Is Kidney Function Associated with Age-Related Macular Degeneration?

Xue, Can Can; Sim, Ralene; Chee, Miao Li; Yu, Marco; Wang, Ya Xing; Rim, Tyler Hyungtaek; Hyung, Park Kyu; Woong, Kang Se; Song, Su Jeong; Nangia, Vinay; Panda-Jonas, Songhomitra; Wang, Ning Li; Hao, Jie; Zhang, Qing; Cao, Kai; Sasaki, Mariko; Harada, Sei; Toru, Takebayashi; Ryo, Kawasaki; Raman, Rajiv; Surya, Janani; Khan, Rehana; Bikbov, Mukharram; Wong, Ian Y.; Cheung, Chui Ming Gemmy; Jonas, Jost B.; Cheng, Ching-Yu; Tham, Yih-Chung

doi:10.1016/j.ophtha.2023.12.030

Cited by 1 publication

(1 citation statement)

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“…More recently, a comprehensive study that pooled data from 51,253 participants across 10 different Asian population-based studies found a significant association between CKD (and decreased kidney function) and late AMD. Contrastingly, the same study found no significant association between CKD and early AMD ( Xue et al, 2023 ).…”

Section: Discussionmentioning

confidence: 82%

Association between chronic kidney disease and age-related macular degeneration: a Mendelian randomization study

Hou,

Liu,

Xiao

et al. 2024

Front. Aging Neurosci.

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PurposeObservational studies have reported inconsistent results on the relationship between chronic kidney disease (CKD) and age-related macular degeneration (AMD). The primary objective of this study was to investigate the causal relationships between estimated glomerular filtration rate (eGFR), CKD, its common causes, and AMD among participants of European descent.MethodsGenetic variants associated with eGFR, CKD and its common causes, encompassing diabetic nephropathy (DN), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN) were obtained from previously published genome-wide association studies (GWAS) and FinnGen database. Summary statistics for early AMD, AMD, dry AMD, and wet AMD were acquired from the GWAS and FinnGen database. Inverse-variance-weighted (IVW) method was the main MR analysis. Sensitivity analyses were performed with Cochran’s Q, MR-Egger intercept, and leave-one-out analysis. In addition, RadialMR was utilized to identify and remove outliers.ResultsIVW results showed that CKD, eGFR were not associated with any type of AMD (p > 0.05). DN (OR: 1.042, 95% CI: 1.002–1.083, p = 0.037) and MN (OR: 1.023, 95% CI: 1.007–1.040, p = 0.005) were associated with an increased risk of earl AMD. DN (OR: 1.111, 95% CI: 1.07–1.154, p = 4.87 × 10−8), IgAN (OR: 1.373, 95% CI: 1.097–1.719, p = 0.006), and MN (OR: 1.036, 95% CI: 1.008–1.064, p = 0.012) were associated with an increased risk of AMD. DN (OR: 1.090, 95% CI: 1.042–1.140, p = 1.57 × 10−4) and IgAN (OR: 1.480, 95% CI: 1.178–1.858, p = 7.55 × 10−4) were associated with an increased risk of dry AMD. The risk of wet AMD was associated with DN (OR: 1.107, 95% CI: 1.043–1.174, p = 7.56 × 10−4) and MN (OR: 1.071, 95% CI: 1.040–1.103, p = 5.48 × 10−6).ConclusionThis MR study found no evidence of causal relationship between CKD and AMD. DN, IgAN, and MN may increase risk of AMD. This findings underscore the importance of ocular examinations in patients with DN, MN, and IgAN. More studies are needed to support the findings of our current study.

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Section: Discussionmentioning

confidence: 82%