Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions

Aykan, Ahmet Çağrı; Gül, İlker; Kalaycıoğlu, Ezgi; Gökdeniz, Tayyar; Hatem, Engin; Menteşe, Ümit; Yıldız, Banu Şahi̇n; Yıldız, Mustafa

doi:10.5603/cj.a2013.0126

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…Aykan AC et al studied 'Is metabolic syndrome related with CAD severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions' and found MS is associated with the presence and complexity of CAD. 5 Rana et al also reported more CAD in DM versus non-DM individuals [SVD (19 vs. 14%), DVD (9 vs. 7%), and TVD (9 vs. 5%) (P < 0.0001 for all)]. 6 Others have also observed similar findings.…”

Section: Resultssupporting

confidence: 59%

Coronary angiographic abnormalities in patients of diabetes mellitus and metabolic syndrome

Saha¹,

Tripathi²,

Kuila³

2017

Int J Res Med Sci

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Background: Diabetes mellitus and Metabolic syndrome, both are established risk factors for CAD. In our study, we tried to compare the effects of these two diseases individually as well as their combined effect.Methods: we performed an Observational, cross-sectional, hospital-based, single center study on 240 patients presenting at our hospital with chest pain. we assessed the severity of CAD with Syntax score and divided the study population into three groups with SS of <=22, 23-32 and >=33.Results: statistically significant difference was found in each of the first three groups of combined MS plus DM, only MS without DM, only DM without MS when compared with the fourth group of nondiabetics nonmetabolic syndrome patients. Strongest difference was found between patients with combined diabetes and metabolic syndrome with those who had none of these (<0.001). Thus, complexity of CAD is much severe in patients who have diabetes and/or metabolic syndrome.Conclusions: Patients having diabetes mellitus and/or metabolic syndrome are found to have more severe form of coronary artery disease than those who don’t have either of these. However, presence of both diabetes and metabolic syndrome has not been found to impose any significant additional risk than their isolated presence.

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Section: Resultssupporting

confidence: 59%

Coronary angiographic abnormalities in patients of diabetes mellitus and metabolic syndrome

Saha¹,

Tripathi²,

Kuila³

2017

Int J Res Med Sci

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“…Additionally, the participants were all Southeast Chinese males, who have unique dietary habits and heredity features. Previous studies have indicated that varying definitions of MetS and different races might influence clinical outcomes 24 – 26 and thus partially explained the differences between the present study and others. Furthermore, the synergistic effect of MetS was determined using all of its components, which not only have complicated mechanisms but also are far from clear.…”

Section: Discussioncontrasting

confidence: 67%

Interaction of smoking and metabolic syndrome in increasing the recurrence risk of colorectal cancer in a Chinese male cohort: a retrospective study

Chen¹,

Ji²,

Xu³

et al. 2018

Sci Rep

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Whether smoking and metabolic syndrome (MetS) can affect colorectal carcinoma (CRC) prognosis remains debatable. Therefore, the present study aimed to examine the individual and combined effects of smoking and MetS on the prognosis of patients with localized CRC, including stage I to III disease. The relationship among smoking status, MetS, and CRC was assessed in 838 Chinese male patients. Cox proportional hazards regression analysis was used to evaluate CRC prognosis adjusted for clinicopathological variables. Relative excess risk of interaction (RERI), attributable proportion (AP), and synergy index (SI) were used to evaluate additive interactions between smoking and MetS. The presence of MetS was an independent risk factor for low rates of recurrence-free survival (RFS) but not for overall survival (OS). However, smoking was independently associated with both poor RFS and OS. Furthermore, the recurrence risk for current smokers with MetS was 1.62 times as high as the sum of risks in patients exposed to each risk factor alone. In conclusion, current smoking habit is a risk factor for both recurrence and cancer-specific mortality in CRC patients, while MetS is an independent predictor for CRC recurrence. Furthermore, these two factors have an additive effect on the recurrence risk of CRC.

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“…First, we chose the Chinese criteria for MetS in this study. Using different criteria would likely generate slightly different incident rates of MetS that may influence the results of clinical outcomes [ 8 , 38 ]. Secondly, short follow-up time (5 years) and a relatively small sample size of MetS patients ( n = 221) may constitute other limitations of our study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome contributes to an increased recurrence risk of non-metastatic colorectal cancer

et al. 2015

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ObjectivesEpidemiological data suggests a close link between metabolic syndrome (MetS) and non-metastatic colorectal cancer (NMCRC). However, the relationship between MetS and the outcome of NMCRC is less well understood. We aim to evaluate the impact of MetS on the prognosis in NMCRC patients.MethodsWe performed a large cohort study of 1069 NMCRC patients. The Kaplan-Meier method was used to calculate the cumulative survival rate. Cox proportional hazard regression models were used to analyze the prognosis associated with MetS adjusting for clinicopathologic variables.ResultsMetS was identified in 20.7% of NMCRC patients. Patients with MetS were more likely to be older, higher levels of blood glucose, triglycerides, high density lipoprotein, and uric acid than patients without MS (P < 0.05 for all). During a mean period of 59.6 months follow-up, patients with MetS had a statistically significantly lower rate of disease-free survival (DFS) than the patients without MetS (P = 0.014), especially local recurrence (P = 0.040). However, there was no difference in overall survival (P = 0.116). Multivariate analysis showed that the presence of MetS was an independent risk factor for DFS (HR = 0.733, 95%CI 0.545–0.987, P = 0.041), but not for OS (P = 0.118).ConclusionsMetS is associated with an increased recurrence risk of NMCRC.

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Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions

Cited by 12 publications

References 24 publications

Coronary angiographic abnormalities in patients of diabetes mellitus and metabolic syndrome

Coronary angiographic abnormalities in patients of diabetes mellitus and metabolic syndrome

Interaction of smoking and metabolic syndrome in increasing the recurrence risk of colorectal cancer in a Chinese male cohort: a retrospective study

Metabolic syndrome contributes to an increased recurrence risk of non-metastatic colorectal cancer

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