Is it really safe to replace decabromodiphenyl ether (<scp>BDE209</scp>) with decabromodiphenyl ethane (<scp>DBDPE</scp>)?: A perspective from hepatotoxicity

Wang, Yanting; Yang, Yu‐Shun; Dang, Chenyuan; Lü, Bin; Luo, Yin; Fu, Jie

doi:10.1002/tox.23727

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…The European research project ENFIRO highlights alternatives like zinc stannate, zinc borate, aluminum diethylphosphinate, and melamine polyphosphate for their improved safety and flame retardant properties . However, the applicability and safety of NBFRs remain uncertain due to limited studies on their ecological risk. ,− Therefore, consistent and thorough monitoring of NBFRs throughout their life cycle is imperative to managing their emissions and environmental risks. More data on their bioaccumulation, metabolism, and toxicity are needed to understand their long-term effects.…”

Section: Resultsmentioning

confidence: 99%

Brominated Flame Retardants (BFRs) in China Over the Past Half-Century: Stocks, Flows, Fates, and Ecological Risks

Chen,

Ma,

Liu

et al. 2024

Environ. Sci. Technol.

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China is a significant producer and consumer of various brominated flame retardants (BFRs), raising environmental concerns due to their widespread presence and potential threats to ecosystems and organisms. This study adopts a life cycle perspective, combining material flow analysis, multimedia environmental modeling, and ecological risk assessment to systematically analyze the substance metabolism and ecological risks of six BFR types in China from 1970 to 2021. The findings reveal that China's cumulative BFR consumption reached 3.3 Mt, with the electronics sector being the predominant contributor at 52.1%. Consequently, 1.5 kt of BFRs were released into the environment, with 24.9%, 31.5%, and 43.6% being discharged into the air, water, and soil, respectively. Notably, the proportion of novel BFRs in emissions has steadily increased over the years, exemplified by the increase in decabromodiphenyl ethane (DBDPE) from 21.3% in 2010 to 30.1% in 2021. Geographically, BFR concentrations are higher in the eastern and southwestern regions compared to those in the northwest. Presently, certain BFRs like tetrabromobisphenol A (TBBPA) and DBDPE exhibit moderate to high ecological risks, primarily concentrated in the Shandong and Sichuan provinces. A combination of efficient recycling, emission control, and substitution with novel flame-retardant can minimize the exposure of BFRs to the environment and organisms.

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Section: Resultsmentioning

confidence: 99%

Brominated Flame Retardants (BFRs) in China Over the Past Half-Century: Stocks, Flows, Fates, and Ecological Risks

Chen,

Ma,

Liu

et al. 2024

Environ. Sci. Technol.

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Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo , Male Zebrafish in Vivo , and GC-1 Cells in Vitro

Yang,

Zhang,

Hua

et al. 2024

Environ Health Perspect

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Background: Legacy brominated flame retardants have been recognized as risky factors leading to declined sperm quality. The widespread utilization of decabromodiphenyl ethane (DBDPE) as a replacement for decabromodiphenyl ether has given rise to considerable concern over its potential risks to reproductive health. Objectives: The objectives were to quickly determine whether DBDPE affects sperm quality upon ex vivo exposure, to reveal the reproductive outcomes and underlying molecular mechanisms using an in vivo zebrafish model exposed to DBDPE, and to validate the potential impact on DNA damage and energy metabolism balance in vitro . Methods: Zebrafish spermatozoa were treated with DBDPE (0.01, 0.1, 1, ) for 3 h, and the spermatozoa motility and fertilization ability with normal eggs were evaluated. Then adult male zebrafish were treated with DBDPE (0.1, 1, 10, and ) for 2 months, and their reproductive performance was examined. Four-dimensional label-free proteome and phosphoproteome were performed in zebrafish testes, and the findings were validated by multiple indicators. Finally, mouse spermatogonial GC-1 cells were treated with DBDPE (0.1, ) for 72 h, and DNA damage was examined, as well as the energy production of glycolysis and oxidative phosphorylation. Results: Ex vivo exposure to DBDPE caused lower motility and fertilization rates of zebrafish spermatozoa. In vivo exposure to DBDPE caused lower sperm motility and abnormal spermatogenesis in male zebrafish testes. Integrated whole-proteome and phosphoproteome analysis revealed DNA damage responses and energy metabolic disorders in zebrafish testes. A dosage window characterized by higher mitochondrial membrane potential (MMP) in combination with unchanged reactive oxygen species and apoptosis rates was observed in both zebrafish testes and GC-1 cells. Discussion: This study suggests that in zebrafish, DBDPE exposure could impair sperm quality and spermatogenesis, and the underlying mechanism could be related to DNA damage and energy metabolic reprogramming in testicular germ cells. https://doi.org/10.1289/EHP14426

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Is it really safe to replace decabromodiphenyl ether (BDE209) with decabromodiphenyl ethane (DBDPE)?: A perspective from hepatotoxicity

Cited by 2 publications

References 46 publications

Brominated Flame Retardants (BFRs) in China Over the Past Half-Century: Stocks, Flows, Fates, and Ecological Risks

Brominated Flame Retardants (BFRs) in China Over the Past Half-Century: Stocks, Flows, Fates, and Ecological Risks

Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo , Male Zebrafish in Vivo , and GC-1 Cells in Vitro

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