Is in vitro maturation of oocytes retrieved ex vivo from ovarian tissue an effective fertility preservation technique in the presence of organic ovarian cysts?

Bourg, Mona; Moreau, Jessika; Carles, Manon; Cadoret, Florence; Lesourd, Florence; Tournier, A.; Léandri, Roger; Gatimel, Nicolas

doi:10.1016/j.ejogrb.2022.12.025

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Segers et al reported that immature oocytes could not be collected in one patient with BOT among 34 patients who underwent OTO-IVM, including 32 cases with extra-ovarian diseases [ 12 ]. Boung et al also conducted OTO-IVM in 10 cases with or without ovarian tumors, and reported that only 1.5 (mean) immature oocytes were retrieved when ovarian tumors were present, but 14 immature oocytes when tumors were absent [ 13 ]. Therefore, we consider that we were able to obtain a large number of oocytes.…”

Section: Discussionmentioning

confidence: 99%

Successful pregnancy using immature oocytes retrieved from resected borderline ovarian tumor: a case report and literature review

Higuchi,

Miyamoto,

Oka

et al. 2024

Contracept Reprod Med

View full text Add to dashboard Cite

Background Despite the recent progress of fertility preservation technique, achievement of pregnancy in women with ovarian tumor is still challenging. Here, we report a case of OTO-IVM (ovarian tissue oocyte in-vitro maturation) resulting in a successful delivery. Case presentation The patient, a 33-year-old woman with a history of left borderline ovarian tumor (BOT) who underwent left salpingo-oophorectomy three years ago, presented with an enlarged right ovary during infertility treatment, indicating the recurrence of BOT. Because the patient disagreed with curative surgery and normal part-preservation surgery, we eventually performed OTO-IVM. A right salpingo-oophorectomy was first performed. Eight immature oocytes were immediately aspirated not only from visible follicles, but also from entire cortex for invisible follicles, of the removed ovary. In addition, IVM procedure generated six mature oocytes, and were subjected to intracytoplasmic sperm injection (ICSI). Accordingly, three embryos were obtained and cryopreserved. Three months after surgery, hormone replacement therapy was initiated, and a frozen-thawed embryo was transferred, resulting in a successful pregnancy. Although a cesarean section was performed at 36 weeks due to maternal ileus, the baby was delivered without complications. Conclusions This report indicates this treatment to be an effective approach for fertility preservation in BOT patients, especially, the importance of collecting oocytes from the entire ovarian cortex was suggested.

show abstract

Section: Discussionmentioning

confidence: 99%