Is low-level metal exposure related to testicular cancer?

Lovaković, Blanka Tariba; Semren, Tanja Živković; Safner, Toni; Gamulin, Marija; Soče, Majana; Pizent, Alica

doi:10.1080/26896583.2021.1874234

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…Similar results were obtained in other studies. Significantly higher erythrocyte SOD was measured in prostate [ 97 ] and testicular [ 100 ] cancer patients compared to the control. Additionally, the depletion of GSH in testicular cancer patients was observed [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

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Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

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Section: Discussionmentioning

confidence: 99%

“…Significantly higher erythrocyte SOD was measured in prostate [ 97 ] and testicular [ 100 ] cancer patients compared to the control. Additionally, the depletion of GSH in testicular cancer patients was observed [ 100 ]. In the current study, decreased SH levels were associated with increased blood Cd and Hg levels.…”

Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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“…The ubiquitous presence of trace elements may present an environmental and health concern, particularly in sensitive microenvironments like childcare and educational facilities. Although some of these elements are essential for human health and well‐being at specific permissible levels (Se, Zn, Mn), others like As, Cd, Cr, and Pb can have negative impact on human health even at low exposure levels 1–3 . Dust particles can adsorb organic and inorganic contaminants, including trace metals 4,5 acting as a repository and also a transport medium.…”

Section: Introductionmentioning

confidence: 99%

“…As previously mentioned, many of these elements are toxic at high concentrations and act as a potential initiators or promoters in diseases. Some of them (e.g., Pb, Ni, Cd, and As) may induce adverse health effects even at low doses, particularly in the conditions of long‐term exposure that is characteristic for environmental exposure 3,41 . We estimated young children's (2–6 years of age) exposure to elements considering major intake pathways (ingestion, inhalation, and dermal absorption) and two scenarios (central and worst‐case scenario) and assessed the health risk from overall exposure to trace elements taking into consideration element concentrations measured in dust from three different microenvironments where children spend most of their time—home, car, and kindergarten.…”

Section: Introductionmentioning

confidence: 99%

“…Although some of these elements are essential for human health and well-being at specific permissible levels (Se, Zn, Mn), others like As, Cd, Cr, and Pb can have negative impact on human health even at low exposure levels. [1][2][3] Dust particles can adsorb organic and inorganic contaminants, including trace metals 4,5 acting as a repository and also a transport medium. Indoor dust is a composite of both interior (i.e., construction, insulating, and decorative materials, home textiles, furniture, and appliances, cigarette smoking) and exterior (i.e., traffic emission, waste burning, and urbanization) sources of pollution.…”

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confidence: 99%

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Trace elements in indoor dust—Children's health risk considering overall daily exposure

et al. 2022

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Urbanization and industrialization keep contributing to increased pollution in the cities, including the contamination of indoor and outdoor environment with potentially toxic elements. The ubiquitous presence of trace elements may present an environmental and health concern, particularly in sensitive microenvironments like childcare and educational facilities. Although some of these elements are essential for human health and well-being at specific permissible levels (Se, Zn, Mn), others like As, Cd, Cr, and Pb can have negative impact on human health even at low exposure levels. [1][2][3] Dust particles can adsorb organic and inorganic contaminants, including trace metals 4,5 acting as a repository and also a transport medium. Indoor dust is a composite of both interior (i.e., construction, insulating, and decorative materials, home textiles, furniture, and appliances, cigarette smoking) and exterior (i.e., traffic emission, waste burning, and urbanization) sources of pollution. 6,7 Settled dust as a source of exposure to toxic elements has been extensively studied 5,8,9 since the modern way of life, for both adults and children, mostly implies spending the majority of our time indoors.Young children spend most of their time at home and in kindergartens, with a small, but potentially significant fraction of the daily time spent in the car. Faria et al. 10 recently confirmed that homes and schools are microenvironments that contribute most to the children's daily exposure and inhaled dose of particulate matter (PM), including trace elements. A comprehensive analysis of the exposure in the three microenvironments, namely home, work, and transport, obtained recently by Singh et al. 11 for the population of London,

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