Is Gut Microbial LPS a Potential Trigger of Juvenile Idiopathic Arthritis?

Azzouz, Doua F.; Silverman, Gregg J.

doi:10.3899/jrheum.170791

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…We identified numerous autoimmune target antibodies to joint and bone sites that are correlated and elevated in subjects with elevated tight junction proteins (Figure 3 and Table 2). The integrity of the intestinal microbiota is found to be significantly different in patients with early rheumatoid arthritis [16,17]. Recent studies have suggested that intestinal permeability can lead to the circulation of arthritogenic bacteria and cause inflammation in synovial tissues [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

The Relationships between Intestinal Permeability and Target Antibodies for a Spectrum of Autoimmune Diseases

Kharrazian,

Herbert,

Lambert

2023

IJMS

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The worldwide prevalence of autoimmune diseases that have limited treatment options and preventive strategies is rapidly rising. There is growing evidence that the microbiota and the integrity of the intestinal barrier play a role in autoimmune diseases. The potential to evaluate intestinal barrier integrity for susceptible individuals and to determine whether restoring intestinal junction integrity impacts autoimmune diseases is an important area of research that requires further attention. In the intestinal permeability model of autoimmune diseases, the breakdown of the intestinal tight junction proteins (zonulin/occludin) allows bacteria, toxins, undigested dietary proteins, and other antigens to pass into the lumen, thereby increasing the number of inflammatory reactions and the activation of immune cells throughout the body. In this study, we investigate the relationship between zonulin/occludin antibodies, which are used to determine intestinal permeability, with autoantibodies used to diagnose autoimmunity. Our investigation may identify significant levels of circulating autoantibodies in human subjects with intestinal permeability compared to those without intestinal permeability. Furthermore, we identified that significant positive linear correlations between serum occludin/zonulin antibodies and circulating autoantibodies could be used to determine autoimmune diseases.

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