Is Infantile Colic a Migraine-Related Phenomenon?

Jan, Mohammed M.; Al-Buhairi, Amira R.

doi:10.1177/000992280104000512

Cited by 40 publications

(44 citation statements)

References 10 publications

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“…19,20 The underlying pathogenesis of colic is not well understood, despite much research. 9,13 The term "colic" implies an abdominal derivation for the infants' distress, although no clear evidence for that localization exists. Some have implicated excessive intestinal gas 21 or a problem with the infant's milk.…”

Section: Discussionmentioning

confidence: 99%

“…The research to date linking infant colic to migraine is primarily retrospective in nature, 9,10 making it subject to recall bias. The goal of this study was to assess whether a maternal history of migraine predicts colic in young infants.…”

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confidence: 99%

“…9,10 This study minimized recall bias by collecting data on colic prevalence during the period of infancy when colic occurs. The magnitude of the association between colic and maternal migraine in this study is consistent with what has been described previously.…”

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confidence: 99%

“…In a small retrospective study by Jan and Al-Buhairi, 9 52% of the children with migraine had a history of colic vs 20% of control children. Because our study uses maternal history of migraine as a means for inferring possible familial migraine tendency in the infants, it is notable that in the study of Jan and Al-Buhairi, 9 a history of infant colic in a first-degree relative was more likely in the migraineur children, and those children with a history of colic were more likely to have a family history of migraine. 9 In the second study, a history of colic was also more likely in children with migraine than in headache-free control children (38.4% vs 26.9%) or in children with tension-type headache (38.4% vs 25.2%).…”

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Before the headache

2012

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Objective: Childhood periodic syndromes are thought to be early life expressions of the genetic tendency for migraine. The objective of this study was to determine whether maternal migraine is associated with an increased risk of infant colic, because this may indicate that colic is a childhood periodic syndrome.Methods: This was a cross-sectional study performed in general pediatric clinics. To minimize recall bias, mothers were surveyed at their infants' 2-month-old well-child visit, the age when colic is most prevalent. Colic was ascertained via parental report using modified Wessel criteria. Migraine history was obtained by having a physician diagnosis or a positive screen on ID Migraine. The primary outcome measure was difference in colic prevalence in infants with and without a maternal history of migraine. Results:Data from 154 infant-mother pairs were analyzed. Infants with a maternal history of migraine were 2.6 times as likely to have colic as infants without a maternal history of migraine (29% vs 11%, prevalence ratio 2.6 (95% confidence interval 1.2Ϫ5.5), p ϭ 0.02). There was no difference in the accuracy with which migraineur mothers perceived their infants' colic status compared with that of nonmigraineur mothers. Data on paternal history of migraine were available for 93 infants. Infants with a paternal history of migraine may have a higher prevalence of colic (22% vs 10%), although the prevalence ratio 2.3 (0.6Ϫ9.4, p ϭ 0.24) had wide confidence intervals. Conclusions:Maternal migraine is associated with increased risk of infant colic. Because migraine has a strong genetic underpinning, this association suggests that colic may be an early life manifestation of migraine. Neurology

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Before the headache

2012

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“…23–25 In a cross-sectional study, mothers with migraine were more than twice as likely to have an infant with colic. 26 In a meta-analysis study, odds of migraine were increased five to six-fold if there was a history of infant colic (OR 5.6 (95% CI 3.3–9.5)).…”

Section: The Case For Infant Colic As a Migrainous Phenomenonmentioning

confidence: 99%

Infant Colic

Gelfand

2016

Seminars in Pediatric Neurology

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This article reviews the evidence for an association between infant colic and migraine. Infant colic, or excessive crying in an otherwise healthy and well-fed infant, affects approximately 5–19% of infants. Multiple case-control studies, a cross-sectional study, and a prospective cohort study have all found an association between infant colic and migraine. While infant colic is often assumed to have a gastrointestinal cause, several treatment trials aimed at gastrointestinal etiologies have been negative. Teaching parents how best to respond to inconsolable crying may be helpful and important for preventing shaken baby syndrome. Given accumulating evidence for a connection between infant colic and pediatric migraine, future studies should examine migraine-oriented treatments for infant colic. Infant colic should be moved into the main body of International Classification of Headache Disorders (ICHD-III beta) as one of the “Episodic syndromes that may be associated with migraine”.

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