Is Heparinization Necessary in the Early Postoperative Period of Renal Transplantation from Cadaveric Donors?

Prophylactic antithrombotic management in adult and pediatric kidney transplantation: A systematic review and meta‐analysis

“…101 studies were excluded with reason (Table S3) leaving 12 studies (six pediatric and six adult studies) fulfilling the criteria for inclusion in the systematic review and meta-analysis. [8][9][10][11][26][27][28][29][30][31][32][33] No additional studies were found in available clinical trial registries, conference proceedings, and reference lists.…”

“…8,9 The clinical impact of aP for KTx recipients is still a matter of debate, primarily due to the paucity of available studies with partially conflicting results. [9][10][11] In the absence of evidence-based recommendations and consensus guidelines, current antithrombotic strategies are often characterized by incongruent, non-standardized, and center-specific protocols for aP. 12,13 Therefore, this systematic review and meta-analysis were performed to collate, summarize, and quantify the available evidence on beneficial and adverse effects of aP in adult and pediatric KTx recipients.…”

Prophylaxis with enoxaparin for prevention of venous thromboembolism after lung transplantation: a retrospective study

“…These studies showed inconsistent results for the balance between bleeding risk and thrombotic events. Heparin implies a significant increase in bleeding complications in both kidney and liver transplantation [28][29][30][31][32][33], but treatment with dalteparin adjusted for activated clotting time in liver transplantation seems to be safe [22]. Prophylaxis of renal or liver allograft thrombosis with aspirin alone seems to be another good option that does not increase the frequency of bleeding complications [17][18][19][20][21], although doses differ between studies.…”

“…In our study, we evaluated 90‐day extended prophylaxis with enoxaparin and found that this strategy did not protect against VTE. To our knowledge, this is the first study to evaluate a prophylaxis protocol in LT. Prophylaxis protocols have been evaluated in kidney and liver transplantation, although most studies were retrospective and analyzed few patients, and only two are randomized . These studies showed inconsistent results for the balance between bleeding risk and thrombotic events.…”

Evaluation of Heparin Anticoagulation Protocols in Post–Renal Transplant Recipients (EHAP-PoRT Study)

“…One small study suggested that prophylactic subcutaneous (SC) heparin therapy produces a non-statistically significant reduction in thromboembolic complications, 9 whereas other studies have suggested that prophylactic administration of heparin is not necessary in the early postoperative period for living-donor or deceased-donor renal transplant recipients with no other risk factors for VTE. 10,11 Despite the paucity of strong evidence for VTE prophylaxis following renal transplant, a prophylactic VTE heparin protocol was implemented institution-wide at St Paul's Hospital, Vancouver, British Columbia, in 2011. Before 2011, most renal transplant recipients at this institution received no postoperative anticoagulation unless there was an indication for therapeutic heparin.…”