Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues

Thrailkill, Kathryn M.; Lumpkin, Charles K.; Bunn, R. Clay; Kemp, Stephen F.; Fowlkes, John L.

doi:10.1152/ajpendo.00159.2005

Cited by 441 publications

(385 citation statements)

References 143 publications

(117 reference statements)

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“…The beneficial roles of insulin on skeletal health has been entertained by many authors [1], supported by the observations that lower BMD in type 1 diabetes [2,3] and higher BMD in subjects with type 2 diabetes [4,5]. We found that there are stronger associations of BMAD with fasting insulin and insulin AUC in AA adolescents.…”

Section: Discussionsupporting

confidence: 85%

Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents

Ashraf

Alvarez

Huisingh

et al. 2013

BJMMR

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BackgroundPuberty is a developmental stage of increased insulin resistance that also is a critical period for bone mass accrual. Historically, African Americans (AA) have lesser risk for osteoporotic fractures compared to European Americans (EA). AA also have higher incidence of insulin resistance. The possibility that bone health and insulin secretion or concentrations are linked has not been investigated.AimsWe aimed to examine the associations of bone mineral density (BMD) and bone mineral apparent density (BMAD) with insulin sensitivity and secretion in healthy adolescent girls and healthy female adults and to evaluate ethnic differences in these associations.Study DesignObservational cohort design.Place and Duration of the StudyUniversity of Alabama at Birmingham, between January 2010 and September 2011.MethodologyHealthy, female, non-smoking adolescents and young adults (14–55 years) were enrolled in this observational cohort study.ResultsAdolescents had significantly higher fasting insulin (P=0.0002), insulin area under the curve [AUC] (P= 0.0004) and lower insulin sensitivity (P=0.0005) compared to adults. Among adolescents, AA race was significantly associated with BMD (β=0.086, P=0.01) and BMAD (β=0.0075, P=0.002); however, adjusting for insulin AUC explained this difference. Insulin AUC (β=0.0006, P=0.029) and fasting insulin (β=0.0005, P=0.01) were positively associated with BMAD only in AA adolescents. Insulin AUC and fasting insulin were not significant predictors of BMD for adults.ConclusionThe higher insulin concentration among AA adolescents is associated with increased BMD and higher BMAD.

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Section: Discussionsupporting

confidence: 85%

Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents

Ashraf

Alvarez

Huisingh

et al. 2013

BJMMR

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“…Hyperglycemia leads to osteopenia and impairment of wound healing, which is intimately associated with unbalance between the production and the metabolism of reactive oxygen species (ROS) 3 . Also, hyperglycemia can increase the inflammatory response and the osteoclastic activity, which can compromise the bone neoformation during bone repair 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Aqueous-ozone irrigation of bone monocortical wounds in hyperglycemic rats

Frascino

Mantesso²,

Corrêa³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To analyze the effects of aqueous ozone irrigation over bone healing in hyperglycemia-induced rats. METHODS:Forty-eight male Wistar rats were allocated into Group H (hyperglycemic) or Group N (control). Monocortical bone wound were performed on femurs' anterolateral face. Wounds were treated with a trans-operatory single irrigation of 100ml of aqueous ozone [0.004mg/ml] whereas control groups received 100ml of pure water (Milli-Q ® ). Histomorphological and histomorphometrical analyses were accomplished after seven, 14 and 21 days. Kruskal-Wallis and Mann-Whitney statistical tests were applied for bone neoformation quantification and assessment. RESULTS:Aqueous ozone wounds irrigated revealed diffuse hemorrhage and increased neoformed of blood vessels number. There was no statistical significant difference in bone trabeculae neoformation. After seven and 14 days, the number of osteoclasts was higher in aqueous ozone groups than in those treated with pure water. CONCLUSION:Independently of blood glucose levels, aqueous ozone allowed an increase in blood vessels neoformation and osteoclast migration, without affect bone trabeculae neoformation.

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“…Resorption events have been linked to numerous factors other than cytokines and hormones, such as growth factors and reactive oxygen species (ROS) formation either in the bone microenvironment or in the osteoclastic precursors of the monocyte-macrophage lineage (Bai et al, 2004;Thrailkill et al, 2005b). Over the last decade, evidence has accumulated of ROS participation in bone resorption, with a direct contribution of osteoclasts generating high concentrations of superoxide anion (O2-) and hydrogen peroxide (H2O2) (Muthusami et al, 2005;Bai et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

Duarte

Rodrigues

Rezende

et al. 2010

Braz. J. Pharm. Sci.

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The relationship between lipid peroxidation, antioxidant defense and diabetic osteopenia remains unclear. This study evaluated the relationship among lipid peroxidation index, antioxidant defense parameters and bone metabolism in a premenopausal diabetic model using measures including thiobarbituric acidreactive substances concentration (TBARS) and reduced glutathione (GSH) content in brain homogenates, histomorphometric analysis, biomechanical testing and bone mineral density (BMD). Female Wistar rats with regular estrous cycle were divided into two groups: Group 1: control rats (n = 15) and Group 2: diabetic rats (n = 15). Diabetes was induced by alloxan and confirmed by glycemia ≥250 mg/dL. The lipid peroxidation index, measured by TBARS concentration, showed a significant increase (p<0.05) in diabetic animals in comparison to control animals. However, the antioxidant parameter measured by GSH content, was significantly lower (p<0.05) in diabetic animals. Histomorphometric analysis showed a significant increase (p<0.05) in femoral trabecular separation together with a significant decrease (p<0.05) in trabecular thickness, and reduced trabecular bone volume in diabetic rats. Moreover, biomechanical testing and BMD values were significantly lower (p<0.05) in the diabetic group. Thus, our results demonstrated that increased lipid peroxidation and altered antioxidant defense could be related to the development of oxidative stress and diabetic osteopenia in premenopausal rats.Uniterms: Oxidative stress. Lipid peroxidation. Diabetes mellitus. Diabetic osteopenia/experimental study.A relação entre peroxidação lipídica, defesa antioxidante e osteopenia diabética permanece obscura. Este estudo avaliou a associação entre índice de peroxidação lipídica, parâmetro de defesa antioxidante e metabolismo ósseo em um modelo diabético pré-menopausa através de medidas como a concentração de substâncias reativas ao ácido tiobarbitúrico (SRAT) e conteúdo de glutationa reduzida (GSH) no homogenato cerebral, análises histomorfométricas, teste biomecânico e densidade mineral óssea (DMO). Ratos Wistar fêmeas com ciclo estral regular foram distribuídos em dois grupos: Grupo 1 -ratas controle (n = 15) e Grupo 2 -ratas diabéticas (n = 15). O diabetes foi induzido pela aloxana e confirmado pela glicemia ≥250 mg/dL. O índice de peroxidação lipídica, medido pela concentração de SRAT, demonstrou um aumento significativo (p<0.05) nos animais diabéticos, em relação aos animais controle. Entretanto, o parâmetro de defesa antioxidante, mensurado pelo conteúdo de GSH, foi reduzido significativamente (p<0.05) nos animais diabéticos. As análises histomorfométricas mostraram um aumento significativo (p<0.05) da separação trabecular do fêmur, associado à diminuição significativa da espessura trabecular (p<0.05) e volume ósseo trabecular reduzido nas ratas diabéticas. Além disso, o teste biomecânico, V.M.G. Duarte, A. de S. Rodrigues, L.A. de Rezende, A.Ma. de O. Ramos, R.M. de Souza, F.P.F. Neto, A. da C. Medeiros 540 medido pela força máxima, e val...

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Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues

Cited by 441 publications

References 143 publications

Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents

Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents

Aqueous-ozone irrigation of bone monocortical wounds in hyperglycemic rats

Relationship between oxidative stress and diabetic osteopenia in premenopausal rats

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