Is Liver SUV Stable over Time in 18F-FDG PET Imaging?

Laffon, Éric; Adhoute, Xavier; Clermont, Henri de; Marthan, Roger

doi:10.2967/jnmt.111.090027

Cited by 39 publications

(29 citation statements)

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“…Furthermore, the conspicuity and detectability of the tumor partly also depend on the postinjection time. A later scan could potentially provide a higher contrast-tonoise ratio in malignant lesions (22). In our study, 10 of 12 lesions missed at 40% PET non-TOF were imaged before PET/ CT.…”

Section: Nuclear Medicine: Fdg Dose Reduction In Pet/mr Imaging Sekinmentioning

confidence: 81%

Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

et al. 2018

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Purpose To determine the level of clinically acceptable reduction in injected fluorine 18 ((18)F) fluorodeoxyglucose (FDG) dose in time-of-flight (TOF)-positron emission tomography(PET)/magnetic resonance (MR) imaging by using silicon photomultiplier (SiPM) detectors compared with TOF-PET/computed tomography (CT) using Lu1.8Y0.2SiO5(Ce), or LYSO, detectors in patients with different body mass indexes (BMIs). Materials and Methods Patients were enrolled in this study as part of a larger prospective study with a different purpose than evaluated in this study (NCT02316431). All patients gave written informed consent prior to inclusion into the study. In this study, 74 patients with different malignant diseases underwent sequential whole-body TOF-PET/CT and TOF-PET/MR imaging. PET images with simulated reduction of injected (18)F-FDG doses were generated by unlisting the list-mode data from PET/MR imaging. Two readers rated the image quality of whole-body data sets, as well as the image quality in each body compartment, and evaluated the conspicuity of malignant lesions. Results The image quality with 70% or 60% of the injected dose of (18)F-FDG at PET/MR imaging was comparable to that at PET/CT. With 50% of the injected dose, comparable image quality was maintained among patients with a BMI of less than 25 kg/m(2). PET images without TOF reconstruction showed higher artifact scores and deteriorated sharpness than those with TOF reconstruction. Conclusion Sixty percent of the usually injected (18)F-FDG dose (reduction of up to 40%) in patients with a BMI of more than 25 kg/m(2) results in clinically adequate PET image quality in TOF-PET/MR imaging performed by using SiPM detectors. Additionally, in patients with a BMI of less than 25 kg/m(2), 50% of the injected dose may safely be used. (©) RSNA, 2017 Online supplemental material is available for this article. Purpose:To determine the level of clinically acceptable reduction in injected fluorine 18 ( Materials andMethods:Patients were enrolled in this study as part of a larger prospective study with a different purpose than evaluated in this study (NCT02316431). All patients gave written informed consent prior to inclusion into the study. In this study, 74 patients with different malignant diseases underwent sequential whole-body TOF-PET/CT and TOF-PET/MR imaging. PET images with simulated reduction of injected 18 F-FDG doses were generated by unlisting the list-mode data from PET/MR imaging. Two readers rated the image quality of whole-body data sets, as well as the image quality in each body compartment, and evaluated the conspicuity of malignant lesions. Results:The image quality with 70% or 60% of the injected dose of 18 F-FDG at PET/MR imaging was comparable to that at PET/CT. With 50% of the injected dose, comparable image quality was maintained among patients with a BMI of less than 25 kg/m 2 . PET images without TOF reconstruction showed higher artifact scores and deteriorated sharpness than those with TOF reconstruction. Conclusion:Sixty percent...

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Section: Nuclear Medicine: Fdg Dose Reduction In Pet/mr Imaging Sekinmentioning

confidence: 81%

Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

et al. 2018

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“…For the healthy liver, which reversibly traps 18 F-FDG, the [AUC NIF / λ C pN ( t )] ratio is 164 min, for peak activity at about t = 55 min (Figure two in [19]). Total peak activity is 8.6 kBq/mL, and hence SUV uncorr ( t peak ) = 1.7 g.mL -1 , a value identical to that obtained by Minamimoto et al [17].…”

Section: Resultsmentioning

confidence: 99%

“…Healthy lung irreversibly traps 18 F-FDG and F is not negligible in comparison with the ratio K / (λ + k R ): 63% at peak time [18]. Healthy liver reversibly traps 18 F-FDG and F is not negligible in comparison with the ratio K / (λ + k R ): 26% at peak time [19]. Furthermore, it should be noted that neglecting reversibility of the 18 F-FDG uptake in healthy brain and liver leads to an overestimation of integrated activity that can be approached by comparing the [AUC NIF / λ C pN ( t peak )] ratio obtained at t = 62 and 55 min to that obtained at t = 79 min (=269/187 and 269/164), which differs by 44% and 64%, respectively: the greater the release rate constant, the greater the overestimation.…”

Section: Discussionmentioning

confidence: 99%

Calculating an estimate of tissue integrated activity in 18F-FDG PET imaging using one SUV value

et al. 2013

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BackgroundA kinetic model analysis was recently proposed to estimate the 18F-fluorodeoxyglucose (18F-FDG) integrated activity in an arbitrary tissue that uses tracer uptake and release rate constants. The aim of the current theoretical paper was to estimate 18F-FDG integrated activity using one standardized uptake value (SUV).MethodsA further kinetic model analysis allowed us to derive an analytical solution for integrated activity determination, involving both irreversible and reversible trapping. It only uses SUV, which is uncorrected for 18F physical decay (SUVuncorr, in g.mL−1) and is assessed about its peak value. Measurement uncertainty of the estimate was also assessed.ResultsIn a tissue (volume V, in mL) that irreversibly traps 18F-FDG, the total number of disintegrations can be estimated as: ÃC = 162 * 105 * SUVuncorr * V * ID / W (ID, injected dose, in MBq; W, patient’s weight, in kg), where SUVuncorr is a mean over V and is assessed between 55 and 110 min after tracer injection. The relative uncertainty ranges between 18% and 30% (the higher the uptake, the lower the uncertainty). Comparison with the previous Zanotti-Fregonara’s model applied to foetus showed less than 16% difference. Furthermore, calculated integrated activity estimates were found in good agreement with Mejia’s results for healthy brain, lung and liver that show various degrees of tracer trapping reversibility and various fractions of free tracer in blood and interstitial volume.ConclusionEstimation of integrated activity in an arbitrary tissue using one SUV value is possible, with measurement uncertainty related to required assumptions. A formula allows quick estimation that does not underestimate integrated activity so that it could be helpful in circumstances such as accidental exposure, or for epidemiologic purposes such as in patients having undergone several examinations.

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“…However, a prospective study by Laffon et al performed PET acquisition at two time points on the same day and reported that the decay-corrected SUV of the liver remains nearly constant if the time delay between tracer injection and PET acquisition is in the range of 50–110 min. [17] This suggests that in clinical practice, liver SUV can be used for comparison with SUV of suspected malignant lesions, if comparison is made within this timeframe.…”

Section: Discussionmentioning

confidence: 99%

Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases

et al. 2016

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BackgroundThe presence of cervical lymph node metastasis is an important prognostic factor for patients with head and neck squamous cell carcinomas (HNSCC). Accurate assessment of lymph node metastasis in these patients is essential for appropriate prognostic and management purposes. Here, we evaluated the effectiveness of the maximum standardized uptake value (SUVmax) on positron emission tomography (PET) in assessing lymph node metastasis in HNSCC prior to surgery.MethodsA retrospective review of 74 patients with HNSCC who underwent PET/CT prior to neck dissection were examined. Pre-operative PET/CT scans were reviewed by two experienced nuclear medicine physicians and SUVmax of the largest node in each nodal basin documented. These were compared with the histology results of the neck dissection.ResultsA total of 359 nodal basins including 86 basins with metastatic nodes were evaluated. A nodal SUVmax ≥3.16 yielded a sensitivity of 74.4 % and specificity of 84.9 % in detecting metastatic nodes. The nodal SUVmax/Liver SUVmax ratio was found on receiver operating characteristic (ROC) to be effective in detecting metastatic nodes with an area under ROC curve of 0.90. A nodal SUVmax/Liver SUVmax ratio ≥0.90 yielded a sensitivity of 74.1 % and specificity of 93.4 %. By comparison, visual inspection yielded sensitivities of 66.3 and 61.6 % in observers 1 and 2 respectively. The corresponding specificities were 77.7 and 86.5 %.ConclusionsNodal SUVmax and nodal SUVmax/liver SUVmax are both useful in the pre-operative detection of metastatic nodes with the latter being superior to visual inspection. The ratio is likely to be more useful as it corrects for inter-scanner variability.

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Is Liver SUV Stable over Time in 18F-FDG PET Imaging?

Cited by 39 publications

References 14 publications

Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

Calculating an estimate of tissue integrated activity in 18F-FDG PET imaging using one SUV value

Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases

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Is Liver SUV Stable over Time in 18F-FDG PET Imaging?

Cited by 39 publications

References 14 publications

Reduction of 18F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

Reduction of 18F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

Calculating an estimate of tissue integrated activity in 18F-FDG PET imaging using one SUV value

Utility of SUVmax on 18 F-FDG PET in detecting cervical nodal metastases

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Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors

Reduction of ¹⁸F-FDG Dose in Clinical PET/MR Imaging by Using Silicon Photomultiplier Detectors