Is it all in our genes? The “mite-y” truth

Hershey, Gurjit K. Khurana

doi:10.1016/j.jaci.2004.01.564

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…The heterogeneity of the clinical phenotypes in asthma and respiratory allergy shows the complexity of this type of diseases, and this reflects the involvement of genetic and environmental factors, and therefore, its multifactorial character. Many investigations have aimed to identify the environmental risk factors and genes associated with these diseases (1). Faced with such great complexity, new techniques such as massive analysis or omics have become important tools in efforts to advance existing knowledge of the diagnosis, follow-up, and treatment-monitoring of asthmatic, and allergic diseases, and also in the search for risk-related or protective biomarkers and the development of new drugs (2).…”

Section: Introductionmentioning

confidence: 99%

Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity

et al. 2019

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Asthma is a complex disease comprising various phenotypes and endotypes, all of which still need solid biomarkers for accurate classification. In a previous study, we defined specific genes related to asthma and respiratory allergy by studying the expression of 94 genes in a population composed of 4 groups of subjects: healthy control, nonallergic asthmatic, asthmatic allergic, and nonasthmatic allergic patients. An analysis of differential gene expression between controls and patients revealed a set of statistically relevant genes mainly associated with disease severity, i.e., CHI3L1, IL-8, IL-10, MSR1, PHLDA1, PI3 , and SERPINB2 . Here, we analyzed whether these genes and their proteins could be potential asthma biomarkers to distinguish between nonallergic asthmatic and asthmatic allergic subjects. Protein quantification was determined by ELISA (in serum) or Western blot (in protein extracted from peripheral blood mononuclear cells or PBMCs). Statistical analyses were performed by unpaired t -test using the Graph-Pad program. The sensitivity and specificity of the gene and protein expression of several candidate biomarkers in differentiating the two groups (and the severity subgroups) was performed by receiver operating characteristic (ROC) curve analysis using the R program. The ROC curve analysis determined single genes with good sensitivity and specificity for discriminating some of the phenotypes. However, interesting combinations of two or three protein biomarkers were found to distinguish the asthma disease and disease severity between the different phenotypes of this pathology using reproducible techniques in easy-to-obtain samples. Gene and protein panels formed by single biomarkers and biomarker combinations have been defined in easily obtainable samples and by standardized techniques. These panels could be useful for characterizing phenotypes of asthma, specifically when differentiating asthma severity.

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Section: Introductionmentioning

confidence: 99%

Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity

et al. 2019

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“…However, there are some essential points that are well established by scientific community, as to recognize that few genes might have independent effects, as is typical for Mendelian diseases. It has become clear that the pathogenesis of complex polygenic disorders is dependent on multilayered geneenvironment interactions over time, in a model well described by Hersey (2004). Nonetheless, the approaches that have been used to find susceptibility genes, either through linkage or association studies, have for the most part considered one gene at a time.…”

Section: Genetic and Genomic Studies In Allergymentioning

confidence: 99%

New Challenges for Old Diseases: The Impact of -Omics Technologies in the Understanding of Allergic Diseases

Cárdaba¹,

Aguerri²,

Calzada³

et al. 2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…Düz olarak "yersiz, olağan dışı" anlamlarındadır. İlk kez 1923 yılında Coca ile Cooke, bu sözcüğü çevresel alerjenlere karşı kendini astım veya saman nezlesi ile gösteren kalıtsal bir hipersensitivite için kullanmıştır (3)(4)(5). Günümüzde ise sık karşılaşılan çevresel alerjenlere karşı erken hipersensitivite reaksiyonları geliştirmeye kalıtsal bir yatkınlık için kullanılmaktadır (1,6 Ev tozu akarlarının yakını olan uyuz böceği ile ilgili bilgiler, varsayımımıza arka çıkmaktadır.…”

Section: Introductionunclassified

Diagnosis of “Atopic Dermatitis”

Karaman¹,

Aksungur²

2016

tdd

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Dermatit, derinin incitici etmenleri savmaya uğraşmasıdır. Çevresel alerjenlere karşı immünglobulin E'ye (IgE) bağlı hipersensitivite reaksiyonları geliştirmeye kalıtsal yatkınlık anlamında "atopi" teriminin kullanılmaya başlanması daha bir yüzyıl olmamıştır. IgE'nin ana işlevinin asalaklara karşı savunma olduğu göz önünde tutulursa, atopinin de evrimsel olarak başta asalaklar olmak üzere, inciticileri savmak amacıyla gelişmiş bir özellik olabileceği ileri sürülebilir. "Atopik dermatit" teriminin kullanılması daha da yenidir. Atopik dermatit, tüm yaş dönemlerindeki kişilerde gelişebilir. Tüm deri bölgelerini etkileyebilir. Bir bölgede kısıtlı da olabilir, tüm deriye yayılmış da olabilir. Sulanma, kepeklenme ile kalınlaşma biçimlerinde kendini gösterebilir. Atopik dermatit için birçok tanısal ölçüt tanımlanmıştır. Bunlar, çok sayıda ölçüt içerir. Bu nedenle günlük uygulamada kullanılmaları kolay değildir. Bu bilgilerin ışığında, atopik dermatit tanısı koymaya uğraşmak yerine, tüm egzamalı olgularda atopi varlığını/yokluğunu değerlendirmek daha uygundur. Daha önemlisi, egzamayı tetikleyen incitici etmenleri belirlemeye çalışmaktır. Anahtar kelimeler: Atopi, atopik dermatit, hipersensitivite, IgE, alerjen Bilge FettahlıoğluKaraman, Varol Lütfü Aksungur "Atopik Dermatit" Tanısı Diagnosis of "Atopic Dermatitis" Öz AbstractDermatitis is an effort of the skin to get over injuring agents. The use of the term "atopy" in the meaning of an inherited predisposition to develop immunglobulin E (IgE) dependent hypersensitivity reactions against to environmental allergens is not yet a century old. If one keeps in mind that the main function of IgE is to defend the host against to parasites, one may suggest that atopy is a feature, which has been evolutionarily gained to get over injuring agents, particularly parasites. The use of the term "atopic dermatitis" is even newer. Atopic dermatitis may occur at all age groups, may involve all regions of the skin, may be either localized to a particular region or generalized to the whole skin, and may be characterized by oozing, scaling and/or thickening of the skin. Many sets of diagnostic criteria have been proposed for atopic dermatitis. These are composed of numerous criteria. Therefore, their use is not easy in the daily practice. In the light of these informations, evaluation or absence of atopy in all cases with eczema is a more suitable approach than to make a diagnosis of "atopic dermatitis". It is more important to identify the injuring agents, which have triggered eczema.

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Is it all in our genes? The “mite-y” truth

Cited by 5 publications

References 25 publications

Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity

Discriminatory Molecular Biomarkers of Allergic and Nonallergic Asthma and Its Severity

New Challenges for Old Diseases: The Impact of -Omics Technologies in the Understanding of Allergic Diseases

Diagnosis of “Atopic Dermatitis”

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