2024
DOI: 10.2147/jir.s441840
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Is Lipopolysaccharide-Induced Lipid Metabolism Disorder in Testis of Rats a Consequence of Plasma Lipid Changes?

Xiaokang Zheng,
Yu Li,
Xuejun Shang
et al.

Abstract: Purpose The systemic infection and inflammation can result in testes injury, whereas the exact mechanism is unknown. The lipid metabolism has a dual impact on controlling metabolism and inflammation, which is a potential pathway. The objective of this study was to determine if changes in plasma lipids during lipopolysaccharide (LPS)-induced systemic inflammation affect the dysregulation of testes lipid metabolism. Materials and Methods LPS (5 mg/kg) was used to induce s… Show more

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“…The metabolic syndrome and associated diseases are characterized by a state of dyslipidemia. Recent studies have proposed that LPS is an relevant regulator of areas in lipid metabolism such as modifying plasma lipid levels ( 76 ) and activating cholesterol metabolism processes ( 77 ), further connecting LPS to dyslipidemia and systemic inflammation. Even though our results point to little or no metabolic dysregulation, a limitation of this study is that we did not explore LPS’ effect on lipid metabolism or markers of sustained inflammation such as gene expression in the liver or relevant biomarkers in plasma.…”
Section: Discussionmentioning
confidence: 99%
“…The metabolic syndrome and associated diseases are characterized by a state of dyslipidemia. Recent studies have proposed that LPS is an relevant regulator of areas in lipid metabolism such as modifying plasma lipid levels ( 76 ) and activating cholesterol metabolism processes ( 77 ), further connecting LPS to dyslipidemia and systemic inflammation. Even though our results point to little or no metabolic dysregulation, a limitation of this study is that we did not explore LPS’ effect on lipid metabolism or markers of sustained inflammation such as gene expression in the liver or relevant biomarkers in plasma.…”
Section: Discussionmentioning
confidence: 99%