Is hyperpolarised gas magnetic resonance imaging a valid and reliable tool to detect lung health in cystic fibrosis patients? a cosmin systematic review

Mallallah, Fatmah; Packham, Anna; Lee, Ellen; Hind, Daniel

doi:10.1016/j.jcf.2020.12.020

Cited by 3 publications

(3 citation statements)

References 44 publications

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“…Patient-reported outcome measures, such as the St George's Respiratory Questionnaire or Leicester Cough Questionnaire, may provide insight into the longer term outcomes of ACT regimens [ 87 ]. Biomarkers, such as the percentage of ventilation defects within the lungs identified by hyperpolarised gas ventilation magnetic resonance imaging [ 89 , 90 ], have the potential to detect changes in lung health [ 87 , 91 ]. As more sensitive quantitative outcome measures, biomarkers could be used along with patient-important outcomes, such as exacerbation frequency, quality of life and patient preference, in evaluating the effectiveness of care personalisation.…”

Section: Discussionmentioning

confidence: 99%

Personalising airway clearance in chronic suppurative lung diseases: a scoping review

et al. 2023

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BackgroundPersonalised airway clearance techniques are commonly recommended to augment mucus clearance in chronic suppurative lung diseases. It is unclear what current literature tells us about how airway clearance regimens should be personalised. This scoping review explores current research on airway clearance technique in chronic suppurative lung diseases, to establish the extent and type of guidance in this area, identify knowledge gaps and determine the factors which physiotherapists should consider when personalising airway clearance regimens.MethodsSystematic searching of online databases (MEDLINE, EMBASE, CINAHL, PEDro, Cochrane, Web of Science) was used to identify full-text publications in the last 25 years that described methods of personalising airway clearance techniques in chronic suppurative lung diseases. Items from the TIDieR framework provideda prioricategories which were modified based on the initial data to develop a “Best-fit” framework for data charting. The findings were subsequently transformed into a personalisation model.ResultsA broad range of publications were identified, most commonly general review papers (44%). The items identified were grouped into seven personalisation factors: physical, psychosocial, ACT type, procedures, dosage, response, and provider. As only two divergent models of airway clearance technique personalisation were found, the personalisation factors identified were then used to develop a model for physiotherapists.ConclusionsThe personalisation of airway clearance regimens is widely discussed amongst current literature which provides a range of factors that should be considered. This review summarises the current literature, organising findings into a proposed airway clearance personalisation model, to provide clarity in this field.

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Section: Discussionmentioning

confidence: 99%

Personalising airway clearance in chronic suppurative lung diseases: a scoping review

et al. 2023

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“…Numerous studies have consistently shown that this new imaging technique holds promise as a valuable tool for early detection and longitudinal monitoring of CF progression. For instance, a study conducted by Mallallah et al (14) highlighted the high sensitivity of HP MRI in comparison to the forced expiratory volume in 1 second (FEV1) modality for detecting CF structural and functional ventilation defects, as well as monitoring the response to treatment. HP MRI overcomes the limitations associated with low proton density in standard MRI.…”

Section: Medical Technologymentioning

confidence: 99%

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

MOKBEL,

KODRESKO,

GHAZAL

et al. 2023

In Vivo

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This paper explores the crucial role of cryogenic mediums in driving breakthroughs within the biomedical sector. The objective was to investigate, critically discuss, and present the current knowledge and state-of-the-art practices, along with the challenges and perspectives of the most common applications. Through an extensive literature review, this work aims to supplement existing research, offering a comprehensive and up-to-date understanding of the subject. Biomedical research involving cryogenic mediums is advancing on multiple fronts, including the development of advanced medical technologies, clinical treatments for life-threatening conditions, high-quality biospecimen preservation, and antimicrobial interventions in industrial food processing. These advances open new horizons and present cutting-edge opportunities for research and the medical community. While the current body of evidence showcases the impressive impact of cryogenic mediums, such as nitrogen, helium, argon, and oxygen, on

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“…Multiple studies in recent years have shown HP gas MRI to be safe, accurate and reproducible, with the ability to detect early-stage CF lung disease and to monitor response to therapeutic interventions [5 ▪▪ ,28 ▪▪ ,36 ▪ ]. The first multisite trial of HP Xe-129 MRI in CF found strong correlation with LCI and moderate correlation with FEV 1 [5 ▪▪ ,36 ▪ ,37 ▪▪ ]. More multisite studies are anticipated in the near future.…”

Section: Reviewmentioning

confidence: 99%

The evolving role of radiological imaging in cystic fibrosis

Crowley¹,

Connor²,

Ciet³

et al. 2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewRadiological imaging has a crucial role in pulmonary evaluation in cystic fibrosis (CF), having been shown to be more sensitive than pulmonary function testing at detecting structural lung changes. The present review summarizes the latest published information on established and evolving pulmonary imaging techniques for assessing people with this potentially life-limiting disorder. Recent findingsChest computed tomography (CT) has taken over the predominant role of chest radiography in many centres for the initial assessment and surveillance of CF lung disease. However, several emerging techniques offer a promising means of pulmonary imaging using less ionizing radiation. This is of particular importance given these patients tend to require repeated imaging throughout their lives from a young age. Such techniques include ultra-low-dose CT, tomosynthesis, dynamic radiography and magnetic resonance imaging. In addition, deep-learning algorithms are anticipated to improve diagnostic accuracy.

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Is hyperpolarised gas magnetic resonance imaging a valid and reliable tool to detect lung health in cystic fibrosis patients? a cosmin systematic review

Cited by 3 publications

References 44 publications

Personalising airway clearance in chronic suppurative lung diseases: a scoping review

Personalising airway clearance in chronic suppurative lung diseases: a scoping review

Cryogenic Media in Biomedical Applications: Current Advances, Challenges, and Future Perspectives

The evolving role of radiological imaging in cystic fibrosis

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