Is Histaminase Identical with Diamine Oxidase?

Kapeller-Adler, Regine

doi:10.1002/9780470718957.ch41

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…It has been discussed for a long time whether histaminase and diamine oxidase are one or two enzymes (see Zeller, 1956;Kapeller-Adler, 1956). The work here presented leads us to suggest that the histaminase of pig kidney, a classical source for the study of this enzyme, is in fact a diamine oxidase, as was first proposed by Zeller.…”

Section: Distribution Of Plasma Amine Oxidases and Classification Of mentioning

confidence: 99%

The amine oxidases of mammalian plasma

Blaschko¹,

Friedman²,

Hawes³

et al. 1959

The Journal of Physiology

111

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The amine oxidases are enzymes which are of importance in the biological inactivation of amines naturally occurring in the animal body. They catalyse the oxidative deamination of a terminal amino group, free or substituted. The classification of these enzymes, which are widely distributed in animal tissues, is based on work carried out twenty years ago, when it was shown that there existed an enzyme called amine oxidase (or monoamine oxidase) which acts not only on adrenaline, tyramine and tryptamine, but also on many aliphatic monoamines, and a second enzyme called histaminase (or diamine oxidase) which is responsible for the oxidation of histamine and the aliphatic diamines, e.g. putrescine or cadaverine. A convenient source for the study of histaminase is the pig's kidney; the liver and many other mammalian tissues have served as a source of amine oxidase. It has since been shown that longchain aliphatic diamines are substrates of amine oxidase and not of the pigkidney histaminase. This work has been reviewed some time ago (Blaschko, 1952; see also Zeller, 1951).Little is known about the mechanisms of electron transfer in reactions catalysed by amine oxidases. The so-called 'mono' amine oxidase is not inhibited by cyanide, semicarbazide or carbonyl reagents, substances which are all potent inhibitors of histaminase.A few years ago an enzyme was found in the blood plasma of the sheep and the ox (Hirsch, 1953;Tabor, Tabor & Rosenthal, 1954) which is characterized by its high activity with spermine or spermidine as substrates. This enzyme is inhibited by inhibitors of histaminase, but it also acts on a number of monoamines which are typical substrates of amine oxidase. Thus this enzyme resembles amine oxidase in its substrate specificity but histaminase in its inhibitor specificity.The present studies of the amine oxidase of mammalian plasma arose from some observations on the oxidation of the anti-malarial compound, Primaquin * Present address: Institute of Physiology, University of Lund.

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Section: Distribution Of Plasma Amine Oxidases and Classification Of mentioning

confidence: 99%

The amine oxidases of mammalian plasma

Blaschko¹,

Friedman²,

Hawes³

et al. 1959

The Journal of Physiology

111

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“…Voge suggested that estimation of histidine in urine may serve as a chemical test for pregnancy. This suggestion has been strongly supported mainly by Kapeller-Adler and her co-workers (Kapeller-Adler, 1933, 1936Hermann, 1934, 1936;Kapeller-Adler and Hass, 1935 ;Kapeller-Adler and Schiller, 1935). These authors claim that the urine of men and non-pregnant women is, except occasionally, free of histidine, that histidinuria begins soon after the embedding of the ovum, persists throughout normal pregnancy and that it ceases only after parturition or after the expulsion of the dead ovum (Kapeller-Adler, 1950).…”

mentioning

confidence: 91%

Histidine Excretion in Normal and Abnormal Pregnancy

Gabrawy¹,

Kamal²

1954

BJOG

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“…Histamine exists in practically every cell of the human body but a cell is considered a producer of histamine only if it has histidine decarboxylase (Kapeller-Adler, 1956;Schwartz, 1977).…”

Section: Introductionmentioning

confidence: 99%

“…In the central nervous system (CNS) histamine may be produced in mastocytes, glial cells, and histaminergic neurons (Kapeller-Adler, 1956;Blanco et a!., 1987).…”

Section: Introductionmentioning

confidence: 99%

Decrease in blood histamine in drug-treated Parkinsonian patients

Coelho¹,

Silva²,

Azevedo³

et al. 1991

Molecular and Chemical Neuropathology

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Blood histamine and serum histaminase activity were determined in a group of patients with Parkinson disease (PD) and in a group of healthy controls. Untreated PD patients present significantly higher blood histamine than normal controls. Therapy with L-dopa + cardidopa results in a significant decrease in blood histamine. This decrease becomes more accentuated when anticholinergics are added to this therapy. No significant changes were detected in plasma histaminase. The authors suggest, as a hypothesis, that the CNS contributes to blood histamine concentration and that its rise is the result of increased neuronal destruction.

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Is Histaminase Identical with Diamine Oxidase?

Cited by 8 publications

References 15 publications

The amine oxidases of mammalian plasma

The amine oxidases of mammalian plasma

Histidine Excretion in Normal and Abnormal Pregnancy

Decrease in blood histamine in drug-treated Parkinsonian patients

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