Is medicinal ketamine associated with urinary dysfunction issues? Assessment of both the European Medicines Agency (<scp>EMA</scp>) and the <scp>UK</scp> Yellow Card Scheme pharmacovigilance database‐related reports

Schifano, Nicolò; Chiappini, Stefania; Castiglione, Fabio; Salonia, Andrea; Schifano, Fabrizio

doi:10.1111/luts.12355

Cited by 10 publications

(14 citation statements)

References 30 publications

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“…According to the European Medicines Agency (EMA) and the UK Yellow Card Scheme pharmacovigilance database about 23% and 17% of ketamine-related adverse drug reactions (ADR) respectively referred to renal/urinary disorders. Interestingly, such issues being more common among women than men [94]. In general, urological problems occur within 1 month-1 year time frame following the start of ketamine use, but recent pharmacovigilance data revealed that even an acute ketamine administration may be associated with urological risks, as in some cases the risk was noticed within 48 hours of treatment [94].…”

Section: Ketamine-induced Uropathy: "The Ketamine Bladder"mentioning

confidence: 99%

“…Interestingly, such issues being more common among women than men [94]. In general, urological problems occur within 1 month-1 year time frame following the start of ketamine use, but recent pharmacovigilance data revealed that even an acute ketamine administration may be associated with urological risks, as in some cases the risk was noticed within 48 hours of treatment [94].…”

Section: Ketamine-induced Uropathy: "The Ketamine Bladder"mentioning

confidence: 99%

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An Update of Ketamine Illicit Use

Kleczkowska¹,

Zaremba²

2022

Ketamine Revisited - New Insights Into NMDA Inhibitors

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Ketamine is a derivative of phencyclidine with unique anesthetic, analgesic, as well as antidepressant pharmacological properties. Despite its clinical use, ketamine is classified on the list with new psychoactive substances having psychedelic properties. The abuse trend of ketamine increasing globally, and it became a common club drug over the past few decades. Of note, recreational use of ketamine may pose a threat to public health, leading to numerous physical, as well as psychiatric negative effects. In addition, simultaneously or sequentially ketamine use with other drugs, resulting in serious health consequences. Currently, there are no specific treatment options for managing compulsive drug-seeking behavior in patients with ketamine use disorder, while the pharmacotherapy of side effects is limited and mostly symptomatic. In this chapter, we discuss ketamine abuse history. Further, we proposed the mechanisms of neural disinhibition underlying addiction development in ketamine-dependent patients. We have also included details of possible negative consequences focusing on long-term and recreational ketamine use for both, central and peripheral systems. Finally, we provide an overview of ketamine concomitant use and corresponding adverse interactions.

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Section: Ketamine-induced Uropathy: "The Ketamine Bladder"mentioning

confidence: 99%

Section: Ketamine-induced Uropathy: "The Ketamine Bladder"mentioning

confidence: 99%

An Update of Ketamine Illicit Use

Kleczkowska¹,

Zaremba²

2022

Ketamine Revisited - New Insights Into NMDA Inhibitors

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“…Reported bladder problems include: urinary cystitis caused by repeated dosing or long-term use; incontinence; painful bladder; bladder shrinkage; damage to the kidney and urethral obstruction, which can lead to the removal of the bladder; dilated common bile ducts and epigastric pain ( Bhattacharya, 2011 ; Colebunders and Van Erps, 2008 ; Ng et al., 2010 ; Wood et al, 2012a ). Some ketamine-related urinary dysfunction can occur after relatively short periods of use ( Schifano et al, 2020 ). Longer exposure to ketamine and depression appear to increase the risk of lower urinary tract symptoms ( Chen et al., 2018 ).…”

Section: ‘State-of-the-art’ Reviewmentioning

confidence: 99%

Recreational ketamine-related deaths notified to the National Programme on Substance Abuse Deaths, England, 1997–2019

et al. 2021

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Background: Ketamine is a phencyclidine derivative with dissociative anaesthetic properties. Increasing numbers of individuals in England take ketamine recreationally. Information on deaths arising from such use in England is presented. Methods: Cases were extracted on 31 January 2020 from the National Programme on Substance Abuse Deaths database, based on text searches of the cause of death, coroner’s verdict and positive toxicology results for the terms ‘ketamine’ or ‘norketamine’. Findings: During 1997–2005, there were <5 deaths p.a. in which ketamine was implicated. Numbers increased until 2009 (21), plateauing until 2016; thereafter, deaths have risen to about 30 p.a. Decedents’ characteristics ( N = 283): male 84.1%, mean age 31.2 (SD 10.0) years, employed 56.5%, drug use history 79.6% and living with others 60.3%. Ketamine was detected with other substances in most cases. Main (74.6%) underlying cause of death was accidental poisoning. Ketamine may have impaired judgement in other cases. Conclusions: Although controlled, recreational ketamine use and related fatalities continue to increase. Consumers need to be more aware of the potentially fatal risks they face.

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“…These molecules produce similar effects to LSD but possess a higher potency [10]. All these serotonergic agents may induce a serotonin syndrome, hepatic toxicity, and modifications of endocrinological function [22] (Table 1).…”

Section: Novel Stimulants: Synthetic Cathinones and Psychedelic Phene...mentioning

confidence: 99%

“…Subjective effects (e.g., 'K-hole') include dissociation from both the setting and the body, auditory/visual hallucinations, unusual thought content, euphoria and visual distortions [10]. Its related risks may include trauma, drowning, death from hypothermia, traffic accidents [5], and severe urinary dysfunction issues [22] (Table 1).…”

Section: Phencyclidine (Pcp)-like Substancesmentioning

confidence: 99%