclusionsNo association between elite status of Polish athletes and the GNB3 C825T polymorphic site has been found.

Does the GNB3 C825T Polymorphism Influence Swimming Performance in Competitive Swimmers?

“…Thus, we did not corroborate the findings of Eynon et al (2009) that the GNB3 TT genotype was more frequent in endurance-oriented athletes than in sprinters. However, we confirmed the observations of Ruiz et al (2011) and Sawczuk et al (2014) in which no correlation between the frequency of alleles and genotypes of the C825T polymorphism and athletic status was observed.…”

“…Research conducted on a group of top level Israeli athletes revealed a higher frequency of the genotype TT in elite endurance athletes in comparison to controls and athletes practicing strength-speed sports ( Eynon et al, 2009 ). However, the results of these observations have not been confirmed in subsequent research by Ruiz et al (2011) and Sawczuk et al (2014) .…”

Current Progress in Sports Genomics

“…However, when cohorts of athletes and controls from Israeli and Spanish populations were combined (155 Israeli and 153 Spanish athletes; 240 Israeli and 100 Spanish controls), no significant differences in genotypic and allelic frequencies between countries or groups were observed [97]. Furthermore, Sawczuk et al [98] could not confirm the prevalence of the T allele in 123 Polish endurance athletes in comparison with 354 sedentary volunteers.…”

Polymorphisms of catechol-O-methyltransferase ( COMT rs4680:G>A ) and μ-opioid receptor ( OPRM1 rs1799971:A >G ) in relation to pain perception in combat athletes

“…However, some genotypes were not confirmed as genetic markers of exercise performance in the Polish population [38], and further studies are needed.…”