2013
DOI: 10.5455/2320-1770.ijrcog20131211
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Is it safe to use intravenous iron sucrose during pregnancy? A randomized controlled trial

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Cited by 11 publications
(25 citation statements)
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“…Of the remaining 33 studies, 14 studies were excluded after full-text reading with justifications (PRISMA flow chart, Annexure 2). Data extraction was done from remaining 19 RCTs [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. One study (Mumtaz et al [37]) was excluded as it did not report minimum required data such as mean, standard deviation and number of observations in each group and the authors could not be contacted.…”
Section: Study Selectionmentioning
confidence: 99%
See 1 more Smart Citation
“…Of the remaining 33 studies, 14 studies were excluded after full-text reading with justifications (PRISMA flow chart, Annexure 2). Data extraction was done from remaining 19 RCTs [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. One study (Mumtaz et al [37]) was excluded as it did not report minimum required data such as mean, standard deviation and number of observations in each group and the authors could not be contacted.…”
Section: Study Selectionmentioning
confidence: 99%
“…Overall, 1633 antenatal women were randomly assigned to IVS (n = 821) or oral iron [ferrous sulphate, ferrous ascorbate or fumarate] group (n = 812) in ten trials [19][20][21][22][23][24][25][26][27][28] and 713 post-partum women were randomized to IVS (n = 351) or OIG (n = 362) in eight studies [29][30][31][32][33][34][35][36]. Summary of characteristics of included studies is presented in Boxes 1 and 2 below.…”
Section: Study Selectionmentioning
confidence: 99%
“…Our meta‐analysis significantly builds on another recent meta‐analysis which led its authors to conclude that the risks of requiring a blood transfusion were similar after intravenous and oral iron therapy (RR, 1.02; 95% CI, 0.99–1.04). Our finding of a significant difference is explained by our identifying three studies not included in the earlier analysis, and by our more appropriate meta‐analytic approach to handling rare events. Other recent reviews have either focused only on haematological parameters or did not meta‐analyse clinical outcomes …”
Section: Discussionmentioning
confidence: 79%
“…Nine RCTs (555 intervention, 535 control participants) reported the risk of maternal blood transfusion. Compared with oral iron, intravenous iron therapy was associated with reduced risk of women requiring blood transfusions (Peto OR, 0.19; 95% CI, 0.05–0.78; low quality evidence).…”
Section: Resultsmentioning
confidence: 99%
“…At all levels, it was shown that iron sucrose increased hemoglobin and iron stores faster than oral iron significantly (p-values of 0.000). 15 Haldar P et al, retrospectively studied 990 pregnant patients who were given 400 mg of intravenous iron sucrose at 2 primary health centers in rural India and found that mean increase of hemoglobin was 1.76 gm% and way higher (1.5times) in severely anemic patients. They recommended that dose of iron sucrose should be calculated as per Ganzoni's formula and dose be given accordingly as was done in this study.…”
Section: Discussionmentioning
confidence: 99%