2005
DOI: 10.1016/j.urology.2005.06.073
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Is intraoperative frozen section analysis an efficient way to reduce positive surgical margins?

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Cited by 61 publications
(35 citation statements)
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“…Despite advances in technique, surgery for prostate cancer remains fraught with positive surgical margins (PSM) due to the inability to detect early extra capsular extension intra-operatively (2). Efforts to decrease PSM by the use of numerous technical maneuvers during the procedure have been disappointing, suggesting that new techniques are needed to prevent residual malignant tissue at the time of surgery, when it can still be removed (3). The proximity of the neurovascular bundles and rectum to the prostate precludes routine wide excision during radical prostatectomy, and efforts to spare the neurovascular bundles (and preserve penile erectile function) results in PSM in 10–38% of men at high volume centers, with particularly high rates in men with the most dangerous and aggressive disease (2, 4).…”
Section: Introductionmentioning
confidence: 99%
“…Despite advances in technique, surgery for prostate cancer remains fraught with positive surgical margins (PSM) due to the inability to detect early extra capsular extension intra-operatively (2). Efforts to decrease PSM by the use of numerous technical maneuvers during the procedure have been disappointing, suggesting that new techniques are needed to prevent residual malignant tissue at the time of surgery, when it can still be removed (3). The proximity of the neurovascular bundles and rectum to the prostate precludes routine wide excision during radical prostatectomy, and efforts to spare the neurovascular bundles (and preserve penile erectile function) results in PSM in 10–38% of men at high volume centers, with particularly high rates in men with the most dangerous and aggressive disease (2, 4).…”
Section: Introductionmentioning
confidence: 99%
“…At the time of surgery, all gross disease was resected en bloc with the prostate and seminal vesicles; subsequently, frozen sections were sent to pathology of the remaining bladder neck. Though previous researchers have commented on obtaining frozen sections from the apex (13,14) and posterolateral (15,16) regions, we have found that quite difficult in the presence of a true anatomic RP, since only minuscule tissue may be available at these sites for sampling. However, there is adequate tissue to sample at the bladder neck to ensure a negative margin at this location.…”
Section: Commentsmentioning
confidence: 70%
“…One has to keep in mind that an intraoperative fresh frozen section is not always accurate. In a recent study Tsuboi et al [5] report only 42% sensitivity in identifying positive resection margins on a fresh frozen section in radical prostatectomy specimens. Sensitivity might even further decrease in rare tumor entities such as sarcoma.…”
Section: Discussionmentioning
confidence: 99%