Is Healing of Fractures Regulated Centrally?

Clinical Efficacy of Injectable Platelet Rich Fibrin for the Treatment of TMJ Disc Displacement with Reduction

“…A rapid positive response in the "Responders" (90%) was observed as early as four to five days after the first injection and this percentage coincide with that of Khallaf et al's study which use PRP. [7] This suggests that PRF requires several days for its positive effects to occur and that can be explained by spontaneous clotting of liquid PRF (± 15 min), which preserves cells and growth factors in the articular space for a prolonged release [8] which coincides with albilia et al study who use i-PRF, however, responders in his study were 69% and this may be due to larger sample size. The slow release of growth factors from solid PRF matrices was demonstrated in vitro previously [9] There was a statistically significant difference between the repeated measures of pain score.…”