Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study

Dennison, Elaine; Dhanwal, Dinesh; Shaheen, Salma; Azagra, R; Reading, Isabel; Jameson, Karen; Sayer, Avan A.; Cooper, Cyrus

doi:10.1007/s11657-012-0115-y

Cited by 19 publications

(11 citation statements)

References 21 publications

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“… 7 , 10 , 31 , 49 , 50 Correlation between BMD and FEV 1 has also been demonstrated in the general population in some, but not all, reports. 93 – 95 In COPD patients, the correlation of pulmonary function and/or GOLD stages with BMD seems to be, in part, mediated by BMI, and the correlation of GOLD stages with fracture prevalence was not always apparent. 7 , 10 , 28 Although the exact reason is unclear, some mechanisms causing BMD-independent fracture risk, ie, bone quality, may be operating in COPD (as discussed earlier).…”

Section: Risk Factors Of Osteoporosis In Copdmentioning

confidence: 99%

COPD and osteoporosis: links, risks, and treatment challenges

Inoue¹,

Watanabe²,

Okazaki³

2016

COPD

129

105

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Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease associated with various systemic comorbidities including osteoporosis. Osteoporosis and its related fractures are common and have significant impacts on quality of life and even respiratory function in patients with COPD. COPD-associated osteoporosis is however extremely undertreated. Recent studies have suggested that both decreased bone mineral density (BMD) and impaired bone quality contribute to bone fragility, causing fractures in COPD patients. Various clinical risk factors of osteoporosis in COPD patients, including older age, emaciation, physical inactivity, and vitamin D deficiency, have also been described. It is critically important for pulmonologists to be aware of the high prevalence of osteoporosis in COPD patients and evaluate them for such fracture risks. Routine screening for osteoporosis will enable physicians to diagnose COPD patients with comorbid osteoporosis at an early stage and give them appropriate treatment to prevent fracture, which may lead to improved quality of life as well as better long-term prognosis.

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Section: Risk Factors Of Osteoporosis In Copdmentioning

confidence: 99%

COPD and osteoporosis: links, risks, and treatment challenges

Inoue¹,

Watanabe²,

Okazaki³

2016

COPD

129

105

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“…Decreased forced expiratory volume in one second (FEV1.0) and/or advanced Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages have been demonstrated to be correlated with lower BMD. [ 6 8 10 27 37 ] Some [ 81 82 ] but not all [ 83 ] have reported correlation between BMD and FEV1.0 in the general population. In COPD patients the correlation of pulmonary function and/or GOLD stages with BMD seems to be in part mediated by BMI, whereas the correlation between BMD and with fracture prevalence was not always apparent.…”

Section: Disease-specific Risk Factors For Osteoporosis In Copdmentioning

confidence: 99%

Osteoporosis Associated with Chronic Obstructive Pulmonary Disease

2016

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Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis. COPD-associated osteoporosis is however extremely under-recognized, hence undertreated. Recent studies have suggested that both decreased bone mineral density (BMD) and impaired bone quality compromise bone strength causing fractures in COPD. In COPD patients, various general clinical risk factors for osteoporosis are present including smoking, older age, low body weight, and physical inactivity. In addition, disease-related risk factors such as decreased pulmonary function, inflammation, glucocorticoid use and vitamin D deficiency/insufficiency have been linked to the development of osteoporosis in COPD. Increased awareness of osteoporosis in COPD, especially that of high prevalence of vertebral fractures is called upon among general physicians as well as pulmonologists. Routine screening for osteoporosis and risk assessment of fractures will enable physicians to diagnose COPD patients with comorbid osteoporosis at an early stage. Timely prevention of developing osteoporosis together with appropriate treatment of established osteoporosis may improve QOL and ADL of the COPD patients, preserve their lung function and eventually result in better prognosis in these patients.

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“…So far, the efficient method to estimate lung function of college student is by determining VC, which offer information essential for the characterization of the pathophysiological state resulting from abnormalities in the pulmonary-ventilatory processes [ 19 ]. Research findings have pointed out that there are many factors that can affect VC, such as weight [ 20 ], bone mineral density [ 21 ], chronic obstructive pulmonary disease [ 22 ], BMI [ 17 ], hypertension [ 23 ] and diabetes [ 24 ]. However, few studies have been done on body mass index and vital capacity, especially in college students.…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index (BMI) and vital capacity of college students of Zhuang nationality in China: a cross-section study

Liu

Lü

et al. 2017

Oncotarget

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ObjectiveOur study is to evaluate the association between body mass index (BMI) and vital capacity of college students of Zhuang Nationality in China.Methods463 college students of Zhuang Nationality from Guangxi Medical University were selected. Basic information, body composition and vital capacity of college students were measured. According to the level of BMI, college students were divided into four groups (BMI<18.5, 18.5≤BMI<23.9, 23.9≤BMI<27.9 and BMI≥27.9). Multivariate logistic regression analysis was performed to assess the association between BMI and vital capacity.ResultsIn male college students, there was no significant difference in vital capacity between the four groups (3029.54±869.25, 3347.06±784.54, 3540.00±805.35 and 3966.50±350.2, P=0.0727, respectively). Multivariate regression analysis showed that after adjusting for confounding factors, no significant association was observed between BMI and vital capacity (OR=115.02, 95% CI: -555.58∼785.63; OR=-166.58, 95% CI: -1684.56∼1351.41; OR=-484.01, 95% CI:-3504.53, 2536.51, respectively. BMI<18.5 group served as reference group). In female college students, there was also no significant difference in vital capacity between the four groups (2455.15±574.4, 2555.06±637.03, 2750.33±1224.05 and 2473.00±159.06, P=0.4011, respectively). Multivariate regression analysis showed that after adjusting for confounding factors, no significant association was observed between BMI and vital capacity (OR=-88.88, 95% CI: -333.59∼155.84; OR=20.00, 95% CI: -694.39∼734.39; OR=2.86, 95% CI: -1830.58, 1836.3, respectively. BMI<18.5 group served as reference group).ConclusionThere was no evidence that BMI is associated with vital capacity in college students of Zhuang Nationality.

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Is lung function associated with bone mineral density? Results from the Hertfordshire Cohort Study

Cited by 19 publications

References 21 publications

COPD and osteoporosis: links, risks, and treatment challenges

COPD and osteoporosis: links, risks, and treatment challenges

Osteoporosis Associated with Chronic Obstructive Pulmonary Disease

Association between body mass index (BMI) and vital capacity of college students of Zhuang nationality in China: a cross-section study

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