Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study

Snijder, Marieke B.; Heijden, Amber A. W. A. van der; Dam, Rob M. van; Stehouwer, Coen D. A.; Hiddink, G.J.; Nijpels, Giel; Heine, Robert J.; Bouter, L.M.; Dekker, Joost

doi:10.1093/ajcn/85.4.989

Cited by 137 publications

(136 citation statements)

References 43 publications

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“…Likewise, in the Coronary Artery Risk Development in Young Adults study, Pereira et al [8] found that among individuals (aged 18-30 years) who were overweight at baseline, dairy consumption was inversely associated with the incidence of obesity, abnormal glucose homeostasis, dyslipidemia, and hypertension over the next 10 years. In contrast, findings from the Hoorn cohort found that higher dairy product intake was significantly associated with higher fasting glucose concentrations and lower diastolic BP, but not with body weight or other metabolic variables (ie, lipids, postload glucose, or insulin [36]. In the latter study, when different dairy products were distinguished, significant inverse associations were observed for dairy desserts, milk, and yogurt with systolic and diastolic BP, whereas cheese consumption was positively associated with BMI.…”

Section: Discussionmentioning

confidence: 60%

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Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents

Abreu

Moreira

et al. 2014

Nutrition Research

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Epidemiologic studies have reported an inverse association between dairy product consumption and cardiometabolic risk factors in adults, but this relation is relatively unexplored in adolescents. We hypothesized that a higher dairy product intake is associated with lower cardiometabolic risk factor clustering in adolescents. To test this hypothesis, a cross-sectional study was conducted with 494 adolescents aged 15 to 18 years from the Azorean Archipelago, Portugal. We measured fasting glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body fat, and cardiorespiratory fitness. We also calculated homeostatic model assessment and total cholesterol/high-density lipoprotein cholesterol ratio. For each one of these variables, a z score was computed using age and sex. A cardiometabolic risk score (CMRS) was constructed by summing up the z scores of all individual risk factors. High risk was considered to exist when an individual had at least 1 SD from this score. Diet was evaluated using a food frequency questionnaire, and the intake of total dairy (included milk, yogurt, and cheese), milk, yogurt, and cheese was categorized as low (equal to or below the median of the total sample) or "appropriate" (above the median of the total sample).The association between dairy product intake and CMRS was evaluated using separate logistic regression, and the results were adjusted for confounders. Adolescents with high milk intake had lower CMRS, compared with those with low intake (10.6% vs 18.1%, P = .018). Adolescents with appropriate milk intake were less likely to have high CMRS than those with low milk intake (odds ratio, 0.531; 95% confidence interval, 0.302-0.931). No association was found between CMRS and total dairy, yogurt, and cheese intake. Only milk intake seems to be inversely related to CMRS in adolescents.

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Section: Discussionmentioning

confidence: 60%

“…On the other hand, the preponderance of evidence, mostly in adults, indicates that milk intake is more likely to be associated with beneficial cardiometabolic outcomes [13], [39], [40] and [41]. Few studies have shown the beneficial effects of other dairy products [10], [36] and [42].…”

Section: Discussionmentioning

confidence: 99%

Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents

Abreu

Moreira

et al. 2014

Nutrition Research

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“…In addition, the magnitude of blood pressure reduction was of greater magnitude after the diet rich in low-fat dairy products compared with the fruit and vegetable-rich diet, which omitted dairy products altogether (119) . The findings from cross-sectional and prospective observational studies have shown an inverse association between consumption of dairy products, particularly low-fat varieties, and risk of hypertension (64,65,(120)(121)(122)(123)(124)(125)(126) . The recent results from the Framingham Heart Study Offspring Cohort (n 2636) also showed benefit from low/reduced fat dairy products (127) .…”

Section: Dairy Proteins and Blood Lipidsmentioning

confidence: 99%

Dairy food products: good or bad for cardiometabolic disease?

Lovegrove

Givens

2016

Nutr. Res. Rev.

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Prevalence of type 2 diabetes mellitus (T2DM) is rapidly increasingly and is a key risk for CVD development, now recognised as the leading cause of death globally. Dietary strategies to reduce CVD development include reduction of saturated fat intake. Milk and dairy products are the largest contributors to dietary saturated fats in the UK and reduced consumption is often recommended as a strategy for risk reduction. However, overall evidence from prospective cohort studies does not confirm a detrimental association between dairy product consumption and CVD risk. The present review critically evaluates the current evidence on the association between milk and dairy products and risk of CVD, T2DM and the metabolic syndrome (collectively, cardiometabolic disease). The effects of total and individual dairy foods on cardiometabolic risk factors and new information on the effects of the food matrix on reducing fat digestion are also reviewed. It is concluded that a policy to lower SFA intake by reducing dairy food consumption to reduce cardiometabolic disease risk is likely to have limited or possibly negative effects. There remain many uncertainties, including differential effects of different dairy products and those of differing fat content. Focused and suitably designed and powered studies are needed to provide clearer evidence not only of the mechanisms involved, but how they may be beneficially influenced during milk production and processing.

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“…Epidemiologic studies have supported the hypothesis that a dairy-rich diet is associated with lower fat accumulation, although prospective and intervention studies are not unanimous [1][2][3][4][5][6]. Our understanding of the mechanisms responsible for this association remains incomplete.…”

Section: Introductionmentioning

confidence: 99%

Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

Chen¹,

Reimer²

2009

Nutrition

143

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Objective-A growing body of evidence supports an antiobesity effect of dairy products; however, the mechanisms remain unclear. The objective of this study was to explore possible intestinal mechanisms by which dairy delivers an antiobesity effect. The human intestinal cell line, NCI-H716, was used to test the hypothesis that branched-chain amino acids and dairy proteins regulate satiety hormone secretion and modulate genes involved in fatty acid and cholesterol metabolism.Methods-In dose-response (0.5%, 1.0%, 2.0%, and 3.0%) studies, the effect of leucine, isoleucine, valine, skim milk, casein, and whey on glucagon-like peptide-1 release and the expression of selected genes were tested.Results-Leucine, isoleucine, skim milk, and casein stimulated glucagon-like peptide-1 release (P < 0.05). Isoleucine and whey downregulated the expression of intestinal-type fatty acid binding protein (i-FABP), fatty acid transport protein 4 (FATP4), Niemann-Pick C-1-like-1 protein (NPC1L1), acetyl-coenzyme A carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element-binding protein-2 (SREBP-2), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR; P < 0.05). Leucine and valine downregulated the expression of NPC1L1, ACC, FAS, SREBP-2, and HMGCR (P < 0.05). Casein downregulated the expression of i-FABP, FATP4, ACC, FAS, SREBP-2, and HMGCR (P < 0.05). Skim milk downregulated the expression of ACC, FAS, and SREBP-2, but not i-FABP, FATP4, and NPC1L1.Conclusion-This work suggests that the antiobesity effect of dairy may be mediated, at least in part, by integration of events that promote glucagon-like peptide-1 secretion and inhibit expression of genes involved in intestinal fatty acid and cholesterol absorption and synthesis.

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Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study

Cited by 137 publications

References 43 publications

Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents

Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents

Dairy food products: good or bad for cardiometabolic disease?

Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro

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