Is low total cholesterol levels associated with suicide attempt in depressive patients?

Messaoud, A.; Mensi, R.; Mrad, Ali Ben; Mhalla, Ahmed; Azizi, Islem; Amemou, B.; Trabelsi, Imen; Grissa, Mohamed Habib; Salem, Nidhal Haj; Chadly, Ali; Douki, Wahiba; Najjar, Mohamed Fadhel; Gaha, L.

doi:10.1186/s12991-017-0144-4

Cited by 59 publications

(68 citation statements)

References 39 publications

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“…Moreover, considering that both nutritional status and stress may affect blood lipid levels, the one time-point measurement of blood lipid levels at admission may not reflect the patient’s baseline level ( 24 ). Sixth, there were more female patients in this study, which may be a potential confounder, because the MDD and suicidality are more common in women than men ( 17 ). Finally, past suicide attempts may be due to depression or even a depressive episode.…”

Section: Discussionmentioning

confidence: 95%

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Zhou

Wang

et al. 2020

Front. Psychiatry

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Several studies have reported a link between lipid disorders and suicidality. However, few studies have investigated the relationship between suicidal behavior and blood lipid profiles in patients with first-episode and drug-naive (FEDN) major depressive disorder (MDD). The main purpose of this study was to examine the relationship between plasma lipid profiles and suicide attempts in a large sample of FEDN MDD patients in the Chinese Han population, which has not been reported. A total of 1,718 MDD outpatients were recruited. Their clinical and demographic data as well as plasma lipid parameters were collected. We obtained suicide attempt data through interviews with patients and their family members. We rated the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) for all patients. The suicide attempt rate of MDD patients was 20.14%, of which 13.68% in the last month and 6.46% in the past. Further, compared with non-attempters, suicide attempters had significantly higher total levels of cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c), higher HAMA and HAMD scores, but significantly lower high-density lipoprotein cholesterol (HDL-c) levels. Logistic regression analysis showed that suicide attempts were correlated with higher TC, lower HDL-c, and higher HAMA and HAMD scores with the adjusted odds ratio (OR) of 1.35, 0.52,1.28, and 1.08, respectively (all p < 0.05). Our findings suggest that FEDN patients with MDD have a high rate of attempted suicide. In the early stage of MDD patients, certain blood lipid parameters and more severe symptoms of anxiety and depression are correlated with suicide attempts. However, due to the cross-sectional design of this study, it is impossible to draw a causal relationship between lipid profiles and suicide attempts. Moreover, an inverse correlation can also be considered, that is, high cholesterol may be the consequence of suicide attempts and depression.

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Section: Discussionmentioning

confidence: 95%

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Zhou

Wang

et al. 2020

Front. Psychiatry

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“…Shrivastava et al ( 69 ) in a naturalistic cross-sectional cohort study of 60 patients with early psychosis, found that low levels of cholesterol were present only in the group of patients with severe suicidality. Similarly, Messaoud et al ( 70 ) found a positive association between low plasma cholesterol level and suicidal behavior in patients with major depressive disorder.…”

Section: Lifestyle Behavior and Suicide In Young Adults And Adultsmentioning

confidence: 85%

Lifestyle Interventions and Prevention of Suicide

et al. 2018

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Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle behaviors are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. The current article provides a comprehensive review of the literature on lifestyle interventions, mental health, and suicide risk in the general population and in patients with psychiatric disorders. For this purpose, we investigated lifestyle behaviors and lifestyle interventions in three different age groups: adolescents, young adults, and the elderly. Several lifestyle behaviors including cigarette smoking, alcohol use, and sedentary lifestyle are associated with suicide risk in all age groups. In adolescents, growing attention has emerged on the association between suicide risk and internet addiction, cyberbullying and scholastic and family difficulties. In adults, psychiatric symptoms, substance and alcohol abuse, weight, and occupational difficulties seems to have a significant role in suicide risk. Finally, in the elderly, the presence of an organic disease and poor social support are associated with an increased risk of suicide attempt. Several factors may explain the association between lifestyle behaviors and suicide. First, many studies have reported that some lifestyle behaviors and its consequences (sedentary lifestyle, cigarette smoking underweight, obesity) are associated with cardiometabolic risk factors and with poor mental health. Second, several lifestyle behaviors may encourage social isolation, limiting the development of social networks, and remove individuals from social interactions; increasing their risk of mental health problems and suicide.

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“…Previously, some studies have also shown an association between low cholesterol and increased risk of death due to injuries or suicide [ 2 , 9 , 26 – 29 ], but not in other reports [ 1 , 30 – 33 ], even elevated cholesterol levels have been associated with suicide mortality in other studies [ 15 , 33 ].…”

Section: Discussionmentioning

confidence: 97%

“…Although roughly 60% of all suicides occur in the context of depressive disorders [ 7 , 8 ] it is still challenging for clinicians to predict suicide risk in patients with depression. For this reason, increased attention has been paid to potential biomarkers for suicide in patients with major depressive disorder (MDD) and suicidal behavior [ 1 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population

et al. 2018

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BackgroundCholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT1A serotonin receptor. For this, low cholesterol level has been reported to be associated with depression and suicidality. However there have been inconsistent reports about this finding and the exact relationship between these factors remains controversial. Therefore, we investigated the link between serum cholesterol and its fractions with depression disorder and suicide attempt in 467 adult subjects in Mexican mestizo population.MethodsPlasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were determined in 261 MDD patients meeting the DSM-5 criteria for major depressive disorder (MDD), 59 of whom had undergone an episode of suicide attempt, and 206 healthy controls.ResultsA significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride serum levels was observed in the groups of MDD patients and suicide attempt compared to those without suicidal behavior (p < 0.05). After adjusting for covariates, lower cholesterol levels were significantly associated with MDD (OR 4.229 CI 95% 2.555 – 7.000, p<.001) and suicide attempt (OR 5.540 CI 95% 2.825 – 10.866, p<.001)ConclusionsThese results support the hypothesis that lower levels of cholesterol are associated with mood disorders like MDD and suicidal behavior. More mechanistic studies are needed to further explain this association.

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Is low total cholesterol levels associated with suicide attempt in depressive patients?

Cited by 59 publications

References 39 publications

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Association of Lipid Profile and Suicide Attempts in a Large Sample of First Episode Drug-Naive Patients With Major Depressive Disorder

Lifestyle Interventions and Prevention of Suicide

Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population

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