Is leptin a predictive factor in the end of therapy response in chronic hepatitis B?

Abstract

Although the higher leptin value observed in children with ETR was not statistically significant, because of close interactions between leptin, cytokines and lymphocytes, it is thought that leptin should be investigated as a predictive factor of ETR in further studies.

Alterations of leptin during IFN-α therapy in patients with chronic viral hepatitis

“…With regard to CHB patients, our data are consistent to those by Selimoglu et al [40] reporting higher leptin levels in children with CHB. Testa et al [15] have found lower leptin levels compared to controls, but their cohort of CHB patients was rather small and limited to non-cirrhotic.…”

Higher pretherapy and significant decrease during the first 12 months of therapy in serum laminin levels may associate with hepatitis B e antigen seroconversion in chronic hepatitis B patients treated with lamivudine

“…Serum ferritin levels were indicated to be helpful in monitoring and predicting patients' responses to lamivudine therapy [27]. With respect to the stimulating role of leptin in T-cell immunity, determination of the leptin levels in children with chronic HBV infection showed that higher leptin value was observed in children with end of therapy response, but it was not statistically significant [28]. In the present study, we analyzed the changes of serum laminin levels during lamivudine treatment and their associations with treatment response regarding the role of laminin in not only liver fibrosis but also immune regulation.…”

Circulating leptin levels and bone mineral density in children with biliary atresia

“…Recently, role of circulating leptin has been documented in children with immune thrombocytopenic purpura (16,17), celiac disease (18), cystic fibrosis (19) and chronic liver diseases (20)(21)(22)(23). However, the role of leptin and bone metabolism in BA patients has not been fully elucidated.…”