Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies

Abstract

BackgroundHyperuricemia has been reported to be associated with chronic kidney disease (CKD). However whether an elevated serum uric acid level is an independent risk factor for new-onset CKD remained controversial.MethodsA systematic review and meta-analysis using a literature search of online databases including PubMed, Embase, Ovid and ISI Web/Web of Science was conducted. Summary adjusted odds ratios with corresponding 95% confidence intervals (95% CI) were calculated to evaluate the risk estimates of hyperuricemia for new-onset CKD.ResultsThirteen studies containing 190,718 participants were included. A significant positive association was found between elevated serum uric acid levels and new-onset CKD at follow-up (summary OR, 1.15; 95% CI, 1.05–1.25). Hyperuricemia was found be an independent predictor for the development of newly diagnosed CKD in non-CKD patients (summary OR, 2.35; 95% CI, 1.59–3.46). This association increased with increasing length of follow-up. No significant differences were found for risk estimates of the associations between elevated serum uric acid levels and developing CKD between males and females.ConclusionsWith long-term follow-up of non-CKD individuals, elevated serum uric acid levels showed an increased risk for the development of chronic renal dysfunction.

Cost-effectiveness Analysis for Genotyping before Allopurinol Treatment to Prevent Severe Cutaneous Adverse Drug Reactions

“…Hyperuricemia is prevalent in patients with CKD 40 . It is recommended that allopurinol therapy be started with a low dose and close monitoring in these patients, but the reduction in risk of allopurinol-related SCAR was not significant 41,42 .…”

Linking uric acid metabolism to diabetic complications

“…SUA is also associated with known risk factors for kidney disease progression [52] , including hypertension [53] , cardiovascular disease [54][55][56] , and atherosclerosis [55] . SUA is an independent risk factor for CKD, even without diabetes [57] . SUA is known to be associated with disease progression in the early stage of diabetic nephropathy [17,58] .…”

Relation of Hyperuricaemia, Renal Function and Arterial Hypertension in a Large Region of the Eastern Siberia Inhabitants

“…В самом деле, целый ряд исследований продемон-стрировал, что ГУ может задолго предшествовать развитию как гипертонии, так и метаболического синдрома, а также ХБП, что трудно объяснить с пози-ций вторичности изменений со стороны пуринового обмена [1,3,4].…”

“…Показан, в том числе и на основании мета-анализов, повышенный риск развития при ГУ ИБС, сердечной недостаточности, инсультов, фибрилляции предсердий, ХБП, увеличе-ния кардиоваскулярной летальности [1,2,4].…”