Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up

Abstract

Background Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes. Methods Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery. Results The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days. Conclusion This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results.

Is the Combination of Platelet-Rich Plasma and Hyaluronic Acid the Best Injective Treatment for Grade II-III Knee Osteoarthritis? A Prospective Study

“…For almost half a century, HA has been one of the most used injective drugs for the treatment of osteoarthritis considering both its physical-chemical properties and its interaction with cartilages' cells and extracellular matrixes (ECMs) [17]. In the last decades, the continuous search for the discovery of new and efective injective treatments has driven the interest in regenerative biologic therapies [18]. Autologous platelet-rich plasma (PRP) has been introduced as an alternative to HA for cases sufering from moderate knee osteoarthritis, leading to encouraging results in terms of both pain relief and functional recovery [19,20].…”

Mesenchymal stem cells can improve discogenic pain in patients with intervertebral disc degeneration: a systematic review and meta-analysis

“…MFAT as a tissue graft can liberate MSCs for a considerable period of time and its injection application can reduce pain and may promote tissue regeneration and repair (Vezzani et al, 2018;Nava et al, 2019). Relevant studies have demonstrated that intraarticular injection of MFAT has yielded beneficial clinical results, but its use in discogenic pain is still in the preliminary stages of exploration (Ferracini et al, 2022;Natali et al, 2022). The ADSCs were not included in our study, which may be subject to cell source bias.…”

The Efficacy of Anterior Cruciate Ligament Reconstruction with Peroneus Longus Tendon and its Impact on Ankle Joint Function

“…This follow‐up protocol was maintained until February 2023. Magnetic resonance examination performed 1 year postoperatively to confirm tendon healing condition, anterior drawer test, Lachman test, pivot shift test performed, IKDC score, 10 Knee Injury and Osteoarthritis Outcome Score (KOOS) score, 11 Lysholm score 12 used to evaluate affected side knee joint function, AOFAS score 13 used to evaluate donor area ankle joint function. The Opti Knee three‐dimensional motion measurement and analysis system‐Yidong Medical Infrared Motion Gait Analyzer (Shanghai Yidong Medical Technology Co. Shanghai, China) was used for bilateral knee joint and ankle joint analysis collection.…”