Is High-Intensity Interval Training More Effective Than Moderate Continuous Training in Rehabilitation of Multiple Sclerosis: A Comprehensive Systematic Review and Meta-analysis

Youssef, Hussein; Gönül, Mine Nur; Sobeeh, Mohamed Gomaa; Akar, Kardelen; Feys, Peter; Cuypers, Koen; Vural, Atay

doi:10.1016/j.apmr.2023.12.012

Cited by 5 publications

(2 citation statements)

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“…In our study, this prescription did not affect adherence or neuromuscular performance. While the impact of this intervention on cognitive and cardiorespiratory parameters remains unknown, engaging MS patients in high-intensity interval exercise has been associated with greater increases in maximal oxygen consumption and cognitive capacity [31]. Future research should analyze the effect of circuit-based RT on this population, focusing on process and behavioral, cognitive, and cardiorespiratory variables.…”

Section: Discussionmentioning

confidence: 99%

“…Showing promise in enhancing muscle size and quality, augmenting muscle strength and power, boosting neural drive, improving functional ability and cognitive function, and reducing disease severity and self-reported fatigue in MS patients [22][23][24][25][26][27][28][29]. Furthermore, organizing the prescribed exercises in a circuit format may have significant effects on cardiorespiratory function and body composition [30], potentially surpassing those achieved with moderate-intensity aerobic exercise [31].…”

Section: Introductionmentioning

confidence: 99%

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Pumping up the Fight against Multiple Sclerosis: The Effects of High-Intensity Resistance Training on Functional Capacity, Muscle Mass, and Axonal Damage

Maroto-Izquierdo,

Mulero,

Menéndez

et al. 2024

Healthcare

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Background: Resistance training (RT) has been recognized as a beneficial non-pharmacological intervention for multiple sclerosis (MS) patients, but its impact on neurodegeneration is not fully understood. This study aimed to investigate the effects of high-intensity RT on muscle mass, strength, functional capacity, and axonal damage in MS patients. Methods: Eleven relapsing–remitting MS patients volunteered in this within-subject counterbalanced intervention study. Serum neurofilament light-chain (NfL) concentration, vastus lateralis thickness (VL), timed up-and-go test (TUG), sit-to-stand test (60STS), and maximal voluntary isometric contraction (MVIC) were measured before and after intervention. Participants performed 18 sessions of high-intensity RT (70–80% 1-RM) over 6 weeks. Results: Significant (p < 0.05) differences were observed post-intervention for VL (ES = 2.15), TUG (ES = 1.98), 60STS (ES = 1.70), MVIC (ES = 1.78), and NfL (ES = 1.43). Although moderate correlations between changes in VL (R = 0.434), TUG (R = −0.536), and MVIC (R = 0.477) and changes in NfL were observed, only the correlation between VL and MVIC changes was significant (R = 0.684, p = 0.029). Conclusions: A 6-week RT program significantly increased muscle mass, functional capacity, and neuromuscular function while also decreasing serum NfL in MS patients. These results suggest the effectiveness of RT as a non-pharmacological approach to mitigate neurodegeneration while improving functional capacity in MS patients.

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Section: Discussionmentioning

confidence: 99%