Is Helicobacter pylori infection associated with non-alcoholic fatty liver disease in individuals undergoing bariatric surgery? Cross-sectional study

Valadares, Erick Coelho; Gestic, Martinho Antônio; Gestic, Martinho Antonio; Chaim, Felipe David Mendonça; Chaim, Élinton Adami; Cazzo, Everton

doi:10.1590/1516-3180.2022.0517.r1.14122022

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…After excluding duplicates, we identified 34 potentially eligible studies from three large electronic databases from the inception to 30 November 2023. After examining the full text of these publications, we further excluded six observational studies, 25–30 because of unsatisfactory inclusion criteria or unsatisfactory outcome measures (Supplementary Table S1).…”

Section: Resultsmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Mantovani,

Lando,

Borella

et al. 2024

Liver International

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BackgroundRecent observational studies examining the association between Helicobacter pylori infection and the risk of metabolic dysfunction‐associated steatotic liver disease (MASLD) have reported conflicting results. We performed a meta‐analysis to quantify the magnitude of the association between H. pylori infection and the risk of MASLD.MethodsWe systematically searched three large electronic databases to identify eligible observational studies (published up to 30 November 2023) in which liver biopsy, imaging methods or blood‐based biomarkers/scores were used for diagnosing MASLD. Data from selected studies were extracted, and meta‐analysis was performed using common and random‐effects modelling. Statistical heterogeneity among published studies, subgroup analyses, meta‐regression analyses and publication bias were assessed.ResultsA total of 28 observational studies (24 cross‐sectional and 4 longitudinal studies) were identified, including 231 291 middle‐aged individuals of predominantly Asian ethnicity (~95%). Meta‐analysis of cross‐sectional studies showed that H. pylori infection was significantly associated with a small increase in the risk of prevalent MASLD (n = 24 studies; random‐effects odds ratio 1.11, 95% CI 1.05–1.18; I2 = 63%). Meta‐analysis of data from longitudinal studies showed that H. pylori infection was significantly associated with an increased risk of developing incident MASLD over a mean 5‐year follow‐up (n = 4 studies; random‐effects odds ratio 1.20, 95%CI 1.08–1.33; I2 = 44%). Sensitivity analyses did not modify these results. The funnel plot did not reveal any significant publication bias.ConclusionsH. pylori infection is associated with a mildly increased risk of prevalent and incident MASLD. Further well‐designed prospective and mechanistic studies are required to better decipher the complex link between H. pylori infection and the risk of MASLD.

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Section: Resultsmentioning

confidence: 99%

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Mantovani,

Lando,

Borella

et al. 2024

Liver International

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Is Helicobacter pylori infection a risk factor for non-alcoholic fatty liver disease in children?

Barakat,

Abdel-Fadeel,

Sharaki

et al. 2024

Eur J Pediatr

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Helicobacter pylori infection has been investigated as a potential risk factor for non-alcoholic fatty liver disease (NAFLD). Some studies suggest a possible link between the two conditions. The purpose of this study is to study the relationship between H. pylori infection and NAFLD in pediatrics and its relation to NAFLD grades. A case–control study to identify predictors of NAFLD and a comparative cross-sectional approach to determine factors affecting NAFLD grades were adopted. One hundred NAFLD children (ultrasound-based) and a control group of 100 non-NAFLD children were recruited. Both groups were evaluated by detecting H. pylori stool antigen. Immunoglobulin G antibodies to Cag A (cytotoxin-associated gene A), Vac A (vacuolating cytotoxin A), Gro EL (chaperonin Gro EL), HCPC (Helicobacter cysteine-rich protein C), and Ure A (Urease subunit A) were assessed in the serum of those with positive stool antigen. H. pylori infection was significantly higher in NAFLD children compared to the control group (64% versus 25%, p-value < .001). (NAFLD children showed higher Cag A and Vac A positivity (34, 10%) versus (2%, 0%) in the control group, respectively, p-value < .001). The regression model showed that H. pylori positivity (OR (odds ratio) = 5.021, 95% CI (confidence interval): 1.105–22.815), homeostatic model assessment of insulin resistance (Homa IR) (OR = 18.840, 95% CI: 3.998–88.789), waist percentile (OR = 1.184, 95% CI: 1.044–1.344), and triglycerides (OR = 1.029, 95% CI: 1.012–1.047) were predictors for NAFLD. Cag A positivity (OR = 2.740, 95% CI: 1.013–7.411) was associated with higher NAFLD grade (grade 2 fatty liver).Conclusions:H. pylori infection could increase the risk of NAFLD in children. Triglycerides, waist circumference, and Homa IR are significant independent predictors of NAFLD. What is Known: • NAFLD has become one of the most common liver diseases among children because of the increased prevalence of pediatric obesity.• Dyslipidemia and insulin resistance play a central role in NAFLD pathogenesis. • NAFLD could be explained by the multiple-hit hypothesis. The gut microbiota is an important factor in this hypothesis (gut liver axis). What is New: • Helicobacter pylori infection could increase the risk of NAFLD in children. • H. pylori Cytotoxin-associated gene A (Cag A) positivity is associated with higher NAFLD grade.

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Associations of Helicobacter pylori with metabolic dysfunction-associated steatotic liver disease and related conditions: cross-sectional results from the Hispanic Community Health Study/Study of Latinos

Alvarez,

Kaplan,

Camargo

et al. 2024

The Lancet Regional Health - Americas

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Is Helicobacter pylori infection associated with non-alcoholic fatty liver disease in individuals undergoing bariatric surgery? Cross-sectional study

Cited by 4 publications

References 23 publications

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Relationship between Helicobacter pylori infection and risk of metabolic dysfunction‐associated steatotic liver disease: An updated meta‐analysis

Is Helicobacter pylori infection a risk factor for non-alcoholic fatty liver disease in children?

Associations of Helicobacter pylori with metabolic dysfunction-associated steatotic liver disease and related conditions: cross-sectional results from the Hispanic Community Health Study/Study of Latinos

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