Infrastructure, agglomeration, product and input markets, fiscal attributes, and labor markets of local communities influenced food manufacturing location decisions in the lower 48 United States, 2000-2004. Negative binomial regression and spatial clustering methods forecast food processor location patterns at the county level. Noncore counties are at a comparative disadvantage with respect to attracting most food processors, but nonmetropolitan counties adjacent to urban areas may be attractive investment sites for footloose, supply, and demand-oriented food manufacturers. Copyright (c) 2009 International Association of Agricultural Economists.