Is hyperthermic intraperitoneal chemotherapy (HIPEC) safe for healthcare workers?

Rodier, Simon; Saint-Lorant, Guillaume; Guilloit, Jean-Marc; Palix, Agnès; Divanon, Fabienne; Sichel, François; Delépée, Raphaël

doi:10.1016/j.suronc.2017.04.001

Cited by 11 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The different published results showed inconsistent contamination with platinum compounds, which could be explained by the limit of quantification of the analysis implemented. Even if this study shows blood contamination with two different antineoplastic drugs assessed in two different laboratories, further studies should be performed in other surgeons, other operating theater caregivers, other centers and different antineoplastic drugs used during HIPEC such as mitomycine C to confirm these results considering the inconsistent contamination found in the literature [27]. Toxicological studies have also to be led to assess effects at the concentration of AD found.…”

Section: Discussionmentioning

confidence: 69%

“…Of the nine published biomonitoring studies carried out in HIPEC, six are based on urine samples with the limitations of urine samples previously mentioned [27]. For these six studies, the results are quantifiable in two studies.…”

Section: Discussionmentioning

confidence: 99%

“…This could help future studies focus on understanding healthcare workers' blood contamination risk; however this will not directly prevent contamination. To complete this blood contamination assessment, we can also perform surface samples to look for the source of contamination both in the operating room and ward environment even if it does not prejudge the systematic passage to exposed healthcare professionals [27]. Furthermore, from these videos, simulation training sessions could be developed to improve the surgeons' practice during surgery concerning safety.…”

Section: Discussionmentioning

confidence: 99%

“…There are mainly two different biological pathways to validate healthcare workers' contamination: urine and blood. Regarding using urine, there are different limitations: the metabolites' stability, different volume, urine dilution and variable hydration levels of the surgeons from whom the urine is collected may not be suitable [26,27]. Platinum compounds have been detected in blood samples of different healthcare workers [28].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?

Saint-Lorant

Rodier

Guilloit

et al. 2021

Pleura and Peritoneum

Self Cite

View full text Add to dashboard Cite

Objectives Hyperthermic intraperitoneal chemotherapy (HIPEC) is a beneficial surgical technique for patients, but the surgeons are being exposed to cytotoxic drugs. Few biomonitoring studies were led on blood samples in the context of HIPEC. This study aimed to evaluate the surgeon’s plasmatic and red blood cell (RBC) contamination by irinotecan, two of its major metabolites and platinum compounds. Methods HIPEC procedures performed using the coliseum techniques were observed between September 2015 and April 2018 in a French comprehensive cancer center. Irinotecan and its metabolites SN-38 and APC were dosed by UHPLC with a limit of quantification determined at 50 pg/mL. Platinum compounds were dosed by inductively coupled plasma mass spectrometry with a limit of quantification determined at 16 pg/mL. Results Despite collective and personal protective equipment, 80% of plasma samples were contaminated by irinotecan and 33% by platinum compounds out of 21. The results showed that the surgeon was contaminated after HIPEC and even after a period of HIPEC inactivity. Nineteen percent of plasmatic samples and 45% of RBC samples were contaminated by SN-38, the active metabolite of irinotecan. APC was only found in some RBC samples (33%). Conclusions Even if this study shows blood contamination by irinotecan, two of its major metabolites (including active SN-38) and platinum compounds both in the plasma and RBC of a surgeon performing the HIPEC procedures, further studies should be performed to confirm these results. Additional studies should be carried out to further investigate the contamination in the context of HIPEC and more broadly in the hospital.

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?

Saint-Lorant

Rodier

Guilloit

et al. 2021

Pleura and Peritoneum

Self Cite

View full text Add to dashboard Cite

show abstract

“…Educação e capacitação da equipe envolvida na HIPEC Todos estudos abordam a importância da capacitação da equipe envolvida no procedimento, não somente dos que assistem o paciente no intraoperatório, mas também dos profissionais que higienizam a sala cirúrgica após o procedimento, Riboli GB, Santos CB, Gomes NA, Araújo BR, Sakamoto VT, Caregnato RC recolhem resíduos, realizam desinfecção dos instrumentais cirúrgicos e farmacêuticos que manipulam quimioterápicos. (2,3,12,13,(22)(23)(24)(25)(26)(27) Dos dez estudos analisados, seis ressaltam a importância de abordar com a equipe não somente técnica cirúrgica, mas o desfecho esperado; medicamentos utilizados e indicação; via de administração; riscos associados ao procedimento, como minimizar exposição; e manejo de derramamentos e contato com o medicamento. (2,3,12,(25)(26)(27) Outro estudo (25) traz a capacitação regular da equipe para revisão de processos e rotinas, disponibilização de manual com indicação de cada agente antineoplásico na sala cirúrgica e cuidados na manipulação.…”

Section: Discussionunclassified

Medidas de segurança ocupacional no transoperatório de quimioterapia hipertérmica intraperitoneal: scoping review

Riboli¹,

Santos²,

Gomes³

et al. 2022

Acta Paulista De Enfermagem

View full text Add to dashboard Cite

Conflitos de interesse: nada a declarar. ResumoObjetivo: Mapear as medidas de segurança ocupacional recomendadas aos profissionais envolvidos no atendimento transoperatório de pacientes submetidos à Quimioterapia Intraperitoneal Hipertérmica.Métodos: Estudo qualitativo com ênfase em scoping review, fundamentado no Instituto Joanna Briggs. Realizou-se buscas nas bases de dados Pubmed, BVS, ScIELO, Scopus, Web of Science, Google Scholar, The Chocrane Library e literatura cinzenta. Pergunta de pesquisa utilizou o acrônimo PCC: quais medidas de segurança ocupacional são necessárias no Centro Cirúrgico para profissionais que atuam, direta ou indiretamente, no transoperatório da HIPEC? A Busca de artigos ocorreu entre 2015 a 2019.Resultados: Evidenciou-se escassa literatura sobre a temática. Selecionados dez artigos: uma revisão sistemática; dois casos-controle; dois estudos descritivos; quatro estudos de revisão bibliográfica; um relato de experiência. Análise dos artigos evidenciou as medidas de segurança recomendadas para profissionais que atuam direta ou indiretamente nesse procedimento cirúrgico, a saber: educação e capacitação da equipe envolvida; utilização de equipamentos de proteção individual e coletiva; oferecer infraestrutura e orientações gerais.Conclusão: Medidas de segurança recomendadas para os profissionais envolvidos no atendimento transoperatório do paciente submetido à Quimioterapia Intraperitoneal Hipertérmica são: capacitação da equipe; utilização de equipamentos específicos de proteção individual e coletiva; infraestrutura necessária como ajuste do ar condicionado com pressão maior dentro da sala cirúrgica; e orientações gerais em relação à organização da sala cirúrgica, descarte dos resíduos, limpeza da sala/materiais utilizados e acompanhamento da saúde ocupacional da equipe envolvida em procedimento cirúrgico.

show abstract

Clinical Issues — January 2024

Cahn

2023

AORN Journal

View full text Add to dashboard Cite

THIS MONTH Off‐label medication use and prescribing practices Key words: off‐label, licensed prescriber, approved, unapproved, US Food and Drug Administration (FDA). Prophylactic, therapeutic, and empiric use of antimicrobial agents Key words: prophylactic, therapeutic, empiric, infection, antimicrobial. Perioperative RN administration of antineoplastic agents Key words: antineoplastic medication, chemotherapy, hyperthermic intraperitoneal chemotherapy (HIPEC), instillation device, perfusionist. Minimum efficiency reporting values, parameters, and testing for air filters in heating, ventilation, and air‐conditioning systems Key words: heating, ventilation, and air‐conditioning (HVAC); minimum efficiency reporting value (MERV); particle size removal efficiency; air filter; filtration.

show abstract

Is hyperthermic intraperitoneal chemotherapy (HIPEC) safe for healthcare workers?

Cited by 11 publications

References 43 publications

Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?

Is the blood of a surgeon performing HIPEC contaminated by irinotecan, its major metabolites and platinum compounds?

Medidas de segurança ocupacional no transoperatório de quimioterapia hipertérmica intraperitoneal: scoping review

Clinical Issues — January 2024

Contact Info

Product

Resources

About