Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?

Šimac, Daniel Victor; Štimac, Tea; Novak, Srđan

doi:10.1007/s11882-022-01040-3

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…bradykinin B-2 receptor antagonist, SC icatibant Firazyr There is mixed data. International guideline notes that there are reports of safe administration in pregnancy [6,13]. However, a review article states that it cannot be recommended due to need for more evidence [9].…”

Section: Example Datamentioning

confidence: 99%

Successful Pregnancy Outcome in a Hereditary Angioedema Patient With Previous Pregnancy Losses: A Proposed Delivery Plan

Satnarine,

Xavier de Almeida,

Gebbia

et al. 2024

Cureus

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This case report underscores the effective implementation of a delivery plan for a pregnant patient, focusing on a successful case study where a cesarean section, preceded by the pre-treatment of intravenous plasma-derived C1 inhibitor, resulted in the delivery of a healthy baby. The proposed delivery plan offers a systematic approach to managing hereditary angioedema during pregnancy. It recommends opting for delivery at an academic center equipped with high-risk obstetric care, obstetric anesthesia, and a level 4 Neonatal Intensive Care Unit. The plan also emphasizes the importance of early admission at the onset of labor and delineates specific protocols for both vaginal and cesarean deliveries.

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Section: Example Datamentioning

confidence: 99%

Successful Pregnancy Outcome in a Hereditary Angioedema Patient With Previous Pregnancy Losses: A Proposed Delivery Plan

Satnarine,

Xavier de Almeida,

Gebbia

et al. 2024

Cureus

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“…Tranexamic acid should not be used for on-demand therapy given the risk of thrombotic/embolic events in addition to a lack of studies regarding its use in pregnant and/or lactating HAE patients [58]. Multiple case reports suggest icatibant as a safe choice for rescue therapy during pregnancy without any reportable adverse effects or abnormalities, but we believe the data are far too shallow to make this recommendation [68][69][70][71][72].…”

Section: Recommendationsmentioning

confidence: 99%

Preferred Therapy for Patients with Hereditary Angioedema during Pregnancy

Park,

Yeich,

Craig

2023

Future Pharmacology

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Hereditary angioedema (HAE) is a rare, inherited disease caused by a deficiency (HAE-1) or lack of functional (HAE-2) C1 inhibitor protein. The symptoms present with mucocutaneous swelling of various organ systems, such as the respiratory and gastrointestinal systems, which can manifest as stridor and abdominal pain, respectively. HAE can present with increased frequency and severity of attacks during the pregnancy and lactation period. This is thought to be due to hormonal changes, which may trigger HAE attacks. The management of this condition in pregnant and lactating patients can be challenging for providers due to disease rarity and the lack of data regarding the management of this specific population. This review aims to provide insights for HAE management regarding rescue therapy, short-term prophylaxis, and long-term prophylaxis via the consolidation of the current literature and various international consensus guidelines. Furthermore, this review discusses when to initiate treatment and at what frequency and dosing, as well as the possible side effects that may occur as a result of therapy.

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Epinephrine/icatibant/oxytocin

2022

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Is Icatibant Safe for the Treatment of Hereditary Angioedema During Pregnancy?

Cited by 5 publications

References 10 publications

Successful Pregnancy Outcome in a Hereditary Angioedema Patient With Previous Pregnancy Losses: A Proposed Delivery Plan

Successful Pregnancy Outcome in a Hereditary Angioedema Patient With Previous Pregnancy Losses: A Proposed Delivery Plan

Preferred Therapy for Patients with Hereditary Angioedema during Pregnancy

Epinephrine/icatibant/oxytocin

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