Is <i>Helicobacter Pylori</i> infection inversely associated with atopy? A systematic review and meta‐analysis

Taye, Bineyam; Enquselassie, Fikre; Tsegaye, Aster; Medhin, Girmay; Davey, Gail; Venn, Andrea

doi:10.1111/cea.12404

Cited by 40 publications

(37 citation statements)

References 47 publications

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“…33 Recent meta-analysis suggests that colonization by HP might protect against the development of certain autoimmune disorders, such as asthma 8,34 and atopic dermatitis. 9 Particularly, Helicobacter pylori infection on acute gastrointestinal GvHD A Velasco-Guardado et al HP neutrophil-activating protein has been shown to act as an immune-modulating agent to suppress Th2 responses in ovalbumin-induced allergic asthma and Trichinella spiralis infection. 35,36 We should emphasize the negative association that has been established in several studies between inflammatory bowel disease and HP infection with a significant relative risk (RR) lower than 1 in a recent meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…7 Chronic HP infection has also been related to several nongastrointestinal diseases. 8,9 Because of its ability to elicit a chronic immune response in the host, studies have suggested a possible role for HP in the development of autoimmune diseases. 10 HP can produce endoscopic findings similar to those caused by gastrointestinal GvHD (GI-GvHD), and histological analysis may reveal apoptotic bodies.…”

Section: Introductionmentioning

confidence: 99%

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Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD

Velasco-Guardado

Mora-Soler

López-Corral

et al. 2016

Bone Marrow Transplant

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Previous reports ascribe a modulating capacity of the immune response to Helicobacter pylori (HP). Our hypothesis was to demonstrate in a prospective study that HP infection could have a protective effect against development of gastrointestinal GvHD in patients receiving allogeneic hematopoietic cell transplantation (HCT). Presence of HP before transplant was determined using C 13 urea breath test. Seventy-nine patients receiving an allogeneic HCT were included and 93.7% of them received PBSC; in 51.9%, the donor was unrelated. Acute gastrointestinal GvHD was diagnosed in 51.9% (n = 41). In the multivariable analysis, HP infection was associated with a lower frequency of gastrointestinal GvHD (odds ratio (OR) = 0.19 (95% confidence interval (CI): 0.05-0.67); in contrast, an unrelated donor was associated with a higher frequency of gastrointestinal GvHD (odds ratio = 5.4 (95% confidence interval: 1.6-18.2). One year overall survival (OS) was 74%. In the multivariate Cox proportional-hazards regression analysis, stages 0-II gastrointestinal GvHD (hazards ratio (HR) = 0.19), reduced intensity conditioning (HR = 0.04) and tacrolimus-sirolimus GvHD prophylaxis (HR = 0.06) were all associated with a better OS. In summary, HP infection could have a role in decreasing gastrointestinal GvHD in patients receiving allogeneic HCT from peripheral blood including related and unrelated donors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD

Velasco-Guardado

Mora-Soler

López-Corral

et al. 2016

Bone Marrow Transplant

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“…11,12 H. pylori infection reduces the development of atopy by approximately 20%, which is protective against IgE mediated reactions. 13 No association between EE with FMF has previously been reported. However, Gurkan OE et al 14 reported a case of esophagitis and widespread aphthous ulcerations in gastric mucosa in an infant with FMF.…”

Section: T H I S S T U D Y D E S C R I B E S ( I ) T H E C L I N I C mentioning

confidence: 98%

Esophageal eosinophilia in children: A 6-year single-center experience

et al. 2017

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“…Negative HPI associations have been reported with several allergic diseases including atopy, asthma and allergic rhinitis [70][71][72] . Evidence from epidemiological studies suggested HPI accounted for an estimated 18 % reduction in odds of atopy [70] .…”

Section: Immune Responsementioning

confidence: 99%

“…Evidence from epidemiological studies suggested HPI accounted for an estimated 18 % reduction in odds of atopy [70] . Sheptulin et al suggested a negative HPI association in bronchial asthma and chronic inflammatory intestinal diseases [71] .…”

Section: Immune Responsementioning

confidence: 99%

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

2017

Med One

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Helicobacter pylori (H. pylori) infection (HPI) is one of the most widespread diseases. More than half of world population is affected by HPI, especially children in developing countries. The associations between many gastrointestinal diseases and HPI have been found in clinical. Also, there are some diseases whose HPI associations are controversial and unclear. Due to its unclear disease association, H. pylori test is not included in the clinical screening. However, some pre-clinical studies showed possible associations between HPI and these diseases, involving pathological changes of different functional systems of the human body (e.g., Immune system, cerebrovascular system). Therefore, for HPI patients, more attention should be paid to the possible risks of these diseases. In this study, a systematic literature review was conducted to identify and classify H. pylori related diseases. This review identified 175 HPI related diseases belonging to 9 categories, and summarized the corresponding supporting literature reports. In addition, the functional mechanisms underlying the linkages between HPI and 28 well studied diseases were discussed, revealing possible pathogenesis for these diseases. We conclude that HPI is related to many serious diseases affecting multiple important human systems, and clinical HPI treatment and HPI test might help the detection and treatment of these diseases. Our results guarantee further study using more data to testify the possible relations between HPI and these diseases.

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Is Helicobacter Pylori infection inversely associated with atopy? A systematic review and meta‐analysis

Cited by 40 publications

References 47 publications

Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD

Potential protective effect of Helicobacter pylori on the development of gastrointestinal GvHD

Esophageal eosinophilia in children: A 6-year single-center experience

Helicobacter Pylori Infection Associated Diseases – A Systematic Review

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