Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Huang, Yan; Gu, Min; Qi, Weimin; Zhu, Juanfen; Wu, Jian; Wang, Peipei; Wang, Meihua; Luo, Judong

doi:10.3389/fonc.2022.790997

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Furthermore, other genera such as Helicobacter , Lactobacillus , and Fusobacterium were also identified as significant when discriminating HNSC, STAD, and ESCA cancer samples. While Helicobacter has been associated with head and neck cancer 29 , its presence in these tumors is controverse 30 . In the case of gastric cancer, however, there is no doubt on the causal relationship between Helicobacter (pylori) and non-cardia gastric cancer 31 .…”

Section: Resultsmentioning

confidence: 99%

Machine learning-based approaches for cancer prediction using microbiome data

Freitas

Silva

Sousa

et al. 2023

Sci Rep

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Emerging evidence of the relationship between the microbiome composition and the development of numerous diseases, including cancer, has led to an increasing interest in the study of the human microbiome. Technological breakthroughs regarding DNA sequencing methods propelled microbiome studies with a large number of samples, which called for the necessity of more sophisticated data-analytical tools to analyze this complex relationship. The aim of this work was to develop a machine learning-based approach to distinguish the type of cancer based on the analysis of the tissue-specific microbial information, assessing the human microbiome as valuable predictive information for cancer identification. For this purpose, Random Forest algorithms were trained for the classification of five types of cancer—head and neck, esophageal, stomach, colon, and rectum cancers—with samples provided by The Cancer Microbiome Atlas database. One versus all and multi-class classification studies were conducted to evaluate the discriminative capability of the microbial data across increasing levels of cancer site specificity, with results showing a progressive rise in difficulty for accurate sample classification. Random Forest models achieved promising performances when predicting head and neck, stomach, and colon cancer cases, with the latter returning accuracy scores above 90% across the different studies conducted. However, there was also an increased difficulty when discriminating esophageal and rectum cancers, failing to differentiate with adequate results rectum from colon cancer cases, and esophageal from head and neck and stomach cancers. These results point to the fact that anatomically adjacent cancers can be more complex to identify due to microbial similarities. Despite the limitations, microbiome data analysis using machine learning may advance novel strategies to improve cancer detection and prevention, and decrease disease burden.

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Section: Resultsmentioning

confidence: 99%

Machine learning-based approaches for cancer prediction using microbiome data

Freitas

Silva

Sousa

et al. 2023

Sci Rep

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“…Pepsin has been linked to epithelial proliferation and carcinogenesis. Namely, activated pepsin induces inflammation, destruction of the epithelial defense barrier, changes in expression of laryngeal and hypopharyngeal genes and tumorogenesis, and disruption of the function of epithelial cells [33][34][35][36]. Some studies have shown that bile acids and Helicobacter pylori may play a role in the development of laryngeal and hypopharyngeal carcinoma.…”

Section: Complicationsmentioning

confidence: 99%

The Differences between Gastroesophageal and Laryngopharyngeal Reflux

Širić¹,

Rosso²,

Včev³

2023

Gastroesophageal Reflux Disease - A Growing Concern

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Gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) have different pathophysiological mechanisms of occurrence and are characterized by different clinical pictures and symptomatology. In clinical practice, it often happens that LPR remains unrecognized or is defined as atypical gastroesophageal reflux, thus, it is necessary to distinguish between these two clinical entities. Laryngopharyngeal reflux refers to the return of gastric contents from the stomach through the esophagus to the larynx, pharynx, paranasal cavities, middle ear, and lower respiratory tract, and it is part of the wider extraesophageal reflux syndrome (EER). Extraesophageal symptoms are common in GERD, and studies show an increasing prevalence of LPR in patients with GERD, as well as an association of reflux disease with cough and dysphonia symptoms. The aim of the chapter is to describe differences between GER and LPR in order to facilitate the recognition and differentiation of manifest and latent symptoms, diagnosis, and choice of therapeutic approach.

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Is Laryngeal Squamous Cell Carcinoma Related to Helicobacter pylori?

Cited by 2 publications

References 49 publications

Machine learning-based approaches for cancer prediction using microbiome data

Machine learning-based approaches for cancer prediction using microbiome data

The Differences between Gastroesophageal and Laryngopharyngeal Reflux

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