Is Helicobacter pylori infection a risk factor for idiopathic thrombocytopenic purpura in children?

Abdollahi, Alireza; Shoar, Saeed; Ghasemi, Shadi; Zohreh, Oloomi-Yazdi

doi:10.4103/1596-3519.153357

Cited by 12 publications

(17 citation statements)

References 3 publications

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“…Idiopathic thrombocytopenic purpura (ITP) is a well-known disease associated with H. pylori infection, even in terms of prevalence, as reported by Abdollahi et al 16 Hwang et al 17 showed a significant increase in the platelet counts in ITP patients after H. pylori eradication with H. pylori infection up to age 6.5 years had anemia more frequently (adjusted OR, 95% CI, 1.68; 1.22-2.32. P<.001).…”

Section: Hematologic Diseasesmentioning

confidence: 92%

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Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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During the past year, many articles were published on the extragastric diseases related to Helicobacter pylori infection. This supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. The role of H. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin B12 deficiency is well known. On the other hand, there is a growing interest in the bacterium's association with cardiovascular, neurologic, hematologic, dermatologic, head and neck, and uro-gynecologic diseases, as well as diabetes mellitus and metabolic syndrome, with very promising results. This review has been aimed at summarizing the results of the most relevant studies published over the last year on this fascinating topic.

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Section: Hematologic Diseasesmentioning

confidence: 92%

“…Idiopathic thrombocytopenic purpura (ITP) is a well‐known disease associated with H. pylori infection, even in terms of prevalence, as reported by Abdollahi et al . Hwang et al .…”

Section: Hematologic Diseasesmentioning

confidence: 98%

Helicobacter pylori and extragastric diseases

Goni

Franceschi

2016

Helicobacter

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“…Another option would be the blood antibody test (Abs), but due to the lack of specificity, this has been of little value. 27,28 First line treatment in ITP consists of the use of corticosteroids and rituximab, and for refractory patients, second line consists of immunosuppressive therapy (cyclosporine, cyclophosphamide or vincristine), or splenectomy. Laparoscopic splenectomy is preferred because of chronic steroid use, increased risk of infection, and problems with surgical site healing.…”

Section: 26mentioning

confidence: 99%

Splenectomy in non-traumatic diseases

Gomes¹,

Soares²,

Coccolini³

et al. 2018

AMJ

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Splenectomy represents the first choice for treatment of spontaneous splenic rupture, abscesses, cysts, tumours, and an alternative for control of hereditary, autoimmune, and myeloproliferative disorders. However, its relative indications have been reviewed for better understanding of both the primary affections and of splenectomy per se, particularly with regard to the immune system. The emergence of minimally invasive surgery, the possibility of splenic preservation, and availability of biological therapy has shown that the procedure has often been referred to as salvage therapy upon failure of other therapeutic propositions. On the other hand, patients have their general health status compromised by the underlying disease, by the use corticosteroids or biologic therapy, immunosuppressed, coagulation disorders, which contribute to the incidence of postoperative complications, such as infections, bleeding and venous thrombosis. Therefore, this scenario favours higher morbidity and mortality rates than those of other intra-abdominal surgical procedures. Thus, this review has the primary and comprehensive objective of purpose the best moment for splenectomy, when surgeons can interfere in the natural course of the disease increasing patients' quality of life and survival. In short, it is desired that the surgeon has complete knowledge of the profound physiological changes imposed on the host. In addition, to distinguish when it is curative and mandatory from when it must be put on hold due to other non-operative treatments with similar outcomes and, lastly, when it is not recommended for not aggregating survival. Key Words Splenectomy, splenomegaly, laparoscopyWhat this review adds: What is known about this subject?The indication of splenectomy in trauma patients is wellestablished; however in non-traumatic diseases it is much more controversial and current review and recommendations is scarce. What new information is offered in this review?This review explores the absolute and relative indications for splenectomy in different clinical sets. It also discourses on pathophysiological changes in an already compromised host. What are the implications for research, policy, or practice?Comprehensive review on the role of splenectomy in different non-traumatic settings, especially, haematological diseases in which it represents a rescue therapy because news biologic therapies.

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“…entitled “Is Helicobacter pylori infection a risk factor for idiopathic thrombocytopenic purpura (ITP) in children?” In the recent issue of Annals of African Medicine. [1] Regarding this article, some critical points are worth considering which are listed in below. ITP is an autoimmune disease identified by increased platelet destruction caused by antiplatelet autoantibodies.…”

mentioning

confidence: 99%

“…[1] It is now firmly established that in clinical trials concerning H. pylori and any kind of extradigestive disorders, we need to have adequate sample size.…”

mentioning

confidence: 99%