IntroductionPeople with lived and living experience (PWLLE) and family members (F) can engage in mental health and substance use health research beyond participant roles, as advisors, co‐researchers, equal partners and research leads. However, implementing meaningful and effective engagement is complex.MethodsThis article profiles five research initiatives involving different lived experience engagement structures, situated in a single tertiary care teaching and research hospital.ResultsThe profiled projects feature various study designs and stages, ranging from initial priority setting to implementation efforts. The levels of engagement range from consultation to PWLLE/F leadership. Across diverse populations, all embody high‐quality engagement and illustrate that PWLLE/F can have an important impact on a wide range of mental health and substance use health research.ConclusionsEngagement can be implemented flexibly within a single research institution to meet a wide range of needs and preferences of researchers and PWLLE/F.Patient and Public ContributionEach of the research initiatives profiled was conducted with substantial lived experience engagement, as described herein. People with lived and living experience from each research initiative are also included in the authorship team and contributed to this manuscript.